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PubMed code 28927793

Compile data set for download or QSAR
Found 97 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261864
PNG
(CHEMBL4100435)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CC3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C18H18Cl2N4O/c19-12-8-13(17(21)25)23-18-15(12)16(20)14(6-5-10-3-4-10)24(18)11-2-1-7-22-9-11/h8,10-11,22H,1-4,7,9H2,(H2,21,25)
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n/an/a 0.700n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261828
PNG
(CHEMBL4095220)
Show SMILES NC1CCCC(C1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O
Show InChI InChI=1S/C14H15Cl2IN4O/c15-8-5-9(13(19)22)20-14-10(8)11(16)12(17)21(14)7-3-1-2-6(18)4-7/h5-7H,1-4,18H2,(H2,19,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261808
PNG
(CHEMBL4104355)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@H]3CCCNC3)c2n1 |r|
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)/t9-/m0/s1
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261857
PNG
(CHEMBL4082422)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261822
PNG
(CHEMBL4093592)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CC3CCNC3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-3-8(12(17)21)19-13-9(7)10(15)11(16)20(13)5-6-1-2-18-4-6/h3,6,18H,1-2,4-5H2,(H2,17,21)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis H37RV InhA

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261827
PNG
(CHEMBL4070441)
Show SMILES NC1CCC(CC1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O |(71.97,-24.68,;71.49,-23.21,;69.98,-22.89,;69.5,-21.44,;70.53,-20.3,;72.04,-20.6,;72.52,-22.06,;70.05,-18.83,;70.95,-17.58,;72.49,-17.57,;70.03,-16.34,;70.5,-14.87,;68.57,-16.82,;67.24,-16.06,;67.23,-14.52,;65.91,-16.83,;65.91,-18.37,;67.24,-19.15,;68.58,-18.37,;64.57,-19.14,;64.57,-20.68,;63.24,-18.37,)|
Show InChI InChI=1S/C14H15Cl2IN4O/c15-8-5-9(13(19)22)20-14-10(8)11(16)12(17)21(14)7-3-1-6(18)2-4-7/h5-7H,1-4,18H2,(H2,19,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261822
PNG
(CHEMBL4093592)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CC3CCNC3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-3-8(12(17)21)19-13-9(7)10(15)11(16)20(13)5-6-1-2-18-4-6/h3,6,18H,1-2,4-5H2,(H2,17,21)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261858
PNG
(CHEMBL4062258)
Show SMILES Cn1cc(cn1)-c1c(Cl)c2c(Cl)cc(nc2n1C1CCCNC1)C(N)=O
Show InChI InChI=1S/C17H18Cl2N6O/c1-24-8-9(6-22-24)15-14(19)13-11(18)5-12(16(20)26)23-17(13)25(15)10-3-2-4-21-7-10/h5-6,8,10,21H,2-4,7H2,1H3,(H2,20,26)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261829
PNG
(CHEMBL4067797)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCNCC3)c2n1
Show InChI InChI=1S/C14H15Cl2IN4O/c15-8-6-9(13(18)22)20-14-10(8)11(16)12(17)21(14)7-2-1-4-19-5-3-7/h6-7,19H,1-5H2,(H2,18,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261826
PNG
(CHEMBL4084988)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-4-8(12(17)21)19-13-9(7)10(15)11(16)20(13)6-2-1-3-18-5-6/h4,6,18H,1-3,5H2,(H2,17,21)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261873
PNG
(CHEMBL4070019)
Show SMILES CN1CCC(CC1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O
