Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase Tec |
---|
Ligand | BDBM164638 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1983372 (CHEMBL4616778) |
---|
IC50 | 0.900000±n/a nM |
---|
Citation | Watterson, SH; Liu, Q; Beaudoin Bertrand, M; Batt, DG; Li, L; Pattoli, MA; Skala, S; Cheng, L; Obermeier, MT; Moore, R; Yang, Z; Vickery, R; Elzinga, PA; Discenza, L; D'Arienzo, C; Gillooly, KM; Taylor, TL; Pulicicchio, C; Zhang, Y; Heimrich, E; McIntyre, KW; Ruan, Q; Westhouse, RA; Catlett, IM; Zheng, N; Chaudhry, C; Dai, J; Galella, MA; Tebben, AJ; Pokross, M; Li, J; Zhao, R; Smith, D; Rampulla, R; Allentoff, A; Wallace, MA; Mathur, A; Salter-Cid, L; Macor, JE; Carter, PH; Fura, A; Burke, JR; Tino, JA Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK). J Med Chem62:3228-3250 (2019) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase Tec |
---|
Name: | Tyrosine-protein kinase Tec |
Synonyms: | PSCTK4 | TEC | TEC_HUMAN | Tyrosine-protein kinase TEC (TEC) |
Type: | Protein |
Mol. Mass.: | 73597.00 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 631 |
Sequence: | MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK
CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY
HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS
EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN
NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY
HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY
EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL
THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL
ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS
RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR
CWQEKPEGRPSFEDLLRTIDELVECEETFGR
|
|
|
BDBM164638 |
---|
n/a |
---|
Name | BDBM164638 |
Synonyms: | BDBM166759 | US10604504, Example 223 | US11623921, Example 223 | US9688629, 123 | US9802915, Example 123 | US9920031, Example 223 |
Type | Small organic molecule |
Emp. Form. | C20H23FN4O2 |
Mol. Mass. | 370.4206 |
SMILES | CC#CC(=O)N[C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12 |r| |
Structure |
|