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PubMed code 19665384

Compile data set for download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304109
PNG
((Z)-5'-Nitro-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Show SMILES [O-][N+](=O)c1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H10N4O4/c21-16-13(10-7-8(20(23)24)5-6-12(10)18-16)15-14(19-22)9-3-1-2-4-11(9)17-15/h1-7,13,17H,(H,18,21)
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n/an/a 6n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304111
PNG
(CHEMBL593698 | N-((Z)-3,2'-Dioxo-1,3,1',2'-tetrahy...)
Show SMILES CC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4C3=O)c2c1
Show InChI InChI=1S/C18H13N3O3/c1-9(22)19-10-6-7-14-12(8-10)15(18(24)21-14)16-17(23)11-4-2-3-5-13(11)20-16/h2-8,20H,1H3,(H,19,22)(H,21,24)/b16-15-
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n/an/a 18n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304121
PNG
((Z)-5-Bromo-5'-nitro-1H,1'H-[2,3']biindolylidene-3...)
Show SMILES [O-][N+](=O)c1ccc2NC(=O)C(c2c1)c1[nH]c2ccc(Br)cc2c1N=O
Show InChI InChI=1S/C16H9BrN4O4/c17-7-1-3-12-10(5-7)14(20-23)15(18-12)13-9-6-8(21(24)25)2-4-11(9)19-16(13)22/h1-6,13,18H,(H,19,22)
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n/an/a 50n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304113
PNG
(CHEMBL604270 | N-((Z)-5-Bromo-3,2'-dioxo-1,3,1',2'...)
Show SMILES CC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccc(Br)cc4C3=O)c2c1
Show InChI InChI=1S/C18H12BrN3O3/c1-8(23)20-10-3-5-13-11(7-10)15(18(25)22-13)16-17(24)12-6-9(19)2-4-14(12)21-16/h2-7,21H,1H3,(H,20,23)(H,22,25)/b16-15-
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n/an/a 110n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50423711
PNG
(CHEMBL594403)
Show SMILES O[N-]c1c([nH]c2ccccc12)C1=c2ccc(cc2=[NH+]C1=O)[N+]([O-])=O |c:13,20|
Show InChI InChI=1S/C16H10N4O4/c21-16-13(9-6-5-8(20(23)24)7-12(9)18-16)15-14(19-22)10-3-1-2-4-11(10)17-15/h1-7H,(H3,17,18,19,21,22)
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n/an/a 120n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304112
PNG
((Z)-5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Show SMILES Nc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H12N4O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)15-14(20-22)9-3-1-2-4-11(9)18-15/h1-7,13,18H,17H2,(H,19,21)
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n/an/a 150n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304114
PNG
(CHEMBL445348 | N-{(Z)-3-[(E)-Hydroxyimino]-2'-oxo-...)
Show SMILES CC(=O)Nc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C18H14N4O3/c1-9(23)19-10-6-7-14-12(8-10)15(18(24)21-14)17-16(22-25)11-4-2-3-5-13(11)20-17/h2-8,15,20H,1H3,(H,19,23)(H,21,24)
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n/an/a 160n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50423712
PNG
(CHEMBL593968)
Show SMILES Nc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H12N4O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,13,18H,17H2,(H,19,21)
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n/an/a 200n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50423713
PNG
(CHEMBL606982)
Show SMILES O[N-]c1c([nH]c2ccc(Br)cc12)C1=c2ccc(cc2=[NH+]C1=O)[N+]([O-])=O |c:14,21|
Show InChI InChI=1S/C16H9BrN4O4/c17-7-1-4-11-10(5-7)14(20-23)15(18-11)13-9-3-2-8(21(24)25)6-12(9)19-16(13)22/h1-6H,(H3,18,19,20,22,23)
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n/an/a 300n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304119
PNG
((Z)-5'-Amino-5-bromo-1H,1'H-[2,3']biindolylidene-3...)
Show SMILES Nc1ccc2NC(=O)C(=C3Nc4ccc(Br)cc4C3=O)c2c1 |w:9.19|
Show InChI InChI=1S/C16H10BrN3O2/c17-7-1-3-12-10(5-7)15(21)14(19-12)13-9-6-8(18)2-4-11(9)20-16(13)22/h1-6,19H,18H2,(H,20,22)
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n/an/a 550n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304110
PNG
((Z)-5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Show SMILES Nc1ccc2NC(=O)C(=C3Nc4ccccc4C3=O)c2c1 |w:9.18|
Show InChI InChI=1S/C16H11N3O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)14-15(20)9-3-1-2-4-11(9)18-14/h1-7,18H,17H2,(H,19,21)
