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PubMed code 7636873

Compile data set for download or QSAR
Found 62 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032599
PNG
((4-Methoxy-naphthalen-1-yl)-[1-(2-morpholin-4-yl-e...)
Show SMILES COc1ccc(C(=O)c2cn(CCN3CCOCC3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H26N2O3/c1-30-25-11-10-22(19-6-2-3-8-21(19)25)26(29)23-18-28(24-9-5-4-7-20(23)24)13-12-27-14-16-31-17-15-27/h2-11,18H,12-17H2,1H3
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n/an/a 1.40n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032565
PNG
((4-Methyl-naphthalen-1-yl)-[1-(2-morpholin-4-yl-et...)
Show SMILES Cc1ccc(C(=O)c2cn(CCN3CCOCC3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H26N2O2/c1-19-10-11-23(21-7-3-2-6-20(19)21)26(29)24-18-28(25-9-5-4-8-22(24)25)13-12-27-14-16-30-17-15-27/h2-11,18H,12-17H2,1H3
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n/an/a 2.80n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032584
PNG
((4-Hydroxy-naphthalen-1-yl)-[1-(2-morpholin-4-yl-e...)
Show SMILES Oc1ccc(C(=O)c2cn(CCN3CCOCC3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24N2O3/c28-24-10-9-21(18-5-1-2-7-20(18)24)25(29)22-17-27(23-8-4-3-6-19(22)23)12-11-26-13-15-30-16-14-26/h1-10,17,28H,11-16H2
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n/an/a 3.40n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032615
PNG
(CHEMBL82361 | [6-Methyl-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Cc1ccc2c(cn(CCN3CCOCC3)c2c1)C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C26H26N2O2/c1-19-9-10-22-24(26(29)23-8-4-6-20-5-2-3-7-21(20)23)18-28(25(22)17-19)12-11-27-13-15-30-16-14-27/h2-10,17-18H,11-16H2,1H3
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n/an/a 3.5n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM60994
PNG
((10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tet...)
Show SMILES CCCCCc1cc(O)c2[C@@H]3C=C(C)CC[C@H]3C(C)(C)Oc2c1 |r,t:11|
Show InChI InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1
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n/an/a 5.80n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032575
PNG
(CHEMBL309763 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Show SMILES Cc1c(C(=O)c2ccc(C)c3ccccc23)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C27H28N2O2/c1-19-11-12-23(22-8-4-3-7-21(19)22)27(30)26-20(2)29(25-10-6-5-9-24(25)26)14-13-28-15-17-31-18-16-28/h3-12H,13-18H2,1-2H3
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n/an/a 5.90n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032583
PNG
((4-Bromo-naphthalen-1-yl)-[2-methyl-1-(2-morpholin...)
Show SMILES Cc1c(C(=O)c2ccc(Br)c3ccccc23)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C26H25BrN2O2/c1-18-25(26(30)21-10-11-23(27)20-7-3-2-6-19(20)21)22-8-4-5-9-24(22)29(18)13-12-28-14-16-31-17-15-28/h2-11H,12-17H2,1H3
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n/an/a 6.90n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50009854
PNG
(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1cccc2ccccc12
Show InChI InChI=1S/C25H24N2O2/c28-25(22-10-5-7-19-6-1-2-8-20(19)22)23-18-27(24-11-4-3-9-21(23)24)13-12-26-14-16-29-17-15-26/h1-11,18H,12-17H2
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n/an/a 7.80n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032589
PNG
(CHEMBL78415 | [7-Methoxy-2-methyl-1-(2-morpholin-4...)
