Reaction Details | |||
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Target | JAK3/JAK1 | ||
Ligand | BDBM50527405 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1902606 (CHEMBL4404828) | ||
IC50 | 47±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Assay Method | ||
JAK3/JAK1 | |||
Name: | JAK3/JAK1 | ||
Synonyms: | Tyrosine-protein kinase JAK1/JAK3 | ||
Type: | n/a | ||
Mol. Mass.: | n/a | ||
Description: | ASSAY_ID of ChEMBL is 2193386 | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Tyrosine-protein kinase JAK3 | ||
Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
Type: | Protein | ||
Mol. Mass.: | 125111.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P52333 | ||
Residue: | 1124 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Tyrosine-protein kinase JAK1 | ||
Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
Type: | Protein | ||
Mol. Mass.: | 133293.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458 | ||
Residue: | 1154 | ||
Sequence: |
| ||
BDBM50527405 | |||
n/a | |||
Name | BDBM50527405 | ||
Synonyms: | CHEMBL4456630 | US10981911, Example 26 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H35N7O2 | ||
Mol. Mass. | 489.6125 | ||
SMILES | O=C(Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](CC#N)CC1)N1CCC(CC1)N1CCOCC1 |r,wU:15.17,wD:18.21,(59.72,-29.37,;60.49,-28.03,;62.03,-28.03,;62.8,-29.36,;62.18,-30.76,;63.32,-31.78,;63.32,-33.33,;64.65,-34.1,;65.98,-33.33,;67.46,-33.81,;68.37,-32.55,;67.46,-31.3,;65.98,-31.78,;64.64,-31.02,;64.32,-29.52,;65.35,-28.37,;64.88,-26.92,;65.91,-25.77,;67.42,-26.09,;68.45,-24.95,;69.96,-25.28,;71.47,-25.61,;67.89,-27.56,;66.86,-28.7,;59.72,-26.7,;60.49,-25.37,;59.73,-24.04,;58.19,-24.03,;57.41,-25.37,;58.18,-26.71,;57.42,-22.7,;58.2,-21.37,;57.43,-20.04,;55.89,-20.03,;55.12,-21.36,;55.88,-22.7,)| | ||
Structure | ![]() |