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USPatent US9802960

Compile Data Set for Download or QSAR

Found 484 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338113
PNG
(US9751854, Compound I-289 | US9802960, Compound I-...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccnc(Nc2ccc(C#N)c(C)n2)c1
Show InChI InChI=1S/C24H18F2N6O2S/c1-14-17(12-27)3-6-23(30-14)31-24-10-16(7-8-28-24)18-9-21(15(2)29-13-18)32-35(33,34)22-5-4-19(25)11-20(22)26/h3-11,13,32H,1-2H3,(H,28,30,31)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM352719
PNG
(US9802960, Compound I-298)
Show SMILES Nc1ncc(cc1C(=O)NC12CC(C1)C2)-c1ccnc(Nc2ccncn2)c1
Show InChI InChI=1S/C20H19N7O/c21-18-15(19(28)27-20-7-12(8-20)9-20)5-14(10-24-18)13-1-4-23-17(6-13)26-16-2-3-22-11-25-16/h1-6,10-12H,7-9H2,(H2,21,24)(H,27,28)(H,22,23,25,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338176
PNG
(US9751854, Compound I-356 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(cc2F)C#N)c1
Show InChI InChI=1S/C20H16FN5O3S/c1-12-18(26-30(28,29)19-4-3-14(10-22)7-17(19)21)8-16(11-24-12)15-5-6-23-20(9-15)25-13(2)27/h3-9,11,26H,1-2H3,(H,23,25,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338201
PNG
(US9751854, Compound I-382 | US9802960, Compound I-...)
Show SMILES Cc1nc(Nc2cc(ccn2)-c2cnc(C)c(NS(=O)(=O)c3ccc(F)cc3F)c2)nc(n1)C1CC1
Show InChI InChI=1S/C24H21F2N7O2S/c1-13-20(33-36(34,35)21-6-5-18(25)11-19(21)26)9-17(12-28-13)16-7-8-27-22(10-16)31-24-30-14(2)29-23(32-24)15-3-4-15/h5-12,15,33H,3-4H2,1-2H3,(H,27,29,30,31,32)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338217
PNG
(US9751854, Compound I-401 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(Cl)c(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1C
Show InChI InChI=1S/C19H15Cl3N4O3S/c1-10-14(12-5-6-23-17(7-12)25-11(2)27)9-24-19(22)18(10)26-30(28,29)16-8-13(20)3-4-15(16)21/h3-9,26H,1-2H3,(H,23,25,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338269
PNG
(US9751854, Compound I-454 | US9802960, Compound I-...)
Show SMILES Cc1nccc(Nc2cc(ccn2)-c2c[n+]([O-])c(Cl)c(NS(=O)(=O)c3ccc(F)cc3F)c2C)n1
Show InChI InChI=1S/C22H17ClF2N6O3S/c1-12-16(14-5-7-27-20(9-14)29-19-6-8-26-13(2)28-19)11-31(32)22(23)21(12)30-35(33,34)18-4-3-15(24)10-17(18)25/h3-11,30H,1-2H3,(H,26,27,28,29)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337824
PNG
(US9751854, Compound I-7 | US9802960, Compound I-7)
Show SMILES CC(C)NS(=O)(=O)c1cc(cnc1N)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C15H19N5O3S/c1-9(2)20-24(22,23)13-6-12(8-18-15(13)16)11-4-5-17-14(7-11)19-10(3)21/h4-9,20H,1-3H3,(H2,16,18)(H,17,19,21)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337849
PNG
(US9751854, Compound I-32 | US9802960, Compound I-3...)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C15H19N5O3S/c1-10-14(19-24(22,23)20(3)4)7-13(9-17-10)12-5-6-16-15(8-12)18-11(2)21/h5-9,19H,1-4H3,(H,16,18,21)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337860
PNG
(US9751854, Compound I-43 | US9802960, Compound I-4...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(N)c(c1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C18H17N5O3S/c1-12(24)22-17-10-13(7-8-20-17)14-9-16(18(19)21-11-14)27(25,26)23-15-5-3-2-4-6-15/h2-11,23H,1H3,(H2,19,21)(H,20,22,24)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337879
PNG
(US9751854, Compound I-62 | US9802960, Compound I-6...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C20H17F3N4O3S/c1-12-17(27-31(29,30)18-6-4-3-5-16(18)20(21,22)23)9-15(11-25-12)14-7-8-24-19(10-14)26-13(2)28/h3-11,27H,1-2H3,(H,24,26,28)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337899
PNG
(US9751854, Compound I-80 | US9802960, Compound I-8...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(C)cc2)c1
Show InChI InChI=1S/C20H20N4O3S/c1-13-4-6-18(7-5-13)28(26,27)24-19-10-17(12-22-14(19)2)16-8-9-21-20(11-16)23-15(3)25/h4-12,24H,1-3H3,(H,21,23,25)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337906
PNG
(US9751854, Compound I-87 | US9802960, Compound I-8...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(N)c(c1)S(=O)(=O)N1CCCC1
Show InChI InChI=1S/C16H19N5O3S/c1-11(22)20-15-9-12(4-5-18-15)13-8-14(16(17)19-10-13)25(23,24)21-6-2-3-7-21/h4-5,8-10H,2-3,6-7H2,1H3,(H2,17,19)(H,18,20,22)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337965
PNG
(US9751854, Compound I-141 | US9802960, Compound I-...)
