Reaction Details |
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Target | Branched-chain-amino-acid aminotransferase, mitochondrial |
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Ligand | BDBM50173923 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1580973 |
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IC50 | 79±n/a nM |
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Citation | Deng, H; Zhou, J; Sundersingh, