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PubMed code 8093908

Compile data set for download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50040108
PNG
(11-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-ethylsulfa...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCN3CCc4ccccc4C3)c2c1
Show InChI InChI=1S/C26H25NO3S/c28-26(29)19-9-10-24-23(15-19)25(22-8-4-3-7-21(22)17-30-24)31-14-13-27-12-11-18-5-1-2-6-20(18)16-27/h1-10,15,25H,11-14,16-17H2,(H,28,29)
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 6.90n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50002084
PNG
(11-(2-Dimethylamino-ethylsulfanyl)-6,11-dihydro-di...)
Show SMILES CN(C)CCSC1c2ccccc2COc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C19H21NO3S/c1-20(2)9-10-24-18-15-6-4-3-5-14(15)12-23-17-8-7-13(19(21)22)11-16(17)18/h3-8,11,18H,9-10,12H2,1-2H3,(H,21,22)
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 9n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50040114
PNG
(CHEMBL336198 | {11-[2-(4-Benzyl-piperidin-1-yl)-et...)
Show SMILES OC(=O)Cc1ccc2OCc3ccccc3C(SCCN3CCC(Cc4ccccc4)CC3)c2c1
Show InChI InChI=1S/C30H33NO3S/c32-29(33)20-24-10-11-28-27(19-24)30(26-9-5-4-8-25(26)21-34-28)35-17-16-31-14-12-23(13-15-31)18-22-6-2-1-3-7-22/h1-11,19,23,30H,12-18,20-21H2,(H,32,33)
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 10n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50002088
PNG
(CHEMBL302005 | [11-(2-Dimethylamino-ethylidene)-6,...)
Show SMILES CN(C)C\C=C1/c2ccccc2COc2ccc(CC(O)=O)cc12
Show InChI InChI=1S/C20H21NO3/c1-21(2)10-9-17-16-6-4-3-5-15(16)13-24-19-8-7-14(11-18(17)19)12-20(22)23/h3-9,11H,10,12-13H2,1-2H3,(H,22,23)/b17-9+
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 11n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50040109
PNG
(3-{11-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-...)
Show SMILES OC(=O)CCc1ccc2OCc3ccccc3C(SCCN3CCC(Cc4ccccc4)CC3)c2c1
Show InChI InChI=1S/C31H35NO3S/c33-30(34)13-11-24-10-12-29-28(21-24)31(27-9-5-4-8-26(27)22-35-29)36-19-18-32-16-14-25(15-17-32)20-23-6-2-1-3-7-23/h1-10,12,21,25,31H,11,13-20,22H2,(H,33,34)
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 12n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50040112
PNG
(11-[2-(4-Benzyl-piperazin-1-yl)-ethylsulfanyl]-6,1...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCN3CCN(Cc4ccccc4)CC3)c2c1
Show InChI InChI=1S/C28H30N2O3S/c31-28(32)22-10-11-26-25(18-22)27(24-9-5-4-8-23(24)20-33-26)34-17-16-29-12-14-30(15-13-29)19-21-6-2-1-3-7-21/h1-11,18,27H,12-17,19-20H2,(H,31,32)
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 14n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50175516
PNG
(CHEMBL372588 | {11-[2-(4-Benzyl-piperidin-1-yl)-et...)
Show SMILES OC(=O)Cc1ccc2OCc3ccccc3\C(=C\CN3CCC(Cc4ccccc4)CC3)c2c1
Show InChI InChI=1S/C30H31NO3/c32-30(33)20-24-10-11-29-28(19-24)27(26-9-5-4-8-25(26)21-34-29)14-17-31-15-12-23(13-16-31)18-22-6-2-1-3-7-22/h1-11,14,19,23H,12-13,15-18,20-21H2,(H,32,33)/b27-14-
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 15n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50040110
PNG
(2-{11-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-...)
Show SMILES CC(C)(C(O)=O)c1ccc2OCc3ccccc3C(SCCN3CCC(Cc4ccccc4)CC3)c2c1
Show InChI InChI=1S/C32H37NO3S/c1-32(2,31(34)35)26-12-13-29-28(21-26)30(27-11-7-6-10-25(27)22-36-29)37-19-18-33-16-14-24(15-17-33)20-23-8-4-3-5-9-23/h3-13,21,24,30H,14-20,22H2,1-2H3,(H,34,35)