Show InChI InChI=1S/C14H15Cl2IN4O/c1-20-4-2-7(3-5-20)21-12(17)11(16)10-8(15)6-9(13(18)22)19-14(10)21/h6-7H,2-5H2,1H3,(H2,18,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261828
PNG
(CHEMBL4095220)
Show SMILES NC1CCCC(C1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O
Show InChI InChI=1S/C14H15Cl2IN4O/c15-8-5-9(13(19)22)20-14-10(8)11(16)12(17)21(14)7-3-1-2-6(18)4-7/h5-7H,1-4,18H2,(H2,19,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261825
PNG
(CHEMBL4077977)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCNCC3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-5-8(12(17)21)19-13-9(7)10(15)11(16)20(13)6-1-3-18-4-2-6/h5-6,18H,1-4H2,(H2,17,21)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261826
PNG
(CHEMBL4084988)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-4-8(12(17)21)19-13-9(7)10(15)11(16)20(13)6-2-1-3-18-5-6/h4,6,18H,1-3,5H2,(H2,17,21)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261827
PNG
(CHEMBL4070441)
Show SMILES NC1CCC(CC1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O |(71.97,-24.68,;71.49,-23.21,;69.98,-22.89,;69.5,-21.44,;70.53,-20.3,;72.04,-20.6,;72.52,-22.06,;70.05,-18.83,;70.95,-17.58,;72.49,-17.57,;70.03,-16.34,;70.5,-14.87,;68.57,-16.82,;67.24,-16.06,;67.23,-14.52,;65.91,-16.83,;65.91,-18.37,;67.24,-19.15,;68.58,-18.37,;64.57,-19.14,;64.57,-20.68,;63.24,-18.37,)|
Show InChI InChI=1S/C14H15Cl2IN4O/c15-8-5-9(13(19)22)20-14-10(8)11(16)12(17)21(14)7-3-1-6(18)2-4-7/h5-7H,1-4,18H2,(H2,19,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261854
PNG
(CHEMBL4075702)
Show SMILES CSc1c(Cl)c2c(Cl)cc(nc2n1C1CCCNC1)C(N)=O
Show InChI InChI=1S/C14H16Cl2N4OS/c1-22-14-11(16)10-8(15)5-9(12(17)21)19-13(10)20(14)7-3-2-4-18-6-7/h5,7,18H,2-4,6H2,1H3,(H2,17,21)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261874
PNG
(CHEMBL4064302)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CCC3CCNCC3)c2n1
Show InChI InChI=1S/C15H17Cl2IN4O/c16-9-7-10(14(19)23)21-15-11(9)12(17)13(18)22(15)6-3-8-1-4-20-5-2-8/h7-8,20H,1-6H2,(H2,19,23)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261829
PNG
(CHEMBL4067797)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCNCC3)c2n1
Show InChI InChI=1S/C14H15Cl2IN4O/c15-8-6-9(13(18)22)20-14-10(8)11(16)12(17)21(14)7-2-1-4-19-5-3-7/h6-7,19H,1-5H2,(H2,18,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261866
PNG
(CHEMBL4087517)
Show SMILES NCC1CCC(CC1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O |(25.89,-37.44,;26.91,-36.3,;26.43,-34.83,;24.93,-34.51,;24.45,-33.06,;25.48,-31.92,;26.98,-32.22,;27.46,-33.68,;24.99,-30.45,;25.89,-29.2,;27.43,-29.19,;24.98,-27.96,;25.44,-26.49,;23.51,-28.44,;22.18,-27.68,;22.17,-26.14,;20.85,-28.45,;20.85,-29.99,;22.18,-30.77,;23.52,-29.99,;19.51,-30.76,;19.51,-32.3,;18.18,-29.99,)|
Show InChI InChI=1S/C15H17Cl2IN4O/c16-9-5-10(14(20)23)21-15-11(9)12(17)13(18)22(15)8-3-1-7(6-19)2-4-8/h5,7-8H,1-4,6,19H2,(H2,20,23)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261856
PNG
(CHEMBL4071926)
Show SMILES [#6]\[#6](-[#6])=[#6]\c1c(Cl)c2c(Cl)cc(nc2n1-[#6]-1-[#6]-[#6]-[#6]-[#7]-[#6]-1)-[#6](-[#7])=O
Show InChI InChI=1S/C17H20Cl2N4O/c1-9(2)6-13-15(19)14-11(18)7-12(16(20)24)22-17(14)23(13)10-4-3-5-21-8-10/h6-7,10,21H,3-5,8H2,1-2H3,(H2,20,24)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis H37RV InhA