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n/an/a 590n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304123
PNG
((Z)-5'-Amino-5-bromo-1H,1'H-[2,3']biindolylidene-3...)
Show SMILES Nc1ccc2NC(=O)C(c2c1)c1[nH]c2ccc(Br)cc2c1N=O
Show InChI InChI=1S/C16H11BrN4O2/c17-7-1-3-12-10(5-7)14(21-23)15(19-12)13-9-6-8(18)2-4-11(9)20-16(13)22/h1-6,13,19H,18H2,(H,20,22)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304109
PNG
((Z)-5'-Nitro-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Show SMILES [O-][N+](=O)c1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H10N4O4/c21-16-13(10-7-8(20(23)24)5-6-12(10)18-16)15-14(19-22)9-3-1-2-4-11(9)17-15/h1-7,13,17H,(H,18,21)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304111
PNG
(CHEMBL593698 | N-((Z)-3,2'-Dioxo-1,3,1',2'-tetrahy...)
Show SMILES CC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccccc4C3=O)c2c1
Show InChI InChI=1S/C18H13N3O3/c1-9(22)19-10-6-7-14-12(8-10)15(18(24)21-14)16-17(23)11-4-2-3-5-13(11)20-16/h2-8,20H,1H3,(H,19,22)(H,21,24)/b16-15-
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n/an/a 2.50E+3n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304110
PNG
((Z)-5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Show SMILES Nc1ccc2NC(=O)C(=C3Nc4ccccc4C3=O)c2c1 |w:9.18|
Show InChI InChI=1S/C16H11N3O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)14-15(20)9-3-1-2-4-11(9)18-14/h1-7,18H,17H2,(H,19,21)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304124
PNG
(CHEMBL594857 | N-{(Z)-5-Bromo-3-[(E)-hydroxyimino]...)
Show SMILES CC(=O)Nc1ccc2NC(=O)C(c2c1)c1[nH]c2ccc(Br)cc2c1N=O
Show InChI InChI=1S/C18H13BrN4O3/c1-8(24)20-10-3-5-13-11(7-10)15(18(25)22-13)17-16(23-26)12-6-9(19)2-4-14(12)21-17/h2-7,15,21H,1H3,(H,20,24)(H,22,25)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50423714
PNG
((2''Z)-6-Aminoindirubin | CHEMBL609580)
Show SMILES Nc1ccc2C(C(=O)Nc2c1)=C1Nc2ccccc2C1=O |w:11.22|
Show InChI InChI=1S/C16H11N3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)14-15(20)10-3-1-2-4-11(10)18-14/h1-7,18H,17H2,(H,19,21)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304112
PNG
((Z)-5'-Amino-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Show SMILES Nc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H12N4O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)15-14(20-22)9-3-1-2-4-11(9)18-15/h1-7,13,18H,17H2,(H,19,21)
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n/an/a 4.20E+3n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304113
PNG
(CHEMBL604270 | N-((Z)-5-Bromo-3,2'-dioxo-1,3,1',2'...)
Show SMILES CC(=O)Nc1ccc2NC(=O)\C(=C3/Nc4ccc(Br)cc4C3=O)c2c1
Show InChI InChI=1S/C18H12BrN3O3/c1-8(23)20-10-3-5-13-11(7-10)15(18(25)22-13)16-17(24)12-6-9(19)2-4-14(12)21-16/h2-7,21H,1H3,(H,20,23)(H,22,25)/b16-15-
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n/an/a 7.30E+3n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304122
PNG
((Z)-5,7'-Dibromo-5'-nitro-1H,1'H-[2,3']biindolylid...)
Show SMILES [O-][N+](=O)c1cc2C(C(=O)Nc2c(Br)c1)c1[nH]c2ccc(Br)cc2c1N=O
Show InChI InChI=1S/C16H8Br2N4O4/c17-6-1-2-11-8(3-6)14(21-24)15(19-11)12-9-4-7(22(25)26)5-10(18)13(9)20-16(12)23/h1-5,12,19H,(H,20,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304123
PNG
((Z)-5'-Amino-5-bromo-1H,1'H-[2,3']biindolylidene-3...)
Show SMILES Nc1ccc2NC(=O)C(c2c1)c1[nH]c2ccc(Br)cc2c1N=O
Show InChI InChI=1S/C16H11BrN4O2/c17-7-1-3-12-10(5-7)14(21-23)15(19-12)13-9-6-8(18)2-4-11(9)20-16(13)22/h1-6,13,19H,18H2,(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304124
PNG
(CHEMBL594857 | N-{(Z)-5-Bromo-3-[(E)-hydroxyimino]...)
Show SMILES CC(=O)Nc1ccc2NC(=O)C(c2c1)c1[nH]c2ccc(Br)cc2c1N=O
Show InChI InChI=1S/C18H13BrN4O3/c1-8(24)20-10-3-5-13-11(7-10)15(18(25)22-13)17-16(23-26)12-6-9(19)2-4-14(12)21-17/h2-7,15,21H,1H3,(H,20,24)(H,22,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50423716
PNG
(CHEMBL606865)
Show SMILES [O-][N+](=O)c1ccc2[c-](C3=[NH+]c4ccc(Br)cc4C3=O)c(=O)[nH]c2c1 |t:8|
Show InChI InChI=1S/C16H7BrN3O4/c17-7-1-4-11-10(5-7)15(21)14(18-11)13-9-3-2-8(20(23)24)6-12(9)19-16(13)22/h1-6H,(H,19,22)/q-1/p+1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304117
PNG