Show SMILES COc1cccc2c(C(=O)c3cccc4ccccc34)c(C)n(CCN3CCOCC3)c12
Show InChI InChI=1S/C27H28N2O3/c1-19-25(27(30)22-10-5-8-20-7-3-4-9-21(20)22)23-11-6-12-24(31-2)26(23)29(19)14-13-28-15-17-32-18-16-28/h3-12H,13-18H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032616
PNG
(CHEMBL78940 | [6-Bromo-2-methyl-1-(2-morpholin-4-y...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2ccc(Br)cc2n1CCN1CCOCC1
Show InChI InChI=1S/C26H25BrN2O2/c1-18-25(26(30)22-8-4-6-19-5-2-3-7-21(19)22)23-10-9-20(27)17-24(23)29(18)12-11-28-13-15-31-16-14-28/h2-10,17H,11-16H2,1H3
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n/an/a 10n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032621
PNG
(CHEMBL78713 | [2-Chloro-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Clc1c(C(=O)c2cccc3ccccc23)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C25H23ClN2O2/c26-25-23(24(29)20-10-5-7-18-6-1-2-8-19(18)20)21-9-3-4-11-22(21)28(25)13-12-27-14-16-30-17-15-27/h1-11H,12-17H2
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n/an/a 10n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032560
PNG
(CHEMBL78994 | [2,6-Dimethyl-1-(2-morpholin-4-yl-et...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2ccc(C)cc2n1CCN1CCOCC1
Show InChI InChI=1S/C27H28N2O2/c1-19-10-11-24-25(18-19)29(13-12-28-14-16-31-17-15-28)20(2)26(24)27(30)23-9-5-7-21-6-3-4-8-22(21)23/h3-11,18H,12-17H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032561
PNG
(CHEMBL104841 | [2-Methyl-1-(1-methyl-2-morpholin-4...)
Show SMILES CC(CN1CCOCC1)n1c(C)c(C(=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H28N2O2/c1-19(18-28-14-16-31-17-15-28)29-20(2)26(24-11-5-6-13-25(24)29)27(30)23-12-7-9-21-8-3-4-10-22(21)23/h3-13,19H,14-18H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032555
PNG
(4-[2-Methyl-1-(2-morpholin-4-yl-ethyl)-1H-indole-3...)
Show SMILES Cc1c(C(=O)c2ccc(C#N)c3ccccc23)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C27H25N3O2/c1-19-26(27(31)23-11-10-20(18-28)21-6-2-3-7-22(21)23)24-8-4-5-9-25(24)30(19)13-12-29-14-16-32-17-15-29/h2-11H,12-17H2,1H3
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n/an/a 15n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032567
PNG
(Benzofuran-7-yl-[1-(2-morpholin-4-yl-ethyl)-1H-ind...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1cccc2ccoc12
Show InChI InChI=1S/C23H22N2O3/c26-22(19-6-3-4-17-8-13-28-23(17)19)20-16-25(21-7-2-1-5-18(20)21)10-9-24-11-14-27-15-12-24/h1-8,13,16H,9-12,14-15H2
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n/an/a 18n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50009864
PNG
(CHEMBL274833 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C26H26N2O2/c1-19-25(26(29)22-11-6-8-20-7-2-3-9-21(20)22)23-10-4-5-12-24(23)28(19)14-13-27-15-17-30-18-16-27/h2-12H,13-18H2,1H3
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n/an/a 19n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032562
PNG
(Benzofuran-4-yl-[1-(2-morpholin-4-yl-ethyl)-1H-ind...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1cccc2occc12
Show InChI InChI=1S/C23H22N2O3/c26-23(19-5-3-7-22-18(19)8-13-28-22)20-16-25(21-6-2-1-4-17(20)21)10-9-24-11-14-27-15-12-24/h1-8,13,16H,9-12,14-15H2
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n/an/a 24n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032595
PNG
(CHEMBL107106 | [1-(1-Methyl-2-morpholin-4-yl-ethyl...)
Show SMILES CC(CN1CCOCC1)n1cc(C(=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H26N2O2/c1-19(17-27-13-15-30-16-14-27)28-18-24(22-10-4-5-12-25(22)28)26(29)23-11-6-8-20-7-2-3-9-21(20)23/h2-12,18-19H,13-17H2,1H3
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n/an/a 33n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032595
PNG
(CHEMBL107106 | [1-(1-Methyl-2-morpholin-4-yl-ethyl...)