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261823
PNG
(CHEMBL4072887)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CC3CCNCC3)c2n1
Show InChI InChI=1S/C14H15Cl2IN4O/c15-8-5-9(13(18)22)20-14-10(8)11(16)12(17)21(14)6-7-1-3-19-4-2-7/h5,7,19H,1-4,6H2,(H2,18,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261807
PNG
(CHEMBL4086461)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@@H]3CCCNC3)c2n1 |r|
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)/t9-/m1/s1
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261825
PNG
(CHEMBL4077977)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCNCC3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-5-8(12(17)21)19-13-9(7)10(15)11(16)20(13)6-1-3-18-4-2-6/h5-6,18H,1-4H2,(H2,17,21)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261808
PNG
(CHEMBL4104355)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@H]3CCCNC3)c2n1 |r|
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)/t9-/m0/s1
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis H37RV InhA

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261826
PNG
(CHEMBL4084988)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-4-8(12(17)21)19-13-9(7)10(15)11(16)20(13)6-2-1-3-18-5-6/h4,6,18H,1-3,5H2,(H2,17,21)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261873
PNG
(CHEMBL4070019)
Show SMILES CN1CCC(CC1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O
Show InChI InChI=1S/C14H15Cl2IN4O/c1-20-4-2-7(3-5-20)21-12(17)11(16)10-8(15)6-9(13(18)22)19-14(10)21/h6-7H,2-5H2,1H3,(H2,18,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261864
PNG
(CHEMBL4100435)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CC3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C18H18Cl2N4O/c19-12-8-13(17(21)25)23-18-15(12)16(20)14(6-5-10-3-4-10)24(18)11-2-1-7-22-9-11/h8,10-11,22H,1-4,7,9H2,(H2,21,25)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261830
PNG
(CHEMBL4105379)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CN4CCC3CC4)c2n1 |(33.51,-30.79,;33.51,-29.25,;32.17,-28.49,;34.84,-28.49,;34.84,-26.94,;36.17,-26.17,;36.17,-24.63,;37.5,-26.94,;38.97,-26.45,;39.44,-24.98,;39.89,-27.69,;41.43,-27.68,;38.98,-28.95,;39.47,-30.41,;40.98,-30.71,;41.46,-32.18,;40.43,-33.33,;38.92,-33.01,;38.44,-31.55,;39.86,-31.35,;39.72,-32.56,;37.51,-28.48,;36.18,-29.26,)|
Show InChI InChI=1S/C15H15Cl2IN4O/c16-8-5-9(14(19)23)20-15-11(8)12(17)13(18)22(15)10-6-21-3-1-7(10)2-4-21/h5,7,10H,1-4,6H2,(H2,19,23)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261827
PNG
(CHEMBL4070441)
Show SMILES NC1CCC(CC1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O |(71.97,-24.68,;71.49,-23.21,;69.98,-22.89,;69.5,-21.44,;70.53,-20.3,;72.04,-20.6,;72.52,-22.06,;70.05,-18.83,;70.95,-17.58,;72.49,-17.57,;70.03,-16.34,;70.5,-14.87,;68.57,-16.82,;67.24,-16.06,;67.23,-14.52,;65.91,-16.83,;65.91,-18.37,;67.24,-19.15,;68.58,-18.37,;64.57,-19.14,;64.57,-20.68,;63.24,-18.37,)|
Show InChI InChI=1S/C14H15Cl2IN4O/c15-8-5-9(13(19)22)20-14-10(8)11(16)12(17)21(14)7-3-1-6(18)2-4-7/h5-7H,1-4,18H2,(H2,19,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261805
PNG
(CHEMBL4096630)
Show SMILES COC\C=C\c1c(Cl)c2c(Cl)cc(nc2n1C1CCCNC1)C(N)=O
Show InChI InChI=1S/C17H20Cl2N4O2/c1-25-7-3-5-13-15(19)14-11(18)8-12(16(20)24)22-17(14)23(13)10-4-2-6-21-9-10/h3,5,8,10,21H,2,4,6-7,9H2,1H3,(H2,20,24)/b5-3+
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261831
PNG
(CHEMBL4065094)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCC(O)CC3)c2n1 |(47.27,-30.19,;47.27,-28.65,;45.94,-27.88,;48.61,-27.88,;48.61,-26.34,;49.94,-25.57,;49.93,-24.03,;51.27,-26.33,;52.74,-25.85,;53.2,-24.38,;53.65,-27.09,;55.19,-27.08,;52.75,-28.34,;53.24,-29.8,;52.21,-30.94,;52.69,-32.4,;54.19,-32.72,;54.67,-34.18,;55.22,-31.57,;54.74,-30.1,;51.28,-27.87,;49.94,-28.65,)|
Show InChI InChI=1S/C14H14Cl2IN3O2/c15-8-5-9(13(18)22)19-14-10(8)11(16)12(17)20(14)6-1-3-7(21)4-2-6/h5-7,21H,1-4H2,(H2,18,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261832
PNG
