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PubMed code 17869100

Compile data set for download or QSAR
Found 76 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222142
PNG
((S,E)-2-amino-N-(2-(benzyloxy)-1-(1-cinnamyl-1H-te...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C\C=C\c1ccccc1
Show InChI InChI=1S/C23H28N6O2/c1-23(2,24)22(30)25-20(17-31-16-19-12-7-4-8-13-19)21-26-27-28-29(21)15-9-14-18-10-5-3-6-11-18/h3-14,20H,15-17,24H2,1-2H3,(H,25,30)/b14-9+/t20-/m1/s1
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 190n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222164
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(3-phenylpropyl)...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1
Show InChI InChI=1S/C23H30N6O2/c1-23(2,24)22(30)25-20(17-31-16-19-12-7-4-8-13-19)21-26-27-28-29(21)15-9-14-18-10-5-3-6-11-18/h3-8,10-13,20H,9,14-17,24H2,1-2H3,(H,25,30)/t20-/m1/s1
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 200n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222147
PNG
((S)-benzyl 5-(5-(1-(2-amino-2-methylpropanamido)-2...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1
Show InChI InChI=1S/C27H37N7O4/c1-27(2,28)25(35)30-23(20-37-18-21-12-6-3-7-13-21)24-31-32-33-34(24)17-11-5-10-16-29-26(36)38-19-22-14-8-4-9-15-22/h3-4,6-9,12-15,23H,5,10-11,16-20,28H2,1-2H3,(H,29,36)(H,30,35)/t23-/m1/s1
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 320n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222136
PNG
(CHEMBL235793 | methyl 2-(5-((S)-1-(2-amino-2-methy...)
Show SMILES COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N |w:4.3|
Show InChI InChI=1S/C23H28N6O4/c1-23(2,24)22(31)25-18(15-33-14-16-10-6-4-7-11-16)20-26-27-28-29(20)19(21(30)32-3)17-12-8-5-9-13-17/h4-13,18-19H,14-15,24H2,1-3H3,(H,25,31)/t18-,19?/m1/s1
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 470n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222157
PNG
(2-amino-N-{(S)-2-benzyloxy-1-[1-(2-phenethylcarbam...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1
Show InChI InChI=1S/C25H33N7O3/c1-25(2,26)24(34)28-21(18-35-17-20-11-7-4-8-12-20)23-29-30-31-32(23)16-14-22(33)27-15-13-19-9-5-3-6-10-19/h3-12,21H,13-18,26H2,1-2H3,(H,27,33)(H,28,34)/t21-/m1/s1
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 780n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222166
PNG
(2-amino-N-((S)-2-benzyloxy-1-{1-[2-(3-phenyl-propy...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1
Show InChI InChI=1S/C26H35N7O3/c1-26(2,27)25(35)29-22(19-36-18-21-12-7-4-8-13-21)24-30-31-32-33(24)17-15-23(34)28-16-9-14-20-10-5-3-6-11-20/h3-8,10-13,22H,9,14-19,27H2,1-2H3,(H,28,34)(H,29,35)/t22-/m1/s1
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 820n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222162
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(2-(1-(methylsul...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O
Show InChI InChI=1S/C25H31N7O4S/c1-25(2,26)24(33)27-21(17-36-16-18-9-5-4-6-10-18)23-28-29-30-31(23)14-13-20-15-19-11-7-8-12-22(19)32(20)37(3,34)35/h4-12,15,21H,13-14,16-17,26H2,1-3H3,(H,27,33)/t21-/m1/s1
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 970n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222167
PNG
(2-amino-N-{(S)-1-[1-(2-benzylcarbamoyl-ethyl)-1H-t...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1
Show InChI InChI=1S/C24H31N7O3/c1-24(2,25)23(33)27-20(17-34-16-19-11-7-4-8-12-19)22-28-29-30-31(22)14-13-21(32)26-15-18-9-5-3-6-10-18/h3-12,20H,13-17,25H2,1-2H3,(H,26,32)(H,27,33)/t20-/m1/s1
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 1.07E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222173
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(2-(2-(1-(methylsul...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1
Show InChI InChI=1S/C25H31N7O4S/c1-25(2,26)24(33)27-21(17-36-16-18-9-5-4-6-10-18)23-28-30-31(29-23)14-13-20-15-19-11-7-8-12-22(19)32(20)37(3,34)35/h4-12,15,21H,13-14,16-17,26H2,1-3H3,(H,27,33)/t21-/m1/s1
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 1.27E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222150
PNG
(2-amino-N-{(R)-1-[1-(2-butylcarbamoyl-ethyl)-1H-te...)
