Affinity Data by PubMed id=24900662

PubMed code 24900662

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50426548 (CHEMBL2323956) Show SMILES C1c2ccccc2-c2n[nH]c(Nc3ccc4OCCOc4c3)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50426547 (CHEMBL2323957) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50226373 (1-(4-Amino-phenyl)-3-(3-benzo[1,3]dioxol-5-yl-4-ox...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	214	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50426549 (CHEMBL2323955) Show SMILES C1Oc2ccc(Nc3[nH]nc-4c3Cc3ccccc-43)cc2O1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM91950 (Chk1_82) Show SMILES COc1ccc(Nc2[nH]nc-3c2Cc2ccccc-32)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50095469 ((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol \|...) Show SMILES OCc1ccc(o1)-c1nn(Cc2ccccc2)c2ccccc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50426550 (CHEMBL2323954) Show SMILES COc1ccc(Nc2[nH]nc-3c2Cc2ccccc-32)cc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50426551 (CHEMBL2323953) Show SMILES COc1cccc(Nc2[nH]nc-3c2Cc2ccccc-32)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50400094 (CHEMBL427092) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50179209 ((6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-y...) Show SMILES COc1cc2Cc3c(Nc4ccccc4)[nH]nc3-c2cc1OC Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50179215 ((6-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)ph...) Show SMILES COc1ccc-2c(Cc3c(Nc4ccccc4)[nH]nc-23)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50426552 (CHEMBL2323951) Show SMILES C1Oc2cc3Cc4c(Nc5ccccc5)[nH]nc4-c3cc2O1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50179205 ((2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine ...) Show SMILES C1c2ccccc2-c2n[nH]c(Nc3ccccc3)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50426553 (CHEMBL2323950) Show SMILES COc1cccc2Cc3c(Nc4ccccc4)[nH]nc3-c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50179210 ((7-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)ph...) Show SMILES COc1ccc2Cc3c(Nc4ccccc4)[nH]nc3-c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50179213 ((5-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)ph...) Show SMILES COc1cccc-2c1Cc1c(Nc3ccccc3)[nH]nc-21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gakushuin University Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...				ACS Med Chem Lett 4: 297-301 (2013) Article DOI: 10.1021/ml3004632 BindingDB Entry DOI: 10.7270/Q2R212P9
Gakushuin University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%