(CHEMBL4086532)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCC(O)C3)c2n1
Show InChI InChI=1S/C14H14Cl2IN3O2/c15-8-5-9(13(18)22)19-14-10(8)11(16)12(17)20(14)6-2-1-3-7(21)4-6/h5-7,21H,1-4H2,(H2,18,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261866
PNG
(CHEMBL4087517)
Show SMILES NCC1CCC(CC1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O |(25.89,-37.44,;26.91,-36.3,;26.43,-34.83,;24.93,-34.51,;24.45,-33.06,;25.48,-31.92,;26.98,-32.22,;27.46,-33.68,;24.99,-30.45,;25.89,-29.2,;27.43,-29.19,;24.98,-27.96,;25.44,-26.49,;23.51,-28.44,;22.18,-27.68,;22.17,-26.14,;20.85,-28.45,;20.85,-29.99,;22.18,-30.77,;23.52,-29.99,;19.51,-30.76,;19.51,-32.3,;18.18,-29.99,)|
Show InChI InChI=1S/C15H17Cl2IN4O/c16-9-5-10(14(20)23)21-15-11(9)12(17)13(18)22(15)8-3-1-7(6-19)2-4-8/h5,7-8H,1-4,6,19H2,(H2,20,23)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261828
PNG
(CHEMBL4095220)
Show SMILES NC1CCCC(C1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O
Show InChI InChI=1S/C14H15Cl2IN4O/c15-8-5-9(13(19)22)20-14-10(8)11(16)12(17)21(14)7-3-1-2-6(18)4-7/h5-7H,1-4,18H2,(H2,19,22)
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n/an/a 10n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261823
PNG
(CHEMBL4072887)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CC3CCNCC3)c2n1
Show InChI InChI=1S/C14H15Cl2IN4O/c15-8-5-9(13(18)22)20-14-10(8)11(16)12(17)21(14)6-7-1-3-19-4-2-7/h5,7,19H,1-4,6H2,(H2,18,22)
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n/an/a 12n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261824
PNG
(CHEMBL4085846)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CC3CCCN3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-4-8(12(17)21)19-13-9(7)10(15)11(16)20(13)5-6-2-1-3-18-6/h4,6,18H,1-3,5H2,(H2,17,21)
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n/an/a 12n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261855
PNG
(CHEMBL4092706)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(-c3ccccc3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C19H18Cl2N4O/c20-13-9-14(18(22)26)24-19-15(13)16(21)17(11-5-2-1-3-6-11)25(19)12-7-4-8-23-10-12/h1-3,5-6,9,12,23H,4,7-8,10H2,(H2,22,26)
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n/an/a 13n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261857
PNG
(CHEMBL4082422)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)
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n/an/a 13n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261829
PNG
(CHEMBL4067797)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCNCC3)c2n1
Show InChI InChI=1S/C14H15Cl2IN4O/c15-8-6-9(13(18)22)20-14-10(8)11(16)12(17)21(14)7-2-1-4-19-5-3-7/h6-7,19H,1-5H2,(H2,18,22)
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n/an/a 15n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261854
PNG
(CHEMBL4075702)
Show SMILES CSc1c(Cl)c2c(Cl)cc(nc2n1C1CCCNC1)C(N)=O
Show InChI InChI=1S/C14H16Cl2N4OS/c1-22-14-11(16)10-8(15)5-9(12(17)21)19-13(10)20(14)7-3-2-4-18-6-7/h5,7,18H,2-4,6H2,1H3,(H2,17,21)
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n/an/a 15n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261858
PNG
(CHEMBL4062258)
Show SMILES Cn1cc(cn1)-c1c(Cl)c2c(Cl)cc(nc2n1C1CCCNC1)C(N)=O
Show InChI InChI=1S/C17H18Cl2N6O/c1-24-8-9(6-22-24)15-14(19)13-11(18)5-12(16(20)26)23-17(13)25(15)10-3-2-4-21-7-10/h5-6,8,10,21H,2-4,7H2,1H3,(H2,20,26)
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n/an/a 16n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261874
PNG
(CHEMBL4064302)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CCC3CCNCC3)c2n1
Show InChI InChI=1S/C15H17Cl2IN4O/c16-9-7-10(14(19)23)21-15-11(9)12(17)13(18)22(15)6-3-8-1-4-20-5-2-8/h7-8,20H,1-6H2,(H2,19,23)
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n/an/a 17n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261807
PNG
(CHEMBL4086461)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@@H]3CCCNC3)c2n1 |r|
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)/t9-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis H37RV InhA