((2'Z)-5'-7-Dibromo-5-nitroindirubin | CHEMBL606814)
Show SMILES [O-][N+](=O)c1cc(Br)c2[nH]c(=O)[c-](C3=[NH+]c4ccc(Br)cc4C3=O)c2c1 |t:12|
Show InChI InChI=1S/C16H6Br2N3O4/c17-6-1-2-11-8(3-6)15(22)14(19-11)12-9-4-7(21(24)25)5-10(18)13(9)20-16(12)23/h1-5H,(H,20,23)/q-1/p+1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304117
PNG
((2'Z)-5'-7-Dibromo-5-nitroindirubin | CHEMBL606814)
Show SMILES [O-][N+](=O)c1cc(Br)c2[nH]c(=O)[c-](C3=[NH+]c4ccc(Br)cc4C3=O)c2c1 |t:12|
Show InChI InChI=1S/C16H6Br2N3O4/c17-6-1-2-11-8(3-6)15(22)14(19-11)12-9-4-7(21(24)25)5-10(18)13(9)20-16(12)23/h1-5H,(H,20,23)/q-1/p+1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304118
PNG
((Z)-5-Bromo-5'-nitro-1H,1'H-[2,3']biindolylidene-3...)
Show SMILES [O-][N+](=O)c1ccc2[nH]c(=O)[c-](C3=[NH+]c4ccc(Br)cc4C3=O)c2c1 |t:11|
Show InChI InChI=1S/C16H7BrN3O4/c17-7-1-3-12-10(5-7)15(21)14(18-12)13-9-6-8(20(23)24)2-4-11(9)19-16(13)22/h1-6H,(H,19,22)/q-1/p+1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304115
PNG
((2'Z)-7-Bromo-5-nitroindirubin | CHEMBL605926)
Show SMILES [O-]c1c([nH]c2ccccc12)C1=c2cc(cc(Br)c2=[NH+]C1=O)[N+]([O-])=O |c:12,20|
Show InChI InChI=1S/C16H8BrN3O4/c17-10-6-7(20(23)24)5-9-12(16(22)19-13(9)10)14-15(21)8-3-1-2-4-11(8)18-14/h1-6,18,21H
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304116
PNG
((Z)-5'-Nitro-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Show SMILES [O-]c1c([nH]c2ccccc12)C1=c2cc(ccc2=[NH+]C1=O)[N+]([O-])=O |c:12,19|
Show InChI InChI=1S/C16H9N3O4/c20-15-9-3-1-2-4-11(9)17-14(15)13-10-7-8(19(22)23)5-6-12(10)18-16(13)21/h1-7,17,20H
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304120
PNG
((Z)-7'-Bromo-5'-nitro-1H,1'H-[2,3']biindolylidene-...)
Show SMILES [O-][N+](=O)c1cc2C(C(=O)Nc2c(Br)c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H9BrN4O4/c17-10-6-7(21(24)25)5-9-12(16(22)19-13(9)10)15-14(20-23)8-3-1-2-4-11(8)18-15/h1-6,12,18H,(H,19,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304122
PNG
((Z)-5,7'-Dibromo-5'-nitro-1H,1'H-[2,3']biindolylid...)
Show SMILES [O-][N+](=O)c1cc2C(C(=O)Nc2c(Br)c1)c1[nH]c2ccc(Br)cc2c1N=O
Show InChI InChI=1S/C16H8Br2N4O4/c17-6-1-2-11-8(3-6)14(21-24)15(19-11)12-9-4-7(22(25)26)5-10(18)13(9)20-16(12)23/h1-5,12,19H,(H,20,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50423715
PNG
((2''Z)-6-Nitroindirubin | CHEMBL593700)
Show SMILES [O-][N+](=O)c1ccc2[c-](C3=[NH+]c4ccccc4C3=O)c(=O)[nH]c2c1 |t:8|
Show InChI InChI=1S/C16H8N3O4/c20-15-10-3-1-2-4-11(10)17-14(15)13-9-6-5-8(19(22)23)7-12(9)18-16(13)21/h1-7H,(H,18,21)/q-1/p+1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304120
PNG
((Z)-7'-Bromo-5'-nitro-1H,1'H-[2,3']biindolylidene-...)
Show SMILES [O-][N+](=O)c1cc2C(C(=O)Nc2c(Br)c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H9BrN4O4/c17-10-6-7(21(24)25)5-9-12(16(22)19-13(9)10)15-14(20-23)8-3-1-2-4-11(8)18-15/h1-6,12,18H,(H,19,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304118
PNG
((Z)-5-Bromo-5'-nitro-1H,1'H-[2,3']biindolylidene-3...)
Show SMILES [O-][N+](=O)c1ccc2[nH]c(=O)[c-](C3=[NH+]c4ccc(Br)cc4C3=O)c2c1 |t:11|
Show InChI InChI=1S/C16H7BrN3O4/c17-7-1-3-12-10(5-7)15(21)14(18-12)13-9-6-8(20(23)24)2-4-11(9)19-16(13)22/h1-6H,(H,19,22)/q-1/p+1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304119
PNG
((Z)-5'-Amino-5-bromo-1H,1'H-[2,3']biindolylidene-3...)
Show SMILES Nc1ccc2NC(=O)C(=C3Nc4ccc(Br)cc4C3=O)c2c1 |w:9.19|
Show InChI InChI=1S/C16H10BrN3O2/c17-7-1-3-12-10(5-7)15(21)14(19-12)13-9-6-8(18)2-4-11(9)20-16(13)22/h1-6,19H,18H2,(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304121
PNG
((Z)-5-Bromo-5'-nitro-1H,1'H-[2,3']biindolylidene-3...)
Show SMILES [O-][N+](=O)c1ccc2NC(=O)C(c2c1)c1[nH]c2ccc(Br)cc2c1N=O
Show InChI InChI=1S/C16H9BrN4O4/c17-7-1-3-12-10(5-7)14(20-23)15(18-12)13-9-6-8(21(24)25)2-4-11(9)19-16(13)22/h1-6,13,18H,(H,19,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304115
PNG
((2'Z)-7-Bromo-5-nitroindirubin | CHEMBL605926)
Show SMILES [O-]c1c([nH]c2ccccc12)C1=c2cc(cc(Br)c2=[NH+]C1=O)[N+]([O-])=O |c:12,20|
Show InChI InChI=1S/C16H8BrN3O4/c17-10-6-7(20(23)24)5-9-12(16(22)19-13(9)10)14-15(21)8-3-1-2-4-11(8)18-14/h1-6,18,21H
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A