Show SMILES CNc1ncc(cc1N(CC1CC1)S(C)(=O)=O)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C18H23N5O3S/c1-12(24)22-17-9-14(6-7-20-17)15-8-16(18(19-2)21-10-15)23(27(3,25)26)11-13-4-5-13/h6-10,13H,4-5,11H2,1-3H3,(H,19,21)(H,20,22,24)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337967
PNG
(US9751854, Compound I-143 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2cc(ccc2F)C(F)(F)F)c1
Show InChI InChI=1S/C20H16F4N4O3S/c1-11-17(7-14(10-26-11)13-5-6-25-19(8-13)27-12(2)29)28-32(30,31)18-9-15(20(22,23)24)3-4-16(18)21/h3-10,28H,1-2H3,(H,25,27,29)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337977
PNG
(US9751854, Compound I-153 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2F)c1C
Show InChI InChI=1S/C19H15ClF2N4O3S/c1-10-14(12-5-6-23-17(7-12)25-11(2)27)9-24-19(20)18(10)26-30(28,29)16-4-3-13(21)8-15(16)22/h3-9,26H,1-2H3,(H,23,25,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337987
PNG
(US9751854, Compound I-163 | US9802960, Compound I-...)
Show SMILES COc1ccc(c(F)c1)S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C20H19FN4O4S/c1-12-18(25-30(27,28)19-5-4-16(29-3)10-17(19)21)8-15(11-23-12)14-6-7-22-20(9-14)24-13(2)26/h4-11,25H,1-3H3,(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337992
PNG
(US9751854, Compound I-168 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C20H17F3N4O3S/c1-12-18(27-31(29,30)17-5-3-4-16(10-17)20(21,22)23)8-15(11-25-12)14-6-7-24-19(9-14)26-13(2)28/h3-11,27H,1-2H3,(H,24,26,28)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337997
PNG
(US9751854, Compound I-173 | US9802960, Compound I-...)
Show SMILES CNc1ncc(cc1S(=O)(=O)N(C(C)C)C(C)C)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C19H27N5O3S/c1-12(2)24(13(3)4)28(26,27)17-9-16(11-22-19(17)20-6)15-7-8-21-18(10-15)23-14(5)25/h7-13H,1-6H3,(H,20,22)(H,21,23,25)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338007
PNG
(US9751854, Compound I-183 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(N)c(c1)S(=O)(=O)NCC1CCCCC1
Show InChI InChI=1S/C19H25N5O3S/c1-13(25)24-18-10-15(7-8-21-18)16-9-17(19(20)22-12-16)28(26,27)23-11-14-5-3-2-4-6-14/h7-10,12,14,23H,2-6,11H2,1H3,(H2,20,22)(H,21,24,25)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338032
PNG
(US9751854, Compound I-207 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(N)c(c1)S(=O)(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C18H16ClN5O3S/c1-11(25)23-17-9-12(6-7-21-17)13-8-16(18(20)22-10-13)28(26,27)24-15-4-2-14(19)3-5-15/h2-10,24H,1H3,(H2,20,22)(H,21,23,25)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338100
PNG
(US9751854, Compound I-276 | US9802960, Compound I-...)
Show SMILES Cc1cccc(Nc2cc(ccn2)-c2cnc(C)c(NS(=O)(=O)c3ccc(F)cc3F)c2)n1
Show InChI InChI=1S/C23H19F2N5O2S/c1-14-4-3-5-22(28-14)29-23-11-16(8-9-26-23)17-10-20(15(2)27-13-17)30-33(31,32)21-7-6-18(24)12-19(21)25/h3-13,30H,1-2H3,(H,26,28,29)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338099
PNG
(US9751854, Compound I-275 | US9802960, Compound I-...)