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261822
PNG
(CHEMBL4093592)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CC3CCNC3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-3-8(12(17)21)19-13-9(7)10(15)11(16)20(13)5-6-1-2-18-4-6/h3,6,18H,1-2,4-5H2,(H2,17,21)
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n/an/a 23n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261856
PNG
(CHEMBL4071926)
Show SMILES [#6]\[#6](-[#6])=[#6]\c1c(Cl)c2c(Cl)cc(nc2n1-[#6]-1-[#6]-[#6]-[#6]-[#7]-[#6]-1)-[#6](-[#7])=O
Show InChI InChI=1S/C17H20Cl2N4O/c1-9(2)6-13-15(19)14-11(18)7-12(16(20)24)22-17(14)23(13)10-4-3-5-21-8-10/h6-7,10,21H,3-5,8H2,1-2H3,(H2,20,24)
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n/an/a 24n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261806
PNG
(CHEMBL4078609)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(n(C3CCCNC3)c2n1)C(F)(F)F
Show InChI InChI=1S/C14H13Cl2F3N4O/c15-7-4-8(12(20)24)22-13-9(7)10(16)11(14(17,18)19)23(13)6-2-1-3-21-5-6/h4,6,21H,1-3,5H2,(H2,20,24)
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n/an/a 25n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261831
PNG
(CHEMBL4065094)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCC(O)CC3)c2n1 |(47.27,-30.19,;47.27,-28.65,;45.94,-27.88,;48.61,-27.88,;48.61,-26.34,;49.94,-25.57,;49.93,-24.03,;51.27,-26.33,;52.74,-25.85,;53.2,-24.38,;53.65,-27.09,;55.19,-27.08,;52.75,-28.34,;53.24,-29.8,;52.21,-30.94,;52.69,-32.4,;54.19,-32.72,;54.67,-34.18,;55.22,-31.57,;54.74,-30.1,;51.28,-27.87,;49.94,-28.65,)|
Show InChI InChI=1S/C14H14Cl2IN3O2/c15-8-5-9(13(18)22)19-14-10(8)11(16)12(17)20(14)6-1-3-7(21)4-2-6/h5-7,21H,1-4H2,(H2,18,22)
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n/an/a 25n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261830
PNG
(CHEMBL4105379)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CN4CCC3CC4)c2n1 |(33.51,-30.79,;33.51,-29.25,;32.17,-28.49,;34.84,-28.49,;34.84,-26.94,;36.17,-26.17,;36.17,-24.63,;37.5,-26.94,;38.97,-26.45,;39.44,-24.98,;39.89,-27.69,;41.43,-27.68,;38.98,-28.95,;39.47,-30.41,;40.98,-30.71,;41.46,-32.18,;40.43,-33.33,;38.92,-33.01,;38.44,-31.55,;39.86,-31.35,;39.72,-32.56,;37.51,-28.48,;36.18,-29.26,)|
Show InChI InChI=1S/C15H15Cl2IN4O/c16-8-5-9(14(19)23)20-15-11(8)12(17)13(18)22(15)10-6-21-3-1-7(10)2-4-21/h5,7,10H,1-4,6H2,(H2,19,23)
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n/an/a 27n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261825
PNG
(CHEMBL4077977)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCNCC3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-5-8(12(17)21)19-13-9(7)10(15)11(16)20(13)6-1-3-18-4-2-6/h5-6,18H,1-4H2,(H2,17,21)
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n/an/a 28n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261832
PNG
(CHEMBL4086532)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCC(O)C3)c2n1
Show InChI InChI=1S/C14H14Cl2IN3O2/c15-8-5-9(13(18)22)19-14-10(8)11(16)12(17)20(14)6-2-1-3-7(21)4-6/h5-7,21H,1-4H2,(H2,18,22)
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n/an/a 28n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261865
PNG
(CHEMBL4073332)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CCCO3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C17H20Cl2N4O2/c18-10-7-11(16(20)24)22-17-13(10)14(19)15(12-4-2-6-25-12)23(17)9-3-1-5-21-8-9/h7,9,12,21H,1-6,8H2,(H2,20,24)
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n/an/a 31n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261863
PNG
(CHEMBL4061455)
Show SMILES Cn1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O
Show InChI InChI=1S/C9H6Cl2IN3O/c1-15-7(12)6(11)5-3(10)2-4(8(13)16)14-9(5)15/h2H,1H3,(H2,13,16)
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n/an/a 31n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261861
PNG
(CHEMBL4089255)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCNC(=O)C3)c2n1
Show InChI InChI=1S/C13H11Cl2IN4O2/c14-6-4-7(12(17)22)19-13-9(6)10(15)11(16)20(13)5-1-2-18-8(21)3-5/h4-5H,1-3H2,(H2,17,22)(H,18,21)
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n/an/a 32n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261873
PNG
(CHEMBL4070019)
Show SMILES CN1CCC(CC1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O
Show InChI InChI=1S/C14H15Cl2IN4O/c1-20-4-2-7(3-5-20)21-12(17)11(16)10-8(15)6-9(13(18)22)19-14(10)21/h6-7H,2-5H2,1H3,(H2,18,22)
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n/an/a 34n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261875
PNG
(CHEMBL4083330)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1c(C)c2c(Cl)cc(nc2n1C)C(N)=O
Show InChI InChI=1S/C21H24ClN5O/c1-13-18-16(22)12-17(20(23)28)24-21(18)26(3)19(13)14-4-6-15(7-5-14)27-10-8-25(2)9-11-27/h4-7,12H,8-11H2,1-3H3,(H2,23,28)
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n/an/a 37n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261859
PNG
(CHEMBL4090269)
Show SMILES COCC1CC1c1c(Cl)c2c(Cl)cc(nc2n1C1CCCNC1)C(N)=O
Show InChI InChI=1S/C18H22Cl2N4O2/c1-26-8-9-5-11(9)16-15(20)14-12(19)6-13(17(21)25)23-18(14)24(16)10-3-2-4-22-7-10/h6,9-11,22H,2-5,7-8H2,1H3,(H2,21,25)
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n/an/a 42n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261808
PNG
(CHEMBL4104355)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@H]3CCCNC3)c2n1 |r|
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)/t9-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 in human KG1 cells assessed as reduction in BAD phosphorylation

