| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM50250631 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1682036 (CHEMBL4032313) |
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| Ki | 0.772000±n/a nM |
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| Citation |  Kurata, H; Kusumi, K; Otsuki, K; Suzuki, R; Kurono, M; Komiya, T; Hagiya, H; Mizuno, H; Shioya, H; Ono, T; Takada, Y; Maeda, T; Matsunaga, N; Kondo, T; Tominaga, S; Nunoya, KI; Kiyoshi, H; Komeno, M; Nakade, S; Habashita, H Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P J Med Chem60:9508-9530 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | CD_antigen=CD363 | Edg1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor 1 | S1P receptor Edg-1 | S1P1 | S1PR1_RAT | S1pr1 | Sphingosine 1-phosphate receptor Edg-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42770.88 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1463793 |
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| Residue: | 383 |
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| Sequence: | MVSSTSIPVVKALRSQVSDYGNYDIIVRHYNYTGKLNIGVEKDHGIKLTSVVFILICCLI
ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFL
REGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPI
MGWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRK
NISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVL
AVLNSGTNPIIYTLTNKEMRRAFIRIISCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSS
HPQKDDGDNPETIMSSGNVNSSS
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| BDBM50250631 |
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| n/a |
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| Name | BDBM50250631 |
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| Synonyms: | CHEMBL4093489 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33NO4 |
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| Mol. Mass. | 435.5552 |
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| SMILES | CCCc1ccc(COc2ccc3C(C)=C(CN4CC(C4)C(O)=O)CCc3c2)c(OC)c1 |t:14| |
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| Structure | 
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