| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase protein |
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| Ligand | BDBM50484634 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_798903 (CHEMBL1943410) |
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| Ki | 5.3±n/a nM |
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| Citation |  Gomez, R; Jolly, SJ; Williams, T; Vacca, JP; Torrent, M; McGaughey, G; Lai, MT; Felock, P; Munshi, V; Distefano, D; Flynn, J; Miller, M; Yan, Y; Reid, J; Sanchez, R; Liang, Y; Paton, B; Wan, BL; Anthony, N Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase. J Med Chem54:7920-33 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase protein |
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| Name: | Reverse transcriptase protein |
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| Synonyms: | Reverse Transcriptase | Reverse Transcriptase (A62V) | Reverse Transcriptase (F61A) |
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| Type: | Protein |
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| Mol. Mass.: | 30203.56 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WJQ2 |
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| Residue: | 259 |
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| Sequence: | PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWT
VQPIVLPEKDSWTVNDIQK
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| BDBM50484634 |
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| n/a |
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| Name | BDBM50484634 |
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| Synonyms: | CHEMBL1939504 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H12Cl2N6O |
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| Mol. Mass. | 435.266 |
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| SMILES | Clc1cc(Oc2c(Cl)ccc3n(Cc4n[nH]c5ncccc45)cnc23)cc(c1)C#N |
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| Structure | 
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