Show SMILES CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N
Show InChI InChI=1S/C21H33N7O2/c1-4-5-14-23-18(29)13-15-28-19(25-26-27-28)17(24-20(30)21(2,3)22)12-11-16-9-7-6-8-10-16/h6-10,17H,4-5,11-15,22H2,1-3H3,(H,23,29)(H,24,30)/t17-/m1/s1
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 1.37E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222151
PNG
(2-amino-N-((S)-2-(benzyloxy)-1-(1-((1-(methylsulfo...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(c2ccccc12)S(C)(=O)=O |w:23.24|
Show InChI InChI=1S/C24H31N7O4S/c1-24(2,25)23(32)26-20(16-35-15-17-9-5-4-6-10-17)22-27-28-29-30(22)13-18-14-31(36(3,33)34)21-12-8-7-11-19(18)21/h4-12,18,20H,13-16,25H2,1-3H3,(H,26,32)/t18?,20-/m1/s1
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 1.59E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222161
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(3-(2-(N-methylm...)
Show SMILES CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O
Show InChI InChI=1S/C25H35N7O4S/c1-25(2,26)24(33)27-21(18-36-17-19-11-6-5-7-12-19)23-28-29-30-32(23)16-10-14-20-13-8-9-15-22(20)31(3)37(4,34)35/h5-9,11-13,15,21H,10,14,16-18,26H2,1-4H3,(H,27,33)/t21-/m1/s1
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 1.72E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222146
PNG
((S)-4-(5-(1-(2-amino-2-methylpropanamido)-2-(benzy...)
Show SMILES CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N
Show InChI InChI=1S/C22H35N7O3/c1-4-5-13-24-19(30)12-9-14-29-20(26-27-28-29)18(25-21(31)22(2,3)23)16-32-15-17-10-7-6-8-11-17/h6-8,10-11,18H,4-5,9,12-16,23H2,1-3H3,(H,24,30)(H,25,31)/t18-/m1/s1
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 1.78E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222153
PNG
((S)-2-amino-N-(1-(1-benzyl-1H-tetrazol-5-yl)-2-(be...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1
Show InChI InChI=1S/C21H26N6O2/c1-21(2,22)20(28)23-18(15-29-14-17-11-7-4-8-12-17)19-24-25-26-27(19)13-16-9-5-3-6-10-16/h3-12,18H,13-15,22H2,1-2H3,(H,23,28)/t18-/m1/s1
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 1.90E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222165
PNG
(2-amino-N-{(S)-2-benzyloxy-1-[1-(2-butylcarbamoyl-...)
Show SMILES CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N
Show InChI InChI=1S/C21H33N7O3/c1-4-5-12-23-18(29)11-13-28-19(25-26-27-28)17(24-20(30)21(2,3)22)15-31-14-16-9-7-6-8-10-16/h6-10,17H,4-5,11-15,22H2,1-3H3,(H,23,29)(H,24,30)/t17-/m1/s1
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 2.19E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222143
PNG
((S)-N-(1-(1-(2-(methylsulfonamido)phenethyl)-1H-te...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O
Show InChI InChI=1S/C23H31N7O4S/c1-23(2,24)22(31)25-20(16-34-15-17-9-5-4-6-10-17)21-26-28-29-30(21)14-13-18-11-7-8-12-19(18)27-35(3,32)33/h4-12,20,27H,13-16,24H2,1-3H3,(H,25,31)/t20-/m1/s1
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 2.20E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222172
PNG
((S)-methyl 4-(5-(1-(2-amino-2-methylpropanamido)-2...)