Show SMILES CC(CN1CCOCC1)n1cc(C(=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H26N2O2/c1-19(17-27-13-15-30-16-14-27)28-18-24(22-10-4-5-12-25(22)28)26(29)23-11-6-8-20-7-2-3-9-21(20)23/h2-12,18-19H,13-17H2,1H3
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n/an/a 33n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032613
PNG
(CHEMBL78308 | [5-Fluoro-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Fc1ccc2n(CCN3CCOCC3)cc(C(=O)c3cccc4ccccc34)c2c1
Show InChI InChI=1S/C25H23FN2O2/c26-19-8-9-24-22(16-19)23(17-28(24)11-10-27-12-14-30-15-13-27)25(29)21-7-3-5-18-4-1-2-6-20(18)21/h1-9,16-17H,10-15H2
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n/an/a 35n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032596
PNG
(CHEMBL311645 | [2-Methyl-1-(2-piperidin-1-yl-ethyl...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2ccccc2n1CCN1CCCCC1
Show InChI InChI=1S/C27H28N2O/c1-20-26(27(30)23-14-9-11-21-10-3-4-12-22(21)23)24-13-5-6-15-25(24)29(20)19-18-28-16-7-2-8-17-28/h3-6,9-15H,2,7-8,16-19H2,1H3
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n/an/a 37n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032629
PNG
(CHEMBL311560 | [1-(2-Morpholin-4-yl-ethyl)-1H-indo...)
Show SMILES O=C(C1CCCc2ccccc12)c1cn(CCN2CCOCC2)c2ccccc12
Show InChI InChI=1S/C25H28N2O2/c28-25(22-10-5-7-19-6-1-2-8-20(19)22)23-18-27(24-11-4-3-9-21(23)24)13-12-26-14-16-29-17-15-26/h1-4,6,8-9,11,18,22H,5,7,10,12-17H2
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n/an/a 38n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032604
PNG
(CHEMBL323501 | [1-(3-Morpholin-4-yl-propyl)-1H-ind...)
Show SMILES O=C(c1cn(CCCN2CCOCC2)c2ccccc12)c1cccc2ccccc12
Show InChI InChI=1S/C26H26N2O2/c29-26(23-11-5-8-20-7-1-2-9-21(20)23)24-19-28(25-12-4-3-10-22(24)25)14-6-13-27-15-17-30-18-16-27/h1-5,7-12,19H,6,13-18H2
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n/an/a 43n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032582
PNG
((4-Methoxy-naphthalen-1-yl)-[2-methyl-1-(2-morphol...)
Show SMILES COc1ccc(C(=O)c2c(C)n(CCN3CCOCC3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H28N2O3/c1-19-26(27(30)22-11-12-25(31-2)21-8-4-3-7-20(21)22)23-9-5-6-10-24(23)29(19)14-13-28-15-17-32-18-16-28/h3-12H,13-18H2,1-2H3
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n/an/a 55n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032544
PNG
(CHEMBL79204 | {2-Methyl-1-[2-(2-methyl-morpholin-4...)
Show SMILES CC1CN(CCn2c(C)c(C(=O)c3cccc4ccccc34)c3ccccc23)CCO1
Show InChI InChI=1S/C27H28N2O2/c1-19-18-28(16-17-31-19)14-15-29-20(2)26(24-11-5-6-13-25(24)29)27(30)23-12-7-9-21-8-3-4-10-22(21)23/h3-13,19H,14-18H2,1-2H3
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n/an/a 59n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032622
PNG
(CHEMBL307073 | [1-(2-Morpholin-4-yl-ethyl)-1H-indo...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H24N2O2/c28-25(21-10-9-19-5-1-2-6-20(19)17-21)23-18-27(24-8-4-3-7-22(23)24)12-11-26-13-15-29-16-14-26/h1-10,17-18H,11-16H2
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n/an/a 59n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032568
PNG
(CHEMBL78627 | [5-Hydroxy-1-(2-morpholin-4-yl-ethyl...)
Show SMILES Oc1ccc2n(CCN3CCOCC3)cc(C(=O)c3cccc4ccccc34)c2c1
Show InChI InChI=1S/C25H24N2O3/c28-19-8-9-24-22(16-19)23(17-27(24)11-10-26-12-14-30-15-13-26)25(29)21-7-3-5-18-4-1-2-6-20(18)21/h1-9,16-17,28H,10-15H2
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n/an/a 70n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032637
PNG
(Benzofuran-7-yl-[2-methyl-1-(2-morpholin-4-yl-ethy...)
