Affinity Data by PubMed id=14998320

PubMed code 14998320

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50140791 (1-(3-Bromo-4-cyano-2-hydroxy-phenyl)-3-(2-bromo-ph...) Show SMILES Oc1c(NC(=O)Nc2ccccc2Br)ccc(C#N)c1Br Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50140795 (1-(2-Bromo-phenyl)-3-(3-chloro-4-cyano-2-hydroxy-p...) Show SMILES Oc1c(Cl)c(ccc1NC(=O)Nc1ccccc1Br)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50140796 (1-(2-Bromo-phenyl)-3-(4-cyano-2-hydroxy-phenyl)-ur...) Show SMILES Oc1cc(ccc1NC(=O)Nc1ccccc1Br)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50140789 (1-(2-Bromo-phenyl)-3-(4-chloro-3-cyano-2-hydroxy-p...) Show SMILES Oc1c(NC(=O)Nc2ccccc2Br)ccc(Cl)c1C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50140792 (1-(4-Cyano-2-hydroxy-phenyl)-3-phenyl-urea \| 1-(4-...) Show SMILES Oc1cc(ccc1NC(=O)Nc1ccccc1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50140794 (1-(2-Hydroxy-4-nitro-phenyl)-3-phenyl-urea \| 1-(2-...) Show SMILES Oc1cc(ccc1NC(=O)Nc1ccccc1)[N+]([O-])=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50140793 (1-(2-Hydroxy-3-nitro-phenyl)-3-phenyl-urea \| CHEMB...) Show SMILES Oc1c(NC(=O)Nc2ccccc2)cccc1[N+]([O-])=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50140791 (1-(3-Bromo-4-cyano-2-hydroxy-phenyl)-3-(2-bromo-ph...) Show SMILES Oc1c(NC(=O)Nc2ccccc2Br)ccc(C#N)c1Br Show InChI	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 1 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50140795 (1-(2-Bromo-phenyl)-3-(3-chloro-4-cyano-2-hydroxy-p...) Show SMILES Oc1c(Cl)c(ccc1NC(=O)Nc1ccccc1Br)C#N Show InChI	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 1 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50140790 (1-(2-Hydroxy-5-nitro-phenyl)-3-phenyl-urea \| CHEMB...) Show SMILES Oc1ccc(cc1NC(=O)Nc1ccccc1)[N+]([O-])=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 2 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50140789 (1-(2-Bromo-phenyl)-3-(4-chloro-3-cyano-2-hydroxy-p...) Show SMILES Oc1c(NC(=O)Nc2ccccc2Br)ccc(Cl)c1C#N Show InChI	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.11E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 1 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50140796 (1-(2-Bromo-phenyl)-3-(4-cyano-2-hydroxy-phenyl)-ur...) Show SMILES Oc1cc(ccc1NC(=O)Nc1ccccc1Br)C#N Show InChI	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 1 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50140794 (1-(2-Hydroxy-4-nitro-phenyl)-3-phenyl-urea \| 1-(2-...) Show SMILES Oc1cc(ccc1NC(=O)Nc1ccccc1)[N+]([O-])=O Show InChI	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 1 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50140792 (1-(4-Cyano-2-hydroxy-phenyl)-3-phenyl-urea \| 1-(4-...) Show SMILES Oc1cc(ccc1NC(=O)Nc1ccccc1)C#N Show InChI	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 1 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50140793 (1-(2-Hydroxy-3-nitro-phenyl)-3-phenyl-urea \| CHEMB...) Show SMILES Oc1c(NC(=O)Nc2ccccc2)cccc1[N+]([O-])=O Show InChI	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 1 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50140790 (1-(2-Hydroxy-5-nitro-phenyl)-3-phenyl-urea \| CHEMB...) Show SMILES Oc1ccc(cc1NC(=O)Nc1ccccc1)[N+]([O-])=O Show InChI	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.62E+4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of binding of IL-8 to membranes of cloned CXC chemokine receptor 1 expressed in CHO Cells using [125I]-IL-8 radioligand				J Med Chem 47: 1319-21 (2004) Article DOI: 10.1021/jm034248l BindingDB Entry DOI: 10.7270/Q29G5M7Q
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%