Show SMILES COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N
Show InChI InChI=1S/C19H28N6O4/c1-19(2,20)18(27)21-15(13-29-12-14-8-5-4-6-9-14)17-22-23-24-25(17)11-7-10-16(26)28-3/h4-6,8-9,15H,7,10-13,20H2,1-3H3,(H,21,27)/t15-/m1/s1
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 2.38E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222158
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(2-(3-(2-(methylsul...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1
Show InChI InChI=1S/C24H33N7O4S/c1-24(2,25)23(32)26-21(17-35-16-18-10-5-4-6-11-18)22-27-30-31(28-22)15-9-13-19-12-7-8-14-20(19)29-36(3,33)34/h4-8,10-12,14,21,29H,9,13,15-17,25H2,1-3H3,(H,26,32)/t21-/m1/s1
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 2.39E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222139
PNG
((S)-N-(1-(2-(2-(methylsulfonamido)phenethyl)-2H-te...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1
Show InChI InChI=1S/C23H31N7O4S/c1-23(2,24)22(31)25-20(16-34-15-17-9-5-4-6-10-17)21-26-29-30(27-21)14-13-18-11-7-8-12-19(18)28-35(3,32)33/h4-12,20,28H,13-16,24H2,1-3H3,(H,25,31)/t20-/m1/s1
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 2.66E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222148
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(2-cyanoethyl)-1...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N |r|
Show InChI InChI=1S/C17H23N7O2/c1-17(2,19)16(25)20-14(12-26-11-13-7-4-3-5-8-13)15-21-22-23-24(15)10-6-9-18/h3-5,7-8,14H,6,10-12,19H2,1-2H3,(H,20,25)/t14-/m1/s1
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 2.94E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222156
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(4-cyanobutyl)-1...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N
Show InChI InChI=1S/C19H27N7O2/c1-19(2,21)18(27)22-16(14-28-13-15-9-5-3-6-10-15)17-23-24-25-26(17)12-8-4-7-11-20/h3,5-6,9-10,16H,4,7-8,12-14,21H2,1-2H3,(H,22,27)/t16-/m1/s1
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 3.12E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222171
PNG
((S)-methyl 3-(5-(1-(2-amino-2-methylpropanamido)-2...)
Show SMILES COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N
Show InChI InChI=1S/C18H26N6O4/c1-18(2,19)17(26)20-14(12-28-11-13-7-5-4-6-8-13)16-21-22-23-24(16)10-9-15(25)27-3/h4-8,14H,9-12,19H2,1-3H3,(H,20,26)/t14-/m1/s1
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 3.38E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222149
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(cyanomethyl)-1H...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N
Show InChI InChI=1S/C16H21N7O2/c1-16(2,18)15(24)19-13(14-20-21-22-23(14)9-8-17)11-25-10-12-6-4-3-5-7-12/h3-7,13H,9-11,18H2,1-2H3,(H,19,24)/t13-/m1/s1
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 4.17E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222141
PNG
((S)-N-(1-(1-(2-(methylsulfonamido)benzyl)-1H-tetra...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O
Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-16-9-5-4-6-10-16)20-25-27-28-29(20)13-17-11-7-8-12-18(17)26-34(3,31)32/h4-12,19,26H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
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 4.45E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222168
PNG
((S)-2-amino-N-(1-(2-benzyl-2H-tetrazol-5-yl)-2-(be...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1
Show InChI InChI=1S/C21H26N6O2/c1-21(2,22)20(28)23-18(15-29-14-17-11-7-4-8-12-17)19-24-26-27(25-19)13-16-9-5-3-6-10-16/h3-12,18H,13-15,22H2,1-2H3,(H,23,28)/t18-/m1/s1
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 4.75E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222159
PNG
((S)-N-(1-(1-(3-(methylsulfonamido)benzyl)-1H-tetra...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1
Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-16-8-5-4-6-9-16)20-25-27-28-29(20)13-17-10-7-11-18(12-17)26-34(3,31)32/h4-12,19,26H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222137
PNG
((S)-N-(1-(1-(2-(1H-tetrazol-5-yl)ethyl)-1H-tetrazo...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1