(RAT)		BDBM50304114
PNG
(CHEMBL445348 | N-{(Z)-3-[(E)-Hydroxyimino]-2'-oxo-...)
Show SMILES CC(=O)Nc1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C18H14N4O3/c1-9(23)19-10-6-7-14-12(8-10)15(18(24)21-14)17-16(22-25)11-4-2-3-5-13(11)20-17/h2-8,15,20H,1H3,(H,19,23)(H,21,24)
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n/an/a 1.50E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation ...

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50304116
PNG
((Z)-5'-Nitro-1H,1'H-[2,3']biindolylidene-3,2'-dion...)
Show SMILES [O-]c1c([nH]c2ccccc12)C1=c2cc(ccc2=[NH+]C1=O)[N+]([O-])=O |c:12,19|
Show InChI InChI=1S/C16H9N3O4/c20-15-9-3-1-2-4-11(9)17-14(15)13-10-7-8(19(22)23)5-6-12(10)18-16(13)21/h1-7,17,20H
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n/an/a 2.50E+4n/an/an/an/an/an/a



Universit£ de La Rochelle

Curated by ChEMBL


Assay Description
Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting

Bioorg Med Chem 17: 6257-63 (2009)


Article DOI: 10.1016/j.bmc.2009.07.051
BindingDB Entry DOI: 10.7270/Q2BR8S9W
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%