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 17n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50040111
PNG
(CHEMBL133080 | {11-[2-(4-Benzyl-piperidin-1-yl)-et...)
Show SMILES OC(=O)Cc1ccc2OCc3ccccc3\C(=C/CN3CCC(Cc4ccccc4)CC3)c2c1
Show InChI InChI=1S/C30H31NO3/c32-30(33)20-24-10-11-29-28(19-24)27(26-9-5-4-8-25(26)21-34-29)14-17-31-15-12-23(13-16-31)18-22-6-2-1-3-7-22/h1-11,14,19,23H,12-13,15-18,20-21H2,(H,32,33)/b27-14+
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 20n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50040121
PNG
(11-[2-(4-Phenyl-piperidin-1-yl)-ethylsulfanyl]-6,1...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCN3CCC(CC3)c3ccccc3)c2c1
Show InChI InChI=1S/C28H29NO3S/c30-28(31)22-10-11-26-25(18-22)27(24-9-5-4-8-23(24)19-32-26)33-17-16-29-14-12-21(13-15-29)20-6-2-1-3-7-20/h1-11,18,21,27H,12-17,19H2,(H,30,31)
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 20n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50040113
PNG
(11-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-ethylsu...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCN3CCN(CC3)c3ccc(F)cc3)c2c1
Show InChI InChI=1S/C27H27FN2O3S/c28-21-6-8-22(9-7-21)30-13-11-29(12-14-30)15-16-34-26-23-4-2-1-3-20(23)18-33-25-10-5-19(27(31)32)17-24(25)26/h1-10,17,26H,11-16,18H2,(H,31,32)
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 41n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50040116
PNG
(11-(2-Morpholin-4-yl-ethylsulfanyl)-6,11-dihydro-d...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCN3CCOCC3)c2c1
Show InChI InChI=1S/C21H23NO4S/c23-21(24)15-5-6-19-18(13-15)20(17-4-2-1-3-16(17)14-26-19)27-12-9-22-7-10-25-11-8-22/h1-6,13,20H,7-12,14H2,(H,23,24)
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 42n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50040119
PNG
(11-[2-(4-Phenyl-piperazin-1-yl)-ethylsulfanyl]-6,1...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCN3CCN(CC3)c3ccccc3)c2c1
Show InChI InChI=1S/C27H28N2O3S/c30-27(31)20-10-11-25-24(18-20)26(23-9-5-4-6-21(23)19-32-25)33-17-16-28-12-14-29(15-13-28)22-7-2-1-3-8-22/h1-11,18,26H,12-17,19H2,(H,30,31)
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 47n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50040117
PNG
(11-{2-[4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-pi...)
Show SMILES OC(=O)c1ccc2OCc3ccccc3C(SCCN3CCC(CC3)n3c4ccccc4[nH]c3=O)c2c1
Show InChI InChI=1S/C29H29N3O4S/c33-28(34)19-9-10-26-23(17-19)27(22-6-2-1-5-20(22)18-36-26)37-16-15-31-13-11-21(12-14-31)32-25-8-4-3-7-24(25)30-29(32)35/h1-10,17,21,27H,11-16,18H2,(H,30,35)(H,33,34)
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 500n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50040115
PNG
(CHEMBL133778 | Sodium; 11-[2-(4-benzyl-piperidin-1...)
Show SMILES [O-]C(=O)c1ccc2OCc3ccccc3C(SCCN3CCC(Cc4ccccc4)CC3)c2c1
Show InChI InChI=1S/C29H31NO3S/c31-29(32)23-10-11-27-26(19-23)28(25-9-5-4-8-24(25)20-33-27)34-17-16-30-14-12-22(13-15-30)18-21-6-2-1-3-7-21/h1-11,19,22,28H,12-18,20H2,(H,31,32)/p-1
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 740n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co.

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [3H]-pyrilamine to guinea pig cerebellum histamine H1 receptor

J Med Chem 36: 417-20 (1993)


BindingDB Entry DOI: 10.7270/Q2Q23Z9K
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%