Show InChI InChI=1S/C17H24N10O2/c1-17(2,18)16(28)19-13(11-29-10-12-6-4-3-5-7-12)15-22-25-26-27(15)9-8-14-20-23-24-21-14/h3-7,13H,8-11,18H2,1-2H3,(H,19,28)(H,20,21,23,24)/t13-/m1/s1
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 5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222144
PNG
((S)-N-(1-(2-(3-(methylsulfonamido)benzyl)-2H-tetra...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1
Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-16-8-5-4-6-9-16)20-25-28-29(26-20)13-17-10-7-11-18(12-17)27-34(3,31)32/h4-12,19,27H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222155
PNG
((S)-N-(1-(2-(2-(methylsulfonamido)benzyl)-2H-tetra...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1
Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-16-9-5-4-6-10-16)20-25-28-29(26-20)13-17-11-7-8-12-18(17)27-34(3,31)32/h4-12,19,27H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222170
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(5-(methylsulfon...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O
Show InChI InChI=1S/C20H33N7O4S/c1-20(2,21)19(28)23-17(15-31-14-16-10-6-4-7-11-16)18-24-25-26-27(18)13-9-5-8-12-22-32(3,29)30/h4,6-7,10-11,17,22H,5,8-9,12-15,21H2,1-3H3,(H,23,28)/t17-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222160
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(2-(cyanomethyl)-2H...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1
Show InChI InChI=1S/C16H21N7O2/c1-16(2,18)15(24)19-13(14-20-22-23(21-14)9-8-17)11-25-10-12-6-4-3-5-7-12/h3-7,13H,9-11,18H2,1-2H3,(H,19,24)/t13-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222154
PNG
((S)-N-(1-(1-(4-(methylsulfonamido)benzyl)-1H-tetra...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-17-7-5-4-6-8-17)20-25-27-28-29(20)13-16-9-11-18(12-10-16)26-34(3,31)32/h4-12,19,26H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222152
PNG
(2-amino-N-((S)-2-(benzyloxy)-1-(2-((1-(methylsulfo...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1 |w:22.22|
Show InChI InChI=1S/C24H31N7O4S/c1-24(2,25)23(32)26-20(16-35-15-17-9-5-4-6-10-17)22-27-29-30(28-22)14-19-13-18-11-7-8-12-21(18)31(19)36(3,33)34/h4-12,19-20H,13-16,25H2,1-3H3,(H,26,32)/t19?,20-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222140
PNG
((S,E)-2-amino-N-(2-(benzyloxy)-1-(2-cinnamyl-2H-te...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C\C=C\c2ccccc2)n1
Show InChI InChI=1S/C23H28N6O2/c1-23(2,24)22(30)25-20(17-31-16-19-12-7-4-8-13-19)21-26-28-29(27-21)15-9-14-18-10-5-3-6-11-18/h3-14,20H,15-17,24H2,1-2H3,(H,25,30)/b14-9+/t20-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222169
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(2-(4-cyanobutyl)-2...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1
Show InChI InChI=1S/C19H27N7O2/c1-19(2,21)18(27)22-16(14-28-13-15-9-5-3-6-10-15)17-23-25-26(24-17)12-8-4-7-11-20/h3,5-6,9-10,16H,4,7-8,12-14,21H2,1-2H3,(H,22,27)/t16-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222145
PNG
(CHEMBL237060 | methyl 2-(5-((S)-1-(2-amino-2-methy...)
Show SMILES COC(=O)C(c1ccccc1)n1nnc(n1)[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N |w:4.11|
Show InChI InChI=1S/C23H28N6O4/c1-23(2,24)22(31)25-18(15-33-14-16-10-6-4-7-11-16)20-26-28-29(27-20)19(21(30)32-3)17-12-8-5-9-13-17/h4-13,18-19H,14-15,24H2,1-3H3,(H,25,31)/t18-,19?/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222163
PNG
((S)-N-(1-(2-(4-(methylsulfonamido)benzyl)-2H-tetra...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1
Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-17-7-5-4-6-8-17)20-25-28-29(26-20)13-16-9-11-18(12-10-16)27-34(3,31)32/h4-12,19,27H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222138
PNG
((R)-methyl 3-(5-(1-(2-amino-2-methylpropanamido)-2...)
Show SMILES COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N
Show InChI InChI=1S/C19H25N7O3/c1-19(2,20)18(28)22-15(10-12-11-21-14-7-5-4-6-13(12)14)17-23-24-25-26(17)9-8-16(27)29-3/h4-7,11,15,21H,8-10,20H2,1-3H3,(H,22,28)/t15-/m1/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Ghrelin from human GHSR1a after 1 hr

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222172
PNG
((S)-methyl 4-(5-(1-(2-amino-2-methylpropanamido)-2...)
