Reaction Details |
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Target | Histone-lysine N-methyltransferase SMYD3 |
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Ligand | BDBM50502419 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1807501 (CHEMBL4306860) |
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IC50 | 1200±n/a nM |
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Citation | Huang, C; Liew, SS; Lin, GR; Poulsen, A; Ang, MJY; Chia, BCS; Chew, SY; Kwek, ZP; Wee, JLK; Ong, EH; Retna, P; Baburajendran, N; Li, R; Yu, W; Koh-Stenta, X; Ngo, A; Manesh, S; Fulwood, J; Ke, Z; Chung, HH; Sepramaniam, S; Chew, XH; Dinie, N; Lee, MA; Chew, YS; Low, CB; Pendharkar, V; Manoharan, V; Vuddagiri, S; Sangthongpitag, K; Joy, J; Matter, A; Hill, J; Keller, TH; Foo, K Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3. ACS Med Chem Lett10:978-984 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone-lysine N-methyltransferase SMYD3 |
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Name: | Histone-lysine N-methyltransferase SMYD3 |
Synonyms: | SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1 |
Type: | Enzyme |
Mol. Mass.: | 49101.22 |
Organism: | Homo sapiens (Human) |
Description: | Q9H7B4-2 |
Residue: | 428 |
Sequence: | MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM
RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES
EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL
DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW
KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE
CDANIRAS
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BDBM50502419 |
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n/a |
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Name | BDBM50502419 |
Synonyms: | CHEMBL4462956 |
Type | Small organic molecule |
Emp. Form. | C23H29ClN4O3 |
Mol. Mass. | 444.954 |
SMILES | CCCOC(=O)N1CCN(CC1)C(=O)c1ccc2c(Cl)c3CC(CN)CCc3nc2c1 |
Structure |
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