Show SMILES Cc1c(C(=O)c2cccc3ccoc23)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C24H24N2O3/c1-17-22(23(27)20-7-4-5-18-9-14-29-24(18)20)19-6-2-3-8-21(19)26(17)11-10-25-12-15-28-16-13-25/h2-9,14H,10-13,15-16H2,1H3
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n/an/a 71n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032594
PNG
(Benzofuran-3-yl-[2-methyl-1-(2-morpholin-4-yl-ethy...)
Show SMILES Cc1c(C(=O)c2coc3ccccc23)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C24H24N2O3/c1-17-23(24(27)20-16-29-22-9-5-3-6-18(20)22)19-7-2-4-8-21(19)26(17)11-10-25-12-14-28-15-13-25/h2-9,16H,10-15H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032542
PNG
(CHEMBL319464 | [1-(2-Morpholin-4-yl-propyl)-1H-ind...)
Show SMILES CC(Cn1cc(C(=O)c2cccc3ccccc23)c2ccccc12)N1CCOCC1
Show InChI InChI=1S/C26H26N2O2/c1-19(27-13-15-30-16-14-27)17-28-18-24(22-10-4-5-12-25(22)28)26(29)23-11-6-8-20-7-2-3-9-21(20)23/h2-12,18-19H,13-17H2,1H3
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n/an/a 124n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032603
PNG
(CHEMBL78763 | [2-Methyl-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Cc1c(C(=O)c2ccc3ccccc3c2)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C26H26N2O2/c1-19-25(26(29)22-11-10-20-6-2-3-7-21(20)18-22)23-8-4-5-9-24(23)28(19)13-12-27-14-16-30-17-15-27/h2-11,18H,12-17H2,1H3
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n/an/a 128n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032556
PNG
(Benzofuran-5-yl-[1-(2-morpholin-4-yl-ethyl)-1H-ind...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1ccc2occc2c1
Show InChI InChI=1S/C23H22N2O3/c26-23(18-5-6-22-17(15-18)7-12-28-22)20-16-25(21-4-2-1-3-19(20)21)9-8-24-10-13-27-14-11-24/h1-7,12,15-16H,8-11,13-14H2
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n/an/a 138n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032548
PNG
((3,4-Dimethyl-phenyl)-[2-methyl-1-(2-morpholin-4-y...)
Show SMILES Cc1c(C(=O)c2ccc(C)c(C)c2)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C24H28N2O2/c1-17-8-9-20(16-18(17)2)24(27)23-19(3)26(22-7-5-4-6-21(22)23)11-10-25-12-14-28-15-13-25/h4-9,16H,10-15H2,1-3H3
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n/an/a 140n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032558
PNG
(CHEMBL431862 | [2-Methyl-1-(3-morpholin-4-yl-propy...)
Show SMILES Cc1c(C(=O)c2cccc3ccccc23)c2ccccc2n1CCCN1CCOCC1
Show InChI InChI=1S/C27H28N2O2/c1-20-26(27(30)23-12-6-9-21-8-2-3-10-22(21)23)24-11-4-5-13-25(24)29(20)15-7-14-28-16-18-31-19-17-28/h2-6,8-13H,7,14-19H2,1H3
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n/an/a 150n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032579
PNG
(CHEMBL310995 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Show SMILES Cc1c(C(=O)c2ccc3cccnc3c2)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C25H25N3O2/c1-18-24(25(29)20-9-8-19-5-4-10-26-22(19)17-20)21-6-2-3-7-23(21)28(18)12-11-27-13-15-30-16-14-27/h2-10,17H,11-16H2,1H3
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n/an/a 177n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032570
PNG
(CHEMBL311328 | [5-Bromo-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Brc1ccc2n(CCN3CCOCC3)cc(C(=O)c3cccc4ccccc34)c2c1
Show InChI InChI=1S/C25H23BrN2O2/c26-19-8-9-24-22(16-19)23(17-28(24)11-10-27-12-14-30-15-13-27)25(29)21-7-3-5-18-4-1-2-6-20(18)21/h1-9,16-17H,10-15H2
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n/an/a 186n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032597
PNG