Show SMILES COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N
Show InChI InChI=1S/C19H28N6O4/c1-19(2,20)18(27)21-15(13-29-12-14-8-5-4-6-9-14)17-22-23-24-25(17)11-7-10-16(26)28-3/h4-6,8-9,15H,7,10-13,20H2,1-3H3,(H,21,27)/t15-/m1/s1
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n/an/an/an/a 55n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222163
PNG
((S)-N-(1-(2-(4-(methylsulfonamido)benzyl)-2H-tetra...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1
Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-17-7-5-4-6-8-17)20-25-28-29(26-20)13-16-9-11-18(12-10-16)27-34(3,31)32/h4-12,19,27H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
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n/an/an/an/a 986n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222173
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(2-(2-(1-(methylsul...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1
Show InChI InChI=1S/C25H31N7O4S/c1-25(2,26)24(33)27-21(17-36-16-18-9-5-4-6-10-18)23-28-30-31(29-23)14-13-20-15-19-11-7-8-12-22(19)32(20)37(3,34)35/h4-12,15,21H,13-14,16-17,26H2,1-3H3,(H,27,33)/t21-/m1/s1
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n/an/an/an/a 150n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222171
PNG
((S)-methyl 3-(5-(1-(2-amino-2-methylpropanamido)-2...)
Show SMILES COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N
Show InChI InChI=1S/C18H26N6O4/c1-18(2,19)17(26)20-14(12-28-11-13-7-5-4-6-8-13)16-21-22-23-24(16)10-9-15(25)27-3/h4-8,14H,9-12,19H2,1-3H3,(H,20,26)/t14-/m1/s1
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n/an/an/an/a 43n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222149
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(cyanomethyl)-1H...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N
Show InChI InChI=1S/C16H21N7O2/c1-16(2,18)15(24)19-13(14-20-21-22-23(14)9-8-17)11-25-10-12-6-4-3-5-7-12/h3-7,13H,9-11,18H2,1-2H3,(H,19,24)/t13-/m1/s1
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n/an/an/an/a 29n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222164
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(3-phenylpropyl)...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1
Show InChI InChI=1S/C23H30N6O2/c1-23(2,24)22(30)25-20(17-31-16-19-12-7-4-8-13-19)21-26-27-28-29(21)15-9-14-18-10-5-3-6-11-18/h3-8,10-13,20H,9,14-17,24H2,1-2H3,(H,25,30)/t20-/m1/s1
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n/an/an/an/a 17n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222170
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(5-(methylsulfon...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O
Show InChI InChI=1S/C20H33N7O4S/c1-20(2,21)19(28)23-17(15-31-14-16-10-6-4-7-11-16)18-24-25-26-27(18)13-9-5-8-12-22-32(3,29)30/h4,6-7,10-11,17,22H,5,8-9,12-15,21H2,1-3H3,(H,23,28)/t17-/m1/s1
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n/an/an/an/a 75n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222153
PNG
((S)-2-amino-N-(1-(1-benzyl-1H-tetrazol-5-yl)-2-(be...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1
Show InChI InChI=1S/C21H26N6O2/c1-21(2,22)20(28)23-18(15-29-14-17-11-7-4-8-12-17)19-24-25-26-27(19)13-16-9-5-3-6-10-16/h3-12,18H,13-15,22H2,1-2H3,(H,23,28)/t18-/m1/s1
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n/an/an/an/a 99n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222159
PNG
((S)-N-(1-(1-(3-(methylsulfonamido)benzyl)-1H-tetra...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1
Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-16-8-5-4-6-9-16)20-25-27-28-29(20)13-17-10-7-11-18(12-17)26-34(3,31)32/h4-12,19,26H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
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n/an/an/an/a 116n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222154
PNG
((S)-N-(1-(1-(4-(methylsulfonamido)benzyl)-1H-tetra...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-17-7-5-4-6-8-17)20-25-27-28-29(20)13-16-9-11-18(12-10-16)26-34(3,31)32/h4-12,19,26H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
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n/an/an/an/a 259n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222144
PNG
((S)-N-(1-(2-(3-(methylsulfonamido)benzyl)-2H-tetra...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1
Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-16-8-5-4-6-9-16)20-25-28-29(26-20)13-17-10-7-11-18(12-17)27-34(3,31)32/h4-12,19,27H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
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n/an/an/an/a 868n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222145
PNG
(CHEMBL237060 | methyl 2-(5-((S)-1-(2-amino-2-methy...)