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261824
PNG
(CHEMBL4085846)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CC3CCCN3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-4-8(12(17)21)19-13-9(7)10(15)11(16)20(13)5-6-2-1-3-18-6/h4,6,18H,1-3,5H2,(H2,17,21)
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n/an/a 45n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261826
PNG
(CHEMBL4084988)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-4-8(12(17)21)19-13-9(7)10(15)11(16)20(13)6-2-1-3-18-5-6/h4,6,18H,1-3,5H2,(H2,17,21)
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n/an/a 47n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 in human KG1 cells assessed as reduction in BAD phosphorylation

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261805
PNG
(CHEMBL4096630)
Show SMILES COC\C=C\c1c(Cl)c2c(Cl)cc(nc2n1C1CCCNC1)C(N)=O
Show InChI InChI=1S/C17H20Cl2N4O2/c1-25-7-3-5-13-15(19)14-11(18)8-12(16(20)24)22-17(14)23(13)10-4-2-6-21-9-10/h3,5,8,10,21H,2,4,6-7,9H2,1H3,(H2,20,24)/b5-3+
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n/an/a 57n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261861
PNG
(CHEMBL4089255)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCNC(=O)C3)c2n1
Show InChI InChI=1S/C13H11Cl2IN4O2/c14-6-4-7(12(17)22)19-13-9(6)10(15)11(16)20(13)5-1-2-18-8(21)3-5/h4-5H,1-3H2,(H2,17,22)(H,18,21)
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n/an/a 64n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261806
PNG
(CHEMBL4078609)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(n(C3CCCNC3)c2n1)C(F)(F)F
Show InChI InChI=1S/C14H13Cl2F3N4O/c15-7-4-8(12(20)24)22-13-9(7)10(16)11(14(17,18)19)23(13)6-2-1-3-21-5-6/h4,6,21H,1-3,5H2,(H2,20,24)
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n/an/a 67n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261863
PNG
(CHEMBL4061455)
Show SMILES Cn1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O
Show InChI InChI=1S/C9H6Cl2IN3O/c1-15-7(12)6(11)5-3(10)2-4(8(13)16)14-9(5)15/h2H,1H3,(H2,13,16)
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n/an/a 69n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261864
PNG
(CHEMBL4100435)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CC3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C18H18Cl2N4O/c19-12-8-13(17(21)25)23-18-15(12)16(20)14(6-5-10-3-4-10)24(18)11-2-1-7-22-9-11/h8,10-11,22H,1-4,7,9H2,(H2,21,25)
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n/an/a 75n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 in human KG1 cells assessed as reduction in BAD phosphorylation

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261832
PNG
(CHEMBL4086532)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCC(O)C3)c2n1
Show InChI InChI=1S/C14H14Cl2IN3O2/c15-8-5-9(13(18)22)19-14-10(8)11(16)12(17)20(14)6-2-1-3-7(21)4-6/h5-7,21H,1-4H2,(H2,18,22)
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n/an/a 89n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261830
PNG
(CHEMBL4105379)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CN4CCC3CC4)c2n1 |(33.51,-30.79,;33.51,-29.25,;32.17,-28.49,;34.84,-28.49,;34.84,-26.94,;36.17,-26.17,;36.17,-24.63,;37.5,-26.94,;38.97,-26.45,;39.44,-24.98,;39.89,-27.69,;41.43,-27.68,;38.98,-28.95,;39.47,-30.41,;40.98,-30.71,;41.46,-32.18,;40.43,-33.33,;38.92,-33.01,;38.44,-31.55,;39.86,-31.35,;39.72,-32.56,;37.51,-28.48,;36.18,-29.26,)|
Show InChI InChI=1S/C15H15Cl2IN4O/c16-8-5-9(14(19)23)20-15-11(8)12(17)13(18)22(15)10-6-21-3-1-7(10)2-4-21/h5,7,10H,1-4,6H2,(H2,19,23)
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n/an/a 99n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261823
PNG
(CHEMBL4072887)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CC3CCNCC3)c2n1
Show InChI InChI=1S/C14H15Cl2IN4O/c15-8-5-9(13(18)22)20-14-10(8)11(16)12(17)21(14)6-7-1-3-19-4-2-7/h5,7,19H,1-4,6H2,(H2,18,22)
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n/an/a 99n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261860
PNG
(CHEMBL4101554)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3=CCOCC3)n(C3CCCNC3)c2n1 |t:11|
Show InChI InChI=1S/C18H20Cl2N4O2/c19-12-8-13(17(21)25)23-18-14(12)15(20)16(10-3-6-26-7-4-10)24(18)11-2-1-5-22-9-11/h3,8,11,22H,1-2,4-7,9H2,(H2,21,25)
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n/an/a 103n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261855
PNG
(CHEMBL4092706)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(-c3ccccc3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C19H18Cl2N4O/c20-13-9-14(18(22)26)24-19-15(13)16(21)17(11-5-2-1-3-6-11)25(19)12-7-4-8-23-10-12/h1-3,5-6,9,12,23H,4,7-8,10H2,(H2,22,26)
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n/an/a 109n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261857
PNG
(CHEMBL4082422)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 in human KG1 cells assessed as reduction in BAD phosphorylation

