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PubMed code 11020273

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092365
PNG
((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Show SMILES O=S(=O)(N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N)c1cccs1
Show InChI InChI=1S/C25H23N5O2S2/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22/h1-11,14,18,23H,12,15-17H2,(H,27,28)/t23-/m1/s1
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n/an/a 1.35n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092366
PNG
(3-Benzyl-4-(2-dimethylamino-ethanesulfonyl)-1-(3H-...)
Show SMILES CN(C)CCS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C25H30N6O2S/c1-29(2)10-11-34(32,33)31-16-22-12-21(14-26)8-9-25(22)30(17-23-15-27-19-28-23)18-24(31)13-20-6-4-3-5-7-20/h3-9,12,15,19,24H,10-11,13,16-18H2,1-2H3,(H,27,28)/t24-/m1/s1
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n/an/a 1.53n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092377
PNG
(4-Benzenesulfonyl-3-benzyl-1-(3H-imidazol-4-ylmeth...)
Show SMILES O=S(=O)(N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N)c1ccccc1
Show InChI InChI=1S/C27H25N5O2S/c28-15-22-11-12-27-23(13-22)17-32(35(33,34)26-9-5-2-6-10-26)25(14-21-7-3-1-4-8-21)19-31(27)18-24-16-29-20-30-24/h1-13,16,20,25H,14,17-19H2,(H,29,30)/t25-/m1/s1
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n/an/a 1.77n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092363
PNG
(3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(propane-1-s...)
Show SMILES CCCS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C24H27N5O2S/c1-2-10-32(30,31)29-15-21-11-20(13-25)8-9-24(21)28(16-22-14-26-18-27-22)17-23(29)12-19-6-4-3-5-7-19/h3-9,11,14,18,23H,2,10,12,15-17H2,1H3,(H,26,27)/t23-/m1/s1
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n/an/a 1.77n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092372
PNG
(3-Benzyl-7-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,...)
Show SMILES CN(C)S(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C23H26N6O2S/c1-27(2)32(30,31)29-14-20-10-19(12-24)8-9-23(20)28(15-21-13-25-17-26-21)16-22(29)11-18-6-4-3-5-7-18/h3-10,13,17,22H,11,14-16H2,1-2H3,(H,25,26)/t22-/m1/s1
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n/an/a 2.85n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092357
PNG
(3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfo...)
Show SMILES CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C22H23N5O2S/c1-30(28,29)27-13-19-9-18(11-23)7-8-22(19)26(14-20-12-24-16-25-20)15-21(27)10-17-5-3-2-4-6-17/h2-9,12,16,21H,10,13-15H2,1H3,(H,24,25)/t21-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092375
PNG
(1-(3H-Imidazol-4-ylmethyl)-4-methanesulfonyl-7-phe...)
Show SMILES CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1cccnc1)-c1ccccc1
Show InChI InChI=1S/C26H27N5O2S/c1-34(32,33)31-16-23-13-22(21-7-3-2-4-8-21)9-10-26(23)30(17-24-15-28-19-29-24)18-25(31)12-20-6-5-11-27-14-20/h2-11,13-15,19,25H,12,16-18H2,1H3,(H,28,29)/t25-/m1/s1
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n/an/a 5.95n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092371
PNG
(3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfo...)
Show SMILES CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1)-c1cccnc1
Show InChI InChI=1S/C26H27N5O2S/c1-34(32,33)31-16-23-13-21(22-8-5-11-27-14-22)9-10-26(23)30(17-24-15-28-19-29-24)18-25(31)12-20-6-3-2-4-7-20/h2-11,13-15,19,25H,12,16-18H2,1H3,(H,28,29)
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n/an/a 7.90n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092361
PNG
(4-Acetyl-3-benzyl-1-(3H-imidazol-4-ylmethyl)-2,3,4...)