Show SMILES COC(=O)C(c1ccccc1)n1nnc(n1)[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N |w:4.11|
Show InChI InChI=1S/C23H28N6O4/c1-23(2,24)22(31)25-18(15-33-14-16-10-6-4-7-11-16)20-26-28-29(27-20)19(21(30)32-3)17-12-8-5-9-13-17/h4-13,18-19H,14-15,24H2,1-3H3,(H,25,31)/t18-,19?/m1/s1
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n/an/an/an/a 3.17E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222151
PNG
(2-amino-N-((S)-2-(benzyloxy)-1-(1-((1-(methylsulfo...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(c2ccccc12)S(C)(=O)=O |w:23.24|
Show InChI InChI=1S/C24H31N7O4S/c1-24(2,25)23(32)26-20(16-35-15-17-9-5-4-6-10-17)22-27-28-29-30(22)13-18-14-31(36(3,33)34)21-12-8-7-11-19(18)21/h4-12,18,20H,13-16,25H2,1-3H3,(H,26,32)/t18?,20-/m1/s1
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n/an/an/an/a 147n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222138
PNG
((R)-methyl 3-(5-(1-(2-amino-2-methylpropanamido)-2...)
Show SMILES COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N
Show InChI InChI=1S/C19H25N7O3/c1-19(2,20)18(28)22-15(10-12-11-21-14-7-5-4-6-13(12)14)17-23-24-25-26(17)9-8-16(27)29-3/h4-7,11,15,21H,8-10,20H2,1-3H3,(H,22,28)/t15-/m1/s1
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n/an/an/an/a 200n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222147
PNG
((S)-benzyl 5-(5-(1-(2-amino-2-methylpropanamido)-2...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1
Show InChI InChI=1S/C27H37N7O4/c1-27(2,28)25(35)30-23(20-37-18-21-12-6-3-7-13-21)24-31-32-33-34(24)17-11-5-10-16-29-26(36)38-19-22-14-8-4-9-15-22/h3-4,6-9,12-15,23H,5,10-11,16-20,28H2,1-2H3,(H,29,36)(H,30,35)/t23-/m1/s1
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n/an/an/an/a 10n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222142
PNG
((S,E)-2-amino-N-(2-(benzyloxy)-1-(1-cinnamyl-1H-te...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C\C=C\c1ccccc1
Show InChI InChI=1S/C23H28N6O2/c1-23(2,24)22(30)25-20(17-31-16-19-12-7-4-8-13-19)21-26-27-28-29(21)15-9-14-18-10-5-3-6-11-18/h3-14,20H,15-17,24H2,1-2H3,(H,25,30)/b14-9+/t20-/m1/s1
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n/an/an/an/a 12n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222162
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(2-(1-(methylsul...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O
Show InChI InChI=1S/C25H31N7O4S/c1-25(2,26)24(33)27-21(17-36-16-18-9-5-4-6-10-18)23-28-29-30-31(23)14-13-20-15-19-11-7-8-12-22(19)32(20)37(3,34)35/h4-12,15,21H,13-14,16-17,26H2,1-3H3,(H,27,33)/t21-/m1/s1
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n/an/an/an/a 4n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222165
PNG
(2-amino-N-{(S)-2-benzyloxy-1-[1-(2-butylcarbamoyl-...)
Show SMILES CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N
Show InChI InChI=1S/C21H33N7O3/c1-4-5-12-23-18(29)11-13-28-19(25-26-27-28)17(24-20(30)21(2,3)22)15-31-14-16-9-7-6-8-10-16/h6-10,17H,4-5,11-15,22H2,1-3H3,(H,23,29)(H,24,30)/t17-/m1/s1
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n/an/an/an/a 42n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222139
PNG
((S)-N-(1-(2-(2-(methylsulfonamido)phenethyl)-2H-te...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1
Show InChI InChI=1S/C23H31N7O4S/c1-23(2,24)22(31)25-20(16-34-15-17-9-5-4-6-10-17)21-26-29-30(27-21)14-13-18-11-7-8-12-19(18)28-35(3,32)33/h4-12,20,28H,13-16,24H2,1-3H3,(H,25,31)/t20-/m1/s1
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n/an/an/an/a 4.11E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222150
PNG
(2-amino-N-{(R)-1-[1-(2-butylcarbamoyl-ethyl)-1H-te...)
Show SMILES CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N
Show InChI InChI=1S/C21H33N7O2/c1-4-5-14-23-18(29)13-15-28-19(25-26-27-28)17(24-20(30)21(2,3)22)12-11-16-9-7-6-8-10-16/h6-10,17H,4-5,11-15,22H2,1-3H3,(H,23,29)(H,24,30)/t17-/m1/s1
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n/an/an/an/a 49n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222141
PNG
((S)-N-(1-(1-(2-(methylsulfonamido)benzyl)-1H-tetra...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O
Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-16-9-5-4-6-10-16)20-25-27-28-29(20)13-17-11-7-8-12-18(17)26-34(3,31)32/h4-12,19,26H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
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n/an/an/an/a 390n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222136
PNG
(CHEMBL235793 | methyl 2-(5-((S)-1-(2-amino-2-methy...)