Show SMILES CN(C(=O)c1cc(cnc1C)-c1ccnc(Nc2ccnc(C)n2)c1)C12CC(C1)C2
Show InChI InChI=1S/C23H24N6O/c1-14-19(22(30)29(3)23-10-16(11-23)12-23)8-18(13-26-14)17-4-6-25-21(9-17)28-20-5-7-24-15(2)27-20/h4-9,13,16H,10-12H2,1-3H3,(H,24,25,27,28)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338106
PNG
(US9751854, Compound I-282 | US9802960, Compound I-...)
Show SMILES Cc1c(NS(=O)(=O)c2ccc(F)cc2F)c(Cl)ncc1-c1ccnc(Nc2ccncn2)c1
Show InChI InChI=1S/C21H15ClF2N6O2S/c1-12-15(13-4-7-26-19(8-13)29-18-5-6-25-11-28-18)10-27-21(22)20(12)30-33(31,32)17-3-2-14(23)9-16(17)24/h2-11,30H,1H3,(H,25,26,28,29)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338132
PNG
(US9751854, Compound I-308 | US9802960, Compound I-...)
Show SMILES Cc1c(NS(=O)(=O)c2ccc(F)cc2F)c(Cl)ncc1-c1ccnc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C21H17ClF2N4O3S/c1-11-15(13-6-7-25-18(8-13)27-21(29)12-2-3-12)10-26-20(22)19(11)28-32(30,31)17-5-4-14(23)9-16(17)24/h4-10,12,28H,2-3H2,1H3,(H,25,27,29)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM352759
PNG
(US9802960, Compound I-342)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(Cl)c(NS(=O)(=O)c2cccc(Cl)c2Cl)c1
Show InChI InChI=1S/C18H13Cl3N4O3S/c1-10(26)24-16-8-11(5-6-22-16)12-7-14(18(21)23-9-12)25-29(27,28)15-4-2-3-13(19)17(15)20/h2-9,25H,1H3,(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338301
PNG
(US9751854, Compound I-486 | US9802960, Compound I-...)
Show SMILES Cc1nccc(Nc2cc(ccn2)-c2cc(NS(=O)(=O)c3ccc(F)cc3F)c3ccnn3c2)n1
Show InChI InChI=1S/C23H17F2N7O2S/c1-14-26-8-6-22(29-14)30-23-11-15(4-7-27-23)16-10-19(20-5-9-28-32(20)13-16)31-35(33,34)21-3-2-17(24)12-18(21)25/h2-13,31H,1H3,(H,26,27,29,30)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337955
PNG
(US9751854, Compound I-131 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)c1
Show InChI InChI=1S/C23H26N4O3S/c1-15-21(27-31(29,30)20-8-6-19(7-9-20)23(3,4)5)12-18(14-25-15)17-10-11-24-22(13-17)26-16(2)28/h6-14,27H,1-5H3,(H,24,26,28)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337966
PNG
(US9751854, Compound I-142 | US9802960, Compound I-...)
Show SMILES COc1cc(C)ccc1S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C21H22N4O4S/c1-13-5-6-20(19(9-13)29-4)30(27,28)25-18-10-17(12-23-14(18)2)16-7-8-22-21(11-16)24-15(3)26/h5-12,25H,1-4H3,(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338006
PNG
(US9751854, Compound I-182 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(C)cc2F)c1
Show InChI InChI=1S/C20H19FN4O3S/c1-12-4-5-19(17(21)8-12)29(27,28)25-18-9-16(11-23-13(18)2)15-6-7-22-20(10-15)24-14(3)26/h4-11,25H,1-3H3,(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338080
PNG
(US9751854, Compound I-255 | US9802960, Compound I-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(Cl)c(NS(=O)(=O)c2ccc(F)cc2F)c1C
Show InChI InChI=1S/C19H15ClF2N4O4S/c1-10-13(11-5-6-23-16(7-11)25-19(27)30-2)9-24-18(20)17(10)26-31(28,29)15-4-3-12(21)8-14(15)22/h3-9,26H,1-2H3,(H,23,25,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338097
PNG
(US9751854, Compound I-273 | US9802960, Compound I-...)