Show SMILES CC(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C23H23N5O/c1-17(29)28-13-20-9-19(11-24)7-8-23(20)27(14-21-12-25-16-26-21)15-22(28)10-18-5-3-2-4-6-18/h2-9,12,16,22H,10,13-15H2,1H3,(H,25,26)/t22-/m1/s1
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n/an/a 8.75n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092364
PNG
(3-Benzyl-7-bromo-1-(3H-imidazol-4-ylmethyl)-4-meth...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1
Show InChI InChI=1S/C21H23BrN4O2S/c1-29(27,28)26-12-17-10-18(22)7-8-21(17)25(13-19-11-23-15-24-19)14-20(26)9-16-5-3-2-4-6-16/h2-8,10-11,15,20H,9,12-14H2,1H3,(H,23,24)/t20-/m1/s1
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n/an/a 10.7n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092355
PNG
(3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfo...)
Show SMILES CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)-c1ccncc1
Show InChI InChI=1S/C26H27N5O2S/c1-34(32,33)31-16-23-14-22(21-9-11-27-12-10-21)7-8-26(23)30(17-24-15-28-19-29-24)18-25(31)13-20-5-3-2-4-6-20/h2-12,14-15,19,25H,13,16-18H2,1H3,(H,28,29)/t25-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092367
PNG
(3-Benzyl-7-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,...)
Show SMILES CN(C)C(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C24H26N6O/c1-28(2)24(31)30-14-20-10-19(12-25)8-9-23(20)29(15-21-13-26-17-27-21)16-22(30)11-18-6-4-3-5-7-18/h3-10,13,17,22H,11,14-16H2,1-2H3,(H,26,27)/t22-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092368
PNG
(7-Bromo-3-(2-chloro-benzyl)-1-(3H-imidazol-4-ylmet...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1Cl
Show InChI InChI=1S/C21H22BrClN4O2S/c1-30(28,29)27-11-16-8-17(22)6-7-21(16)26(12-18-10-24-14-25-18)13-19(27)9-15-4-2-3-5-20(15)23/h2-8,10,14,19H,9,11-13H2,1H3,(H,24,25)
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092373
PNG
(3-Benzyl-7-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,...)
Show SMILES CCOC(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C24H25N5O2/c1-2-31-24(30)29-14-20-10-19(12-25)8-9-23(20)28(15-21-13-26-17-27-21)16-22(29)11-18-6-4-3-5-7-18/h3-10,13,17,22H,2,11,14-16H2,1H3,(H,26,27)/t22-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092356
PNG
(7-Bromo-3-cyclohexylmethyl-1-(3H-imidazol-4-ylmeth...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)C[C@H]1CC1CCCCC1
Show InChI InChI=1S/C21H29BrN4O2S/c1-29(27,28)26-12-17-10-18(22)7-8-21(17)25(13-19-11-23-15-24-19)14-20(26)9-16-5-3-2-4-6-16/h7-8,10-11,15-16,20H,2-6,9,12-14H2,1H3,(H,23,24)/t20-/m1/s1
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n/an/a 23.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092374
PNG
(7-Bromo-3-(3-chloro-benzyl)-1-(3H-imidazol-4-ylmet...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1Cc1cccc(Cl)c1
Show InChI InChI=1S/C21H22BrClN4O2S/c1-30(28,29)27-11-16-9-17(22)5-6-21(16)26(12-19-10-24-14-25-19)13-20(27)8-15-3-2-4-18(23)7-15/h2-7,9-10,14,20H,8,11-13H2,1H3,(H,24,25)
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n/an/a 24n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092378
PNG
(3-Benzyl-7-bromo-1-(3H-imidazol-4-ylmethyl)-4-meth...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1
Show InChI InChI=1S/C21H23BrN4O2S/c1-29(27,28)26-12-17-10-18(22)7-8-21(17)25(13-19-11-23-15-24-19)14-20(26)9-16-5-3-2-4-6-16/h2-8,10-11,15,20H,9,12-14H2,1H3,(H,23,24)
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n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092369
PNG
(7-Bromo-1-(3H-imidazol-4-ylmethyl)-4-methanesulfon...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1CCc1ccccc1
Show InChI InChI=1S/C22H25BrN4O2S/c1-30(28,29)27-13-18-11-19(23)8-10-22(18)26(14-20-12-24-16-25-20)15-21(27)9-7-17-5-3-2-4-6-17/h2-6,8,10-12,16,21H,7,9,13-15H2,1H3,(H,24,25)
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n/an/a 45n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092381
PNG
(1-[7-Bromo-1-(3H-imidazol-4-ylmethyl)-3-naphthalen...)