Show SMILES COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N |w:4.3|
Show InChI InChI=1S/C23H28N6O4/c1-23(2,24)22(31)25-18(15-33-14-16-10-6-4-7-11-16)20-26-27-28-29(20)19(21(30)32-3)17-12-8-5-9-13-17/h4-13,18-19H,14-15,24H2,1-3H3,(H,25,31)/t18-,19?/m1/s1
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n/an/an/an/a 20n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222157
PNG
(2-amino-N-{(S)-2-benzyloxy-1-[1-(2-phenethylcarbam...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1
Show InChI InChI=1S/C25H33N7O3/c1-25(2,26)24(34)28-21(18-35-17-20-11-7-4-8-12-20)23-29-30-31-32(23)16-14-22(33)27-15-13-19-9-5-3-6-10-19/h3-12,21H,13-18,26H2,1-2H3,(H,27,33)(H,28,34)/t21-/m1/s1
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n/an/an/an/a 27n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222166
PNG
(2-amino-N-((S)-2-benzyloxy-1-{1-[2-(3-phenyl-propy...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1
Show InChI InChI=1S/C26H35N7O3/c1-26(2,27)25(35)29-22(19-36-18-21-12-7-4-8-13-21)24-30-31-32-33(24)17-15-23(34)28-16-9-14-20-10-5-3-6-11-20/h3-8,10-13,22H,9,14-19,27H2,1-2H3,(H,28,34)(H,29,35)/t22-/m1/s1
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n/an/an/an/a 59n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222160
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(2-(cyanomethyl)-2H...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1
Show InChI InChI=1S/C16H21N7O2/c1-16(2,18)15(24)19-13(14-20-22-23(21-14)9-8-17)11-25-10-12-6-4-3-5-7-12/h3-7,13H,9-11,18H2,1-2H3,(H,19,24)/t13-/m1/s1
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n/an/an/an/a 1.52E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222158
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(2-(3-(2-(methylsul...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1
Show InChI InChI=1S/C24H33N7O4S/c1-24(2,25)23(32)26-21(17-35-16-18-10-5-4-6-11-18)22-27-30-31(28-22)15-9-13-19-12-7-8-14-20(19)29-36(3,33)34/h4-8,10-12,14,21,29H,9,13,15-17,25H2,1-3H3,(H,26,32)/t21-/m1/s1
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n/an/an/an/a 107n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222143
PNG
((S)-N-(1-(1-(2-(methylsulfonamido)phenethyl)-1H-te...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O
Show InChI InChI=1S/C23H31N7O4S/c1-23(2,24)22(31)25-20(16-34-15-17-9-5-4-6-10-17)21-26-28-29-30(21)14-13-18-11-7-8-12-19(18)27-35(3,32)33/h4-12,20,27H,13-16,24H2,1-3H3,(H,25,31)/t20-/m1/s1
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n/an/an/an/a 67n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222140
PNG
((S,E)-2-amino-N-(2-(benzyloxy)-1-(2-cinnamyl-2H-te...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C\C=C\c2ccccc2)n1
Show InChI InChI=1S/C23H28N6O2/c1-23(2,24)22(30)25-20(17-31-16-19-12-7-4-8-13-19)21-26-28-29(27-21)15-9-14-18-10-5-3-6-11-18/h3-14,20H,15-17,24H2,1-2H3,(H,25,30)/b14-9+/t20-/m1/s1
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n/an/an/an/a 517n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222168
PNG
((S)-2-amino-N-(1-(2-benzyl-2H-tetrazol-5-yl)-2-(be...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1
Show InChI InChI=1S/C21H26N6O2/c1-21(2,22)20(28)23-18(15-29-14-17-11-7-4-8-12-17)19-24-26-27(25-19)13-16-9-5-3-6-10-16/h3-12,18H,13-15,22H2,1-2H3,(H,23,28)/t18-/m1/s1
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n/an/an/an/a 1.12E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222148
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(2-cyanoethyl)-1...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N |r|
Show InChI InChI=1S/C17H23N7O2/c1-17(2,19)16(25)20-14(12-26-11-13-7-4-3-5-8-13)15-21-22-23-24(15)10-6-9-18/h3-5,7-8,14H,6,10-12,19H2,1-2H3,(H,20,25)/t14-/m1/s1
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n/an/an/an/a 30n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222146
PNG
((S)-4-(5-(1-(2-amino-2-methylpropanamido)-2-(benzy...)