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261831
PNG
(CHEMBL4065094)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCC(O)CC3)c2n1 |(47.27,-30.19,;47.27,-28.65,;45.94,-27.88,;48.61,-27.88,;48.61,-26.34,;49.94,-25.57,;49.93,-24.03,;51.27,-26.33,;52.74,-25.85,;53.2,-24.38,;53.65,-27.09,;55.19,-27.08,;52.75,-28.34,;53.24,-29.8,;52.21,-30.94,;52.69,-32.4,;54.19,-32.72,;54.67,-34.18,;55.22,-31.57,;54.74,-30.1,;51.28,-27.87,;49.94,-28.65,)|
Show InChI InChI=1S/C14H14Cl2IN3O2/c15-8-5-9(13(18)22)19-14-10(8)11(16)12(17)20(14)6-1-3-7(21)4-2-6/h5-7,21H,1-4H2,(H2,18,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261853
PNG
(CHEMBL4102030)
Show SMILES CCN(CC)CCn1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O
Show InChI InChI=1S/C14H17Cl2IN4O/c1-3-20(4-2)5-6-21-12(17)11(16)10-8(15)7-9(13(18)22)19-14(10)21/h7H,3-6H2,1-2H3,(H2,18,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis H37RV InhA

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261865
PNG
(CHEMBL4073332)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CCCO3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C17H20Cl2N4O2/c18-10-7-11(16(20)24)22-17-13(10)14(19)15(12-4-2-6-25-12)23(17)9-3-1-5-21-8-9/h7,9,12,21H,1-6,8H2,(H2,20,24)
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n/an/a 135n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261874
PNG
(CHEMBL4064302)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CCC3CCNCC3)c2n1
Show InChI InChI=1S/C15H17Cl2IN4O/c16-9-7-10(14(19)23)21-15-11(9)12(17)13(18)22(15)6-3-8-1-4-20-5-2-8/h7-8,20H,1-6H2,(H2,19,23)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261860
PNG
(CHEMBL4101554)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3=CCOCC3)n(C3CCCNC3)c2n1 |t:11|
Show InChI InChI=1S/C18H20Cl2N4O2/c19-12-8-13(17(21)25)23-18-14(12)15(20)16(10-3-6-26-7-4-10)24(18)11-2-1-5-22-9-11/h3,8,11,22H,1-2,4-7,9H2,(H2,21,25)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261833
PNG
(CHEMBL4078687)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CNC3)c2n1
Show InChI InChI=1S/C11H9Cl2IN4O/c12-5-1-6(10(15)19)17-11-7(5)8(13)9(14)18(11)4-2-16-3-4/h1,4,16H,2-3H2,(H2,15,19)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261809
PNG
(CHEMBL4098659)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cc2c(Cl)cc(nc2n1C)C(N)=O
Show InChI InChI=1S/C20H22ClN5O/c1-24-7-9-26(10-8-24)14-5-3-13(4-6-14)18-11-15-16(21)12-17(19(22)27)23-20(15)25(18)2/h3-6,11-12H,7-10H2,1-2H3,(H2,22,27)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261859
PNG
(CHEMBL4090269)
Show SMILES COCC1CC1c1c(Cl)c2c(Cl)cc(nc2n1C1CCCNC1)C(N)=O
Show InChI InChI=1S/C18H22Cl2N4O2/c1-26-8-9-5-11(9)16-15(20)14-12(19)6-13(17(21)25)23-18(14)24(16)10-3-2-4-22-7-10/h6,9-11,22H,2-5,7-8H2,1H3,(H2,21,25)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261833
PNG
(CHEMBL4078687)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CNC3)c2n1
Show InChI InChI=1S/C11H9Cl2IN4O/c12-5-1-6(10(15)19)17-11-7(5)8(13)9(14)18(11)4-2-16-3-4/h1,4,16H,2-3H2,(H2,15,19)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261824
PNG
(CHEMBL4085846)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CC3CCCN3)c2n1
Show InChI InChI=1S/C13H13Cl2IN4O/c14-7-4-8(12(17)21)19-13-9(7)10(15)11(16)20(13)5-6-2-1-3-18-6/h4,6,18H,1-3,5H2,(H2,17,21)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261853
PNG
(CHEMBL4102030)
Show SMILES CCN(CC)CCn1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O
Show InChI InChI=1S/C14H17Cl2IN4O/c1-3-20(4-2)5-6-21-12(17)11(16)10-8(15)7-9(13(18)22)19-14(10)21/h7H,3-6H2,1-2H3,(H2,18,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261863
PNG
(CHEMBL4061455)
Show SMILES Cn1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O
Show InChI InChI=1S/C9H6Cl2IN3O/c1-15-7(12)6(11)5-3(10)2-4(8(13)16)14-9(5)15/h2H,1H3,(H2,13,16)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261861
PNG
(CHEMBL4089255)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCNC(=O)C3)c2n1
Show InChI InChI=1S/C13H11Cl2IN4O2/c14-6-4-7(12(17)22)19-13-9(6)10(15)11(16)20(13)5-1-2-18-8(21)3-5/h4-5H,1-3H2,(H2,17,22)(H,18,21)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50261862
PNG
(CHEMBL4102316)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(Cc3ccncc3)c2n1
Show InChI InChI=1S/C14H9Cl2IN4O/c15-8-5-9(13(18)22)20-14-10(8)11(16)12(17)21(14)6-7-1-3-19-4-2-7/h1-5H,6H2,(H2,18,22)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50261864
PNG
(CHEMBL4100435)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CC3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C18H18Cl2N4O/c19-12-8-13(17(21)25)23-18-15(12)16(20)14(6-5-10-3-4-10)24(18)11-2-1-7-22-9-11/h8,10-11,22H,1-4,7,9H2,(H2,21,25)
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n/an/a 1.00E+3n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis H37RV InhA