(CHEMBL80938 | [2-Methyl-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Cc1c(C(=O)c2cccc3cccnc23)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C25H25N3O2/c1-18-23(25(29)21-9-4-6-19-7-5-11-26-24(19)21)20-8-2-3-10-22(20)28(18)13-12-27-14-16-30-17-15-27/h2-11H,12-17H2,1H3
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n/an/a 274n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032564
PNG
(CHEMBL77445 | [2-Methyl-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Cc1c(C(=O)c2ccnc3ccccc23)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C25H25N3O2/c1-18-24(25(29)20-10-11-26-22-8-4-2-6-19(20)22)21-7-3-5-9-23(21)28(18)13-12-27-14-16-30-17-15-27/h2-11H,12-17H2,1H3
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n/an/a 283n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032610
PNG
(Benzofuran-6-yl-[1-(2-morpholin-4-yl-ethyl)-1H-ind...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1ccc2ccoc2c1
Show InChI InChI=1S/C23H22N2O3/c26-23(18-6-5-17-7-12-28-22(17)15-18)20-16-25(21-4-2-1-3-19(20)21)9-8-24-10-13-27-14-11-24/h1-7,12,15-16H,8-11,13-14H2
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n/an/a 304n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032606
PNG
((4-Ethyl-phenyl)-[2-methyl-1-(2-morpholin-4-yl-eth...)
Show SMILES CCc1ccc(cc1)C(=O)c1c(C)n(CCN2CCOCC2)c2ccccc12
Show InChI InChI=1S/C24H28N2O2/c1-3-19-8-10-20(11-9-19)24(27)23-18(2)26(22-7-5-4-6-21(22)23)13-12-25-14-16-28-17-15-25/h4-11H,3,12-17H2,1-2H3
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n/an/a 306n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032549
PNG
(CHEMBL311065 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Show SMILES Cc1c(C(=O)c2ccc3ccccc3n2)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C25H25N3O2/c1-18-24(25(29)22-11-10-19-6-2-4-8-21(19)26-22)20-7-3-5-9-23(20)28(18)13-12-27-14-16-30-17-15-27/h2-11H,12-17H2,1H3
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n/an/a 331n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032580
PNG
(Benzofuran-5-yl-[2-methyl-1-(2-morpholin-4-yl-ethy...)
Show SMILES Cc1c(C(=O)c2ccc3occc3c2)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C24H24N2O3/c1-17-23(24(27)19-6-7-22-18(16-19)8-13-29-22)20-4-2-3-5-21(20)26(17)10-9-25-11-14-28-15-12-25/h2-8,13,16H,9-12,14-15H2,1H3
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n/an/a 357n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032581
PNG
((2,3-Dimethyl-phenyl)-[2-methyl-1-(2-morpholin-4-y...)
Show SMILES Cc1c(C(=O)c2cccc(C)c2C)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C24H28N2O2/c1-17-7-6-9-20(18(17)2)24(27)23-19(3)26(22-10-5-4-8-21(22)23)12-11-25-13-15-28-16-14-25/h4-10H,11-16H2,1-3H3
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n/an/a 373n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032545
PNG
(CHEMBL80984 | {2-Methyl-1-[2-(3-methyl-morpholin-4...)
Show SMILES CC1COCCN1CCn1c(C)c(C(=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H28N2O2/c1-19-18-31-17-16-28(19)14-15-29-20(2)26(24-11-5-6-13-25(24)29)27(30)23-12-7-9-21-8-3-4-10-22(21)23/h3-13,19H,14-18H2,1-2H3
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n/an/a 384n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50009868
PNG
((4-Methoxy-phenyl)-[1-(2-morpholin-4-yl-ethyl)-1H-...)
Show SMILES COc1ccc(cc1)C(=O)c1cn(CCN2CCOCC2)c2ccccc12
Show InChI InChI=1S/C22H24N2O3/c1-26-18-8-6-17(7-9-18)22(25)20-16-24(21-5-3-2-4-19(20)21)11-10-23-12-14-27-15-13-23/h2-9,16H,10-15H2,1H3
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n/an/a 390n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032551
PNG
(Benzofuran-2-yl-[2-methyl-1-(2-morpholin-4-yl-ethy...)