Show SMILES CCN(C)S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C16H21N5O3S/c1-5-21(4)25(23,24)20-15-8-14(10-18-11(15)2)13-6-7-17-16(9-13)19-12(3)22/h6-10,20H,5H2,1-4H3,(H,17,19,22)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338134
PNG
(US9751854, Compound I-310 | US9802960, Compound I-...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccnc(Nc2cnccn2)c1
Show InChI InChI=1S/C21H16F2N6O2S/c1-13-18(29-32(30,31)19-3-2-16(22)10-17(19)23)8-15(11-27-13)14-4-5-25-20(9-14)28-21-12-24-6-7-26-21/h2-12,29H,1H3,(H,25,26,28)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338171
PNG
(US9751854, Compound I-350 | US9802960, Compound I-...)
Show SMILES CCCCN(CCCC)S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C21H31N5O3S/c1-5-7-11-26(12-8-6-2)30(28,29)25-20-13-19(15-23-16(20)3)18-9-10-22-21(14-18)24-17(4)27/h9-10,13-15,25H,5-8,11-12H2,1-4H3,(H,22,24,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338194
PNG
(US9751854, Compound I-375 | US9802960, Compound I-...)
Show SMILES COc1nc(C)nc(Nc2cc(ccn2)-c2cnc(C)c(NS(=O)(=O)c3ccc(F)cc3F)c2)n1
Show InChI InChI=1S/C22H19F2N7O3S/c1-12-18(31-35(32,33)19-5-4-16(23)10-17(19)24)8-15(11-26-12)14-6-7-25-20(9-14)29-21-27-13(2)28-22(30-21)34-3/h4-11,31H,1-3H3,(H,25,27,28,29,30)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338207
PNG
(US9751854, Compound I-389 | US9802960, Compound I-...)
Show SMILES CCOC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(F)cc2F)c1
Show InChI InChI=1S/C20H18F2N4O4S/c1-3-30-20(27)25-19-9-13(6-7-23-19)14-8-17(12(2)24-11-14)26-31(28,29)18-5-4-15(21)10-16(18)22/h4-11,26H,3H2,1-2H3,(H,23,25,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338243
PNG
(US9751854, Compound I-427 | US9802960, Compound I-...)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cn2nccc12)-c1ccnc(Nc2ccnc(n2)C2CC2)c1
Show InChI InChI=1S/C21H22N8O2S/c1-28(2)32(30,31)27-17-11-16(13-29-18(17)6-10-24-29)15-5-8-22-20(12-15)25-19-7-9-23-21(26-19)14-3-4-14/h5-14,27H,3-4H2,1-2H3,(H,22,23,25,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338257
PNG
(US9751854, Compound I-441 | US9802960, Compound I-...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)c1ccc(Cl)cc1F)-c1ccnc(NC(=O)C2CC2(F)F)c1
Show InChI InChI=1S/C21H16ClF3N4O3S/c1-11-17(29-33(31,32)18-3-2-14(22)8-16(18)23)6-13(10-27-11)12-4-5-26-19(7-12)28-20(30)15-9-21(15,24)25/h2-8,10,15,29H,9H2,1H3,(H,26,28,30)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338271
PNG
(US9751854, Compound I-456 | US9802960, Compound I-...)
Show SMILES CCOC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(Cl)cc2F)c1
Show InChI InChI=1S/C20H18ClFN4O4S/c1-3-30-20(27)25-19-9-13(6-7-23-19)14-8-17(12(2)24-11-14)26-31(28,29)18-5-4-15(21)10-16(18)22/h4-11,26H,3H2,1-2H3,(H,23,25,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337893
PNG
(US9751854, Compound I-74 | US9802960, Compound I-7...)
Show SMILES COc1ccccc1S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C20H20N4O4S/c1-13-17(24-29(26,27)19-7-5-4-6-18(19)28-3)10-16(12-22-13)15-8-9-21-20(11-15)23-14(2)25/h4-12,24H,1-3H3,(H,21,23,25)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337920
PNG
(US9751854, Compound I-101 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(N)c(c1)S(=O)(=O)NC1CCCCC1
Show InChI InChI=1S/C18H23N5O3S/c1-12(24)22-17-10-13(7-8-20-17)14-9-16(18(19)21-11-14)27(25,26)23-15-5-3-2-4-6-15/h7-11,15,23H,2-6H2,1H3,(H2,19,21)(H,20,22,24)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337949
PNG
(US9751854, Compound I-125 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(N)c(c1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C21H19N5O2/c1-13(27)25-19-9-14(6-7-23-19)17-8-18(20(22)24-10-17)21(28)26-11-15-4-2-3-5-16(15)12-26/h2-10H,11-12H2,1H3,(H2,22,24)(H,23,25,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337983
PNG
(US9751854, Compound I-159 | US9802960, Compound I-...)