Show SMILES CC(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1Cc1cccc2ccccc12
Show InChI InChI=1S/C26H25BrN4O/c1-18(32)31-14-21-11-22(27)9-10-26(21)30(15-23-13-28-17-29-23)16-24(31)12-20-7-4-6-19-5-2-3-8-25(19)20/h2-11,13,17,24H,12,14-16H2,1H3,(H,28,29)
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n/an/a 54.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092370
PNG
(3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfo...)
Show SMILES CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C27H28N4O2S/c1-34(32,33)31-17-24-15-23(22-10-6-3-7-11-22)12-13-27(24)30(18-25-16-28-20-29-25)19-26(31)14-21-8-4-2-5-9-21/h2-13,15-16,20,26H,14,17-19H2,1H3,(H,28,29)
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n/an/a 54.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092362
PNG
(1-[3-Benzyl-7-bromo-1-(3H-imidazol-4-ylmethyl)-1,2...)
Show SMILES CC(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1
Show InChI InChI=1S/C22H23BrN4O/c1-16(28)27-12-18-10-19(23)7-8-22(18)26(13-20-11-24-15-25-20)14-21(27)9-17-5-3-2-4-6-17/h2-8,10-11,15,21H,9,12-14H2,1H3,(H,24,25)
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n/an/a 60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092360
PNG
(CHEMBL119993 | N-[7-Bromo-1-(3H-imidazol-4-ylmethy...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1CNC(=O)c1ccccc1
Show InChI InChI=1S/C22H24BrN5O3S/c1-32(30,31)28-12-17-9-18(23)7-8-21(17)27(13-19-10-24-15-26-19)14-20(28)11-25-22(29)16-5-3-2-4-6-16/h2-10,15,20H,11-14H2,1H3,(H,24,26)(H,25,29)
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n/an/a 86n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092379
PNG
(7-Bromo-1-(3H-imidazol-4-ylmethyl)-4-methanesulfon...)
Show SMILES COc1ccc(CC2CN(Cc3cnc[nH]3)c3ccc(Br)cc3CN2S(C)(=O)=O)cc1
Show InChI InChI=1S/C22H25BrN4O3S/c1-30-21-6-3-16(4-7-21)9-20-14-26(13-19-11-24-15-25-19)22-8-5-18(23)10-17(22)12-27(20)31(2,28)29/h3-8,10-11,15,20H,9,12-14H2,1-2H3,(H,24,25)
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n/an/a 101n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50083431
PNG
(CHEMBL121010 | [7-Bromo-1-(3H-imidazol-4-ylmethyl)...)
Show SMILES Brc1ccc2N(Cc3cnc[nH]3)CCN(Cc2c1)C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H21BrN4O/c25-19-8-9-23-18(12-19)14-29(11-10-28(23)15-20-13-26-16-27-20)24(30)22-7-3-5-17-4-1-2-6-21(17)22/h1-9,12-13,16H,10-11,14-15H2,(H,26,27)
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n/an/a 228n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092359
PNG
(CHEMBL118496 | [3-Benzyl-1-(3H-imidazol-4-ylmethyl...)