Show SMILES Cc1c(C(=O)c2cc3ccccc3o2)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C24H24N2O3/c1-17-23(24(27)22-16-18-6-2-5-9-21(18)29-22)19-7-3-4-8-20(19)26(17)11-10-25-12-14-28-15-13-25/h2-9,16H,10-15H2,1H3
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n/an/a 416n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032618
PNG
(CHEMBL78992 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1ccc2ncccc2c1
Show InChI InChI=1S/C24H23N3O2/c28-24(19-7-8-22-18(16-19)4-3-9-25-22)21-17-27(23-6-2-1-5-20(21)23)11-10-26-12-14-29-15-13-26/h1-9,16-17H,10-15H2
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n/an/a 491n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032619
PNG
(CHEMBL309700 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Show SMILES Cc1c(C(=O)c2ccc3ncccc3c2)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C25H25N3O2/c1-18-24(25(29)20-8-9-22-19(17-20)5-4-10-26-22)21-6-2-3-7-23(21)28(18)12-11-27-13-15-30-16-14-27/h2-10,17H,11-16H2,1H3
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n/an/a 499n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032586
PNG
(CHEMBL310741 | [6-Bromo-2-methyl-1-(2-morpholin-4-...)
Show SMILES COc1ccc(cc1)C(=O)c1c(C)n(CCN2CCOCC2)c2cc(Br)ccc12
Show InChI InChI=1S/C23H25BrN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3
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n/an/a 515n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032546
PNG
(CHEMBL78701 | [7-Fluoro-2-methyl-1-(2-morpholin-4-...)
Show SMILES COc1ccc(cc1)C(=O)c1c(C)n(CCN2CCOCC2)c2c(F)cccc12
Show InChI InChI=1S/C23H25FN2O3/c1-16-21(23(27)17-6-8-18(28-2)9-7-17)19-4-3-5-20(24)22(19)26(16)11-10-25-12-14-29-15-13-25/h3-9H,10-15H2,1-2H3
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n/an/a 571n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032553
PNG
(CHEMBL12914 | [2-Methyl-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Cc1c(C(=O)c2cccc(C)c2)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C23H26N2O2/c1-17-6-5-7-19(16-17)23(26)22-18(2)25(21-9-4-3-8-20(21)22)11-10-24-12-14-27-15-13-24/h3-9,16H,10-15H2,1-2H3
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n/an/a 606n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032572
PNG
((4-Methoxy-phenyl)-[2-methyl-1-(2-thiomorpholin-4-...)
Show SMILES COc1ccc(cc1)C(=O)c1c(C)n(CCN2CCSCC2)c2ccccc12
Show InChI InChI=1S/C23H26N2O2S/c1-17-22(23(26)18-7-9-19(27-2)10-8-18)20-5-3-4-6-21(20)25(17)12-11-24-13-15-28-16-14-24/h3-10H,11-16H2,1-2H3
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n/an/a 622n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032576
PNG
((2-Methoxy-phenyl)-[2-methyl-1-(2-morpholin-4-yl-e...)
Show SMILES COc1ccccc1C(=O)c1c(C)n(CCN2CCOCC2)c2ccccc12
Show InChI InChI=1S/C23H26N2O3/c1-17-22(23(26)19-8-4-6-10-21(19)27-2)18-7-3-5-9-20(18)25(17)12-11-24-13-15-28-16-14-24/h3-10H,11-16H2,1-2H3
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n/an/a 800n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032566
PNG
(CHEMBL78710 | [2-Methyl-1-(2-morpholin-4-yl-ethyl)...)
Show SMILES Cc1c(C(=O)c2cccc3ncccc23)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C25H25N3O2/c1-18-24(25(29)20-7-4-9-22-19(20)8-5-11-26-22)21-6-2-3-10-23(21)28(18)13-12-27-14-16-30-17-15-27/h2-11H,12-17H2,1H3
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n/an/a 828n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032598
PNG
(CHEMBL104688 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Show SMILES CCCc1ccc(cc1)C(=O)c1c(C)n(CCN2CCOCC2)c2ccccc12
Show InChI InChI=1S/C25H30N2O2/c1-3-6-20-9-11-21(12-10-20)25(28)24-19(2)27(23-8-5-4-7-22(23)24)14-13-26-15-17-29-18-16-26/h4-5,7-12H,3,6,13-18H2,1-2H3
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n/an/a 1.13E+3n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032614
PNG
((3-Chloro-phenyl)-[2-methyl-1-(2-morpholin-4-yl-et...)
