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TargetCytochrome P450 1A2
LigandBDBM50536194
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1933085 (CHEMBL4478737)
IC50>100000±n/a nM
Citation Norcross, NRBaragaña, BWilson, CHallyburton, IOsuna-Cabello, MNorval, SRiley, JStojanovski, LSimeons, FRPorzelle, AGrimaldi, RWittlin, SDuffy, SAvery, VMMeister, SSanz, LJiménez-Díaz, BAngulo-Barturen, IFerrer, SMartínez, MSGamo, FJFrearson, JAGray, DWFairlamb, AHWinzeler, EAWaterson, DCampbell, SFWillis, PRead, KDGilbert, IH Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. J Med Chem59:6101-20 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 1A2
Name:Cytochrome P450 1A2
Synonyms:CP1A2_HUMAN | CYP1A2 | CYPIA2 | Cholesterol 25-hydroxylase | Cytochrome P(3)450 | Cytochrome P450 1A | Cytochrome P450 1A2 (CYP1A2) | Cytochrome P450 4 | Cytochrome P450-P3
Type:Enzyme
Mol. Mass.:58423.38
Organism:Homo sapiens (Human)
Description:P05177
Residue:516
Sequence:
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50536194
n/a
NameBDBM50536194
Synonyms:CHEMBL4569641
TypeSmall organic molecule
Emp. Form.C24H28N6O
Mol. Mass.416.5187
SMILESC(C1CCN(CC1)c1cc(nc(n1)-c1ccncc1)-c1cccnc1)N1CCOCC1
Structure
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