Show SMILES COc1cc(F)c(cc1F)S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C20H18F2N4O4S/c1-11-17(26-31(28,29)19-9-15(21)18(30-3)8-16(19)22)6-14(10-24-11)13-4-5-23-20(7-13)25-12(2)27/h4-10,26H,1-3H3,(H,23,25,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337985
PNG
(US9751854, Compound I-161 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(c(F)cn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(F)cc2F)c1
Show InChI InChI=1S/C19H15F3N4O3S/c1-10-17(26-30(28,29)18-4-3-13(20)6-15(18)21)5-12(8-23-10)14-7-19(25-11(2)27)24-9-16(14)22/h3-9,26H,1-2H3,(H,24,25,27)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM337994
PNG
(US9751854, Compound I-170 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(N)c(c1)S(=O)(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C18H15F2N5O3S/c1-10(26)24-17-7-11(4-5-22-17)12-6-16(18(21)23-9-12)29(27,28)25-15-3-2-13(19)8-14(15)20/h2-9,25H,1H3,(H2,21,23)(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338030
PNG
(US9751854, Compound I-206 | US9802960, Compound I-...)
Show SMILES CC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(F)cc2Cl)c1
Show InChI InChI=1S/C19H16ClFN4O3S/c1-11-17(25-29(27,28)18-4-3-15(21)9-16(18)20)7-14(10-23-11)13-5-6-22-19(8-13)24-12(2)26/h3-10,25H,1-2H3,(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338053
PNG
(US9751854, Compound I-228 | US9802960, Compound I-...)
Show SMILES Cc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccnc(Nc2ccc(cn2)C#N)c1
Show InChI InChI=1S/C23H16F2N6O2S/c1-14-20(31-34(32,33)21-4-3-18(24)10-19(21)25)8-17(13-28-14)16-6-7-27-23(9-16)30-22-5-2-15(11-26)12-29-22/h2-10,12-13,31H,1H3,(H,27,29,30)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338054
PNG
(US9751854, Compound I-229 | US9802960, Compound I-...)
Show SMILES CN(C)S(=O)(=O)Nc1cc(cnc1C)-c1ccnc(Nc2ccc(C#N)c(C)n2)c1
Show InChI InChI=1S/C20H21N7O2S/c1-13-16(11-21)5-6-19(24-13)25-20-10-15(7-8-22-20)17-9-18(14(2)23-12-17)26-30(28,29)27(3)4/h5-10,12,26H,1-4H3,(H,22,24,25)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM352681
PNG
(US9802960, Compound I-259)
Show SMILES CCc1c(NS(=O)(=O)c2ccc(F)cc2F)c(C)ncc1-c1ccnc(Nc2ccnc(C)n2)c1
Show InChI InChI=1S/C24H22F2N6O2S/c1-4-18-19(16-7-9-28-23(11-16)31-22-8-10-27-15(3)30-22)13-29-14(2)24(18)32-35(33,34)21-6-5-17(25)12-20(21)26/h5-13,32H,4H2,1-3H3,(H,27,28,30,31)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338233
PNG
(US9751854, Compound I-417 | US9802960, Compound I-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(C)c(NS(=O)(=O)c2ccc(Cl)cc2F)c1
Show InChI InChI=1S/C19H16ClFN4O4S/c1-11-16(25-30(27,28)17-4-3-14(20)9-15(17)21)7-13(10-23-11)12-5-6-22-18(8-12)24-19(26)29-2/h3-10,25H,1-2H3,(H,22,24,26)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))		BDBM338244
PNG
(US9751854, Compound I-428 | US9802960, Compound I-...)
Show SMILES CN(C)S(=O)(=O)Oc1cc(cn2nccc12)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1S/C16H17N5O4S/c1-11(22)19-16-9-12(4-6-17-16)13-8-15(25-26(23,24)20(2)3)14-5-7-18-21(14)10-13/h4-10H,1-3H3,(H,17,19,22)
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Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...

US Patent US9802960 (2017)


BindingDB Entry DOI: 10.7270/Q2D79DJ9
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%