Show SMILES Cc1c(C(=O)c2cccc(Cl)c2)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C22H23ClN2O2/c1-16-21(22(26)17-5-4-6-18(23)15-17)19-7-2-3-8-20(19)25(16)10-9-24-11-13-27-14-12-24/h2-8,15H,9-14H2,1H3
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n/an/a 1.32E+3n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032541
PNG
(CHEMBL310751 | [6-Methoxy-2-methyl-1-(2-morpholin-...)
Show SMILES COc1ccc(cc1)C(=O)c1c(C)n(CCN2CCOCC2)c2cc(OC)ccc12
Show InChI InChI=1S/C24H28N2O4/c1-17-23(24(27)18-4-6-19(28-2)7-5-18)21-9-8-20(29-3)16-22(21)26(17)11-10-25-12-14-30-15-13-25/h4-9,16H,10-15H2,1-3H3
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n/an/a 1.45E+3n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032591
PNG
(CHEMBL310538 | [2,7-Dimethyl-1-(2-morpholin-4-yl-e...)
Show SMILES COc1ccc(cc1)C(=O)c1c(C)n(CCN2CCOCC2)c2c(C)cccc12
Show InChI InChI=1S/C24H28N2O3/c1-17-5-4-6-21-22(24(27)19-7-9-20(28-3)10-8-19)18(2)26(23(17)21)12-11-25-13-15-29-16-14-25/h4-10H,11-16H2,1-3H3
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n/an/a 1.53E+3n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032563
PNG
(CHEMBL275242 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Show SMILES Cc1c(C(=O)c2ccc(C)cc2)c2ccccc2n1CCN1CCOCC1
Show InChI InChI=1S/C23H26N2O2/c1-17-7-9-19(10-8-17)23(26)22-18(2)25(21-6-4-3-5-20(21)22)12-11-24-13-15-27-16-14-24/h3-10H,11-16H2,1-2H3
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n/an/a 1.77E+3n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032617
PNG
(CHEMBL310539 | [2,6-Dimethyl-1-(2-morpholin-4-yl-e...)
Show SMILES COc1ccc(cc1)C(=O)c1c(C)n(CCN2CCOCC2)c2cc(C)ccc12
Show InChI InChI=1S/C24H28N2O3/c1-17-4-9-21-22(16-17)26(11-10-25-12-14-29-15-13-25)18(2)23(21)24(27)19-5-7-20(28-3)8-6-19/h4-9,16H,10-15H2,1-3H3
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n/an/a 1.88E+3n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50032571
PNG
(Anthracen-9-yl-[1-(2-morpholin-4-yl-ethyl)-1H-indo...)
Show SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C29H26N2O2/c32-29(28-23-9-3-1-7-21(23)19-22-8-2-4-10-24(22)28)26-20-31(27-12-6-5-11-25(26)27)14-13-30-15-17-33-18-16-30/h1-12,19-20H,13-18H2
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n/an/a 2.97E+3n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Rattus norvegicus (rat))		BDBM50008029
PNG
((4-Methoxy-phenyl)-[2-methyl-1-(2-morpholin-4-yl-e...)
Show SMILES COc1ccc(cc1)C(=O)c1c(C)n(CCN2CCOCC2)c2ccccc12
Show InChI InChI=1S/C23H26N2O3/c1-17-22(23(26)18-7-9-19(27-2)10-8-18)20-5-3-4-6-21(20)25(17)12-11-24-13-15-28-16-14-24/h3-10H,11-16H2,1-2H3
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n/an/a 3.16E+3n/an/an/an/an/an/a



Sanofi Research Division

Curated by ChEMBL


Assay Description
Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.

J Med Chem 38: 3094-105 (1995)


BindingDB Entry DOI: 10.7270/Q2DN442Z
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Ligand-Target Pair
* indicates data uncertainty>20%