Show SMILES CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N
Show InChI InChI=1S/C22H35N7O3/c1-4-5-13-24-19(30)12-9-14-29-20(26-27-28-29)18(25-21(31)22(2,3)23)16-32-15-17-10-7-6-8-11-17/h6-8,10-11,18H,4-5,9,12-16,23H2,1-3H3,(H,24,30)(H,25,31)/t18-/m1/s1
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n/an/an/an/a 30n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222169
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(2-(4-cyanobutyl)-2...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1
Show InChI InChI=1S/C19H27N7O2/c1-19(2,21)18(27)22-16(14-28-13-15-9-5-3-6-10-15)17-23-25-26(24-17)12-8-4-7-11-20/h3,5-6,9-10,16H,4,7-8,12-14,21H2,1-2H3,(H,22,27)/t16-/m1/s1
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n/an/an/an/a 1.86E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222167
PNG
(2-amino-N-{(S)-1-[1-(2-benzylcarbamoyl-ethyl)-1H-t...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1
Show InChI InChI=1S/C24H31N7O3/c1-24(2,25)23(33)27-20(17-34-16-19-11-7-4-8-12-19)22-28-29-30-31(22)14-13-21(32)26-15-18-9-5-3-6-10-18/h3-12,20H,13-17,25H2,1-2H3,(H,26,32)(H,27,33)/t20-/m1/s1
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n/an/an/an/a 51n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222161
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(3-(2-(N-methylm...)
Show SMILES CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O
Show InChI InChI=1S/C25H35N7O4S/c1-25(2,26)24(33)27-21(18-36-17-19-11-6-5-7-12-19)23-28-29-30-32(23)16-10-14-20-13-8-9-15-22(20)31(3)37(4,34)35/h5-9,11-13,15,21H,10,14,16-18,26H2,1-4H3,(H,27,33)/t21-/m1/s1
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n/an/an/an/a 14n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222152
PNG
(2-amino-N-((S)-2-(benzyloxy)-1-(2-((1-(methylsulfo...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1 |w:22.22|
Show InChI InChI=1S/C24H31N7O4S/c1-24(2,25)23(32)26-20(16-35-15-17-9-5-4-6-10-17)22-27-29-30(28-22)14-19-13-18-11-7-8-12-21(18)31(19)36(3,33)34/h4-12,19-20H,13-16,25H2,1-3H3,(H,26,32)/t19?,20-/m1/s1
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n/an/an/an/a 546n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222155
PNG
((S)-N-(1-(2-(2-(methylsulfonamido)benzyl)-2H-tetra...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1
Show InChI InChI=1S/C22H29N7O4S/c1-22(2,23)21(30)24-19(15-33-14-16-9-5-4-6-10-16)20-25-28-29(26-20)13-17-11-7-8-12-18(17)27-34(3,31)32/h4-12,19,27H,13-15,23H2,1-3H3,(H,24,30)/t19-/m1/s1
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n/an/an/an/a 426n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222137
PNG
((S)-N-(1-(1-(2-(1H-tetrazol-5-yl)ethyl)-1H-tetrazo...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1
Show InChI InChI=1S/C17H24N10O2/c1-17(2,18)16(28)19-13(11-29-10-12-6-4-3-5-7-12)15-22-25-26-27(15)9-8-14-20-23-24-21-14/h3-7,13H,8-11,18H2,1-2H3,(H,19,28)(H,20,21,23,24)/t13-/m1/s1
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n/an/an/an/a 347n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50222156
PNG
((S)-2-amino-N-(2-(benzyloxy)-1-(1-(4-cyanobutyl)-1...)
Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N
Show InChI InChI=1S/C19H27N7O2/c1-19(2,21)18(27)22-16(14-28-13-15-9-5-3-6-10-15)17-23-24-25-26(17)12-8-4-7-11-20/h3,5-6,9-10,16H,4,7-8,12-14,21H2,1-2H3,(H,22,27)/t16-/m1/s1
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n/an/an/an/a 35n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay

Bioorg Med Chem Lett 17: 5928-33 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.099
BindingDB Entry DOI: 10.7270/Q28P607D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%