Show SMILES O=C(N1Cc2ccccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1)c1cccc2ccccc12
Show InChI InChI=1S/C31H28N4O/c36-31(29-15-8-13-24-11-4-6-14-28(24)29)35-19-25-12-5-7-16-30(25)34(20-26-18-32-22-33-26)21-27(35)17-23-9-2-1-3-10-23/h1-16,18,22,27H,17,19-21H2,(H,32,33)
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n/an/a 276n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092358
PNG
(1-(3H-Imidazol-4-ylmethyl)-4-methanesulfonyl-7-phe...)
Show SMILES CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccncc1)-c1ccccc1
Show InChI InChI=1S/C26H27N5O2S/c1-34(32,33)31-16-23-14-22(21-5-3-2-4-6-21)7-8-26(23)30(17-24-15-28-19-29-24)18-25(31)13-20-9-11-27-12-10-20/h2-12,14-15,19,25H,13,16-18H2,1H3,(H,28,29)/t25-/m1/s1
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n/an/a 383n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092376
PNG
(3-Benzyl-7-bromo-1-(3H-imidazol-4-ylmethyl)-4-meth...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)C[C@@H]1Cc1ccccc1
Show InChI InChI=1S/C21H23BrN4O2S/c1-29(27,28)26-12-17-10-18(22)7-8-21(17)25(13-19-11-23-15-24-19)14-20(26)9-16-5-3-2-4-6-16/h2-8,10-11,15,20H,9,12-14H2,1H3,(H,23,24)/t20-/m0/s1
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n/an/a 437n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50083439
PNG
(CHEMBL358680 | [1-(1H-Imidazol-4-ylmethyl)-1,2,3,5...)
Show SMILES O=C(N1CCN(Cc2cnc[nH]2)c2ccccc2C1)c1cccc2ccccc12
Show InChI InChI=1S/C24H22N4O/c29-24(22-10-5-8-18-6-1-3-9-21(18)22)28-13-12-27(16-20-14-25-17-26-20)23-11-4-2-7-19(23)15-28/h1-11,14,17H,12-13,15-16H2,(H,25,26)
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n/an/a 456n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092380
PNG
(CHEMBL118896 | [1-(3H-Imidazol-4-ylmethyl)-3-methy...)
Show SMILES CC1CN(Cc2cnc[nH]2)c2ccccc2CN1C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C25H24N4O/c1-18-14-28(16-21-13-26-17-27-21)24-12-5-3-8-20(24)15-29(18)25(30)23-11-6-9-19-7-2-4-10-22(19)23/h2-13,17-18H,14-16H2,1H3,(H,26,27)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092382
PNG
(1-[7-Bromo-1-(3H-imidazol-4-ylmethyl)-3-naphthalen...)
Show SMILES CC(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1Cc1ccc2ccccc2c1
Show InChI InChI=1S/C26H25BrN4O/c1-18(32)31-14-22-12-23(27)8-9-26(22)30(15-24-13-28-17-29-24)16-25(31)11-19-6-7-20-4-2-3-5-21(20)10-19/h2-10,12-13,17,25H,11,14-16H2,1H3,(H,28,29)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50092365
PNG
((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Show SMILES O=S(=O)(N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N)c1cccs1
Show InChI InChI=1S/C25H23N5O2S2/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22/h1-11,14,18,23H,12,15-17H2,(H,27,28)/t23-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of geranylgeranyl transferase (GGT1) using Ras-CVLL as substrate

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))		BDBM50092383
PNG
(1-[3-Benzyl-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tet...)
Show SMILES CC(=O)N1Cc2ccccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1
Show InChI InChI=1S/C22H24N4O/c1-17(27)26-13-19-9-5-6-10-22(19)25(14-20-12-23-16-24-20)15-21(26)11-18-7-3-2-4-8-18/h2-10,12,16,21H,11,13-15H2,1H3,(H,23,24)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50092365
PNG
((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Show SMILES O=S(=O)(N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N)c1cccs1
Show InChI InChI=1S/C25H23N5O2S2/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22/h1-11,14,18,23H,12,15-17H2,(H,27,28)/t23-/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of geranylgeranyl transferase (GGT1) using K-Ras as substrate

J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%