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50261807
PNG
(CHEMBL4086461)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@@H]3CCCNC3)c2n1 |r|
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)/t9-/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261875
PNG
(CHEMBL4083330)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1c(C)c2c(Cl)cc(nc2n1C)C(N)=O
Show InChI InChI=1S/C21H24ClN5O/c1-13-18-16(22)12-17(20(23)28)24-21(18)26(3)19(13)14-4-6-15(7-5-14)27-10-8-25(2)9-11-27/h4-7,12H,8-11H2,1-3H3,(H2,23,28)
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IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50261808
PNG
(CHEMBL4104355)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@H]3CCCNC3)c2n1 |r|
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)/t9-/m0/s1
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n/an/a 2.90E+3n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50261857
PNG
(CHEMBL4082422)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n(C3CCCNC3)c2n1
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)
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n/an/a 2.90E+3n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of human ERG by patch clamp assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261833
PNG
(CHEMBL4078687)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CNC3)c2n1
Show InChI InChI=1S/C11H9Cl2IN4O/c12-5-1-6(10(15)19)17-11-7(5)8(13)9(14)18(11)4-2-16-3-4/h1,4,16H,2-3H2,(H2,15,19)
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n/an/a 4.22E+3n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM50261862
PNG
(CHEMBL4102316)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(I)n(Cc3ccncc3)c2n1
Show InChI InChI=1S/C14H9Cl2IN4O/c15-8-5-9(13(18)22)20-14-10(8)11(16)12(17)21(14)6-7-1-3-19-4-2-7/h1-5H,6H2,(H2,18,22)
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n/an/a 5.62E+3n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261853
PNG
(CHEMBL4102030)
Show SMILES CCN(CC)CCn1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O
Show InChI InChI=1S/C14H17Cl2IN4O/c1-3-20(4-2)5-6-21-12(17)11(16)10-8(15)7-9(13(18)22)19-14(10)21/h7H,3-6H2,1-2H3,(H2,18,22)
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n/an/a 7.41E+3n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))		BDBM50261808
PNG
(CHEMBL4104355)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@H]3CCCNC3)c2n1 |r|
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)/t9-/m0/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4 (unknown origin) using midazolam as substrate

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))		BDBM50261807
PNG
(CHEMBL4086461)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@@H]3CCCNC3)c2n1 |r|
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)/t9-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis H37RV InhA

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))		BDBM50261808
PNG
(CHEMBL4104355)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@H]3CCCNC3)c2n1 |r|
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)/t9-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4 (unknown origin) using midazolam as substrate

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))		BDBM50261807
PNG
(CHEMBL4086461)
Show SMILES NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@@H]3CCCNC3)c2n1 |r|
Show InChI InChI=1S/C16H18Cl2N4O/c17-10-6-11(15(19)23)21-16-12(10)13(18)14(8-3-4-8)22(16)9-2-1-5-20-7-9/h6,8-9,20H,1-5,7H2,(H2,19,23)/t9-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis H37RV InhA

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM50261809
PNG
(CHEMBL4098659)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cc2c(Cl)cc(nc2n1C)C(N)=O
Show InChI InChI=1S/C20H22ClN5O/c1-24-7-9-26(10-8-24)14-5-3-13(4-6-14)18-11-15-16(21)12-17(19(22)27)23-20(15)25(18)2/h3-6,11-12H,7-10H2,1-2H3,(H2,22,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham, MA 02451, USA. Electronic address: claude.barberis2@sanofi.com.

Curated by ChEMBL


Assay Description
Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay

Bioorg Med Chem Lett 27: 4735-4740 (2017)


Article DOI: 10.1016/j.bmcl.2017.08.068
BindingDB Entry DOI: 10.7270/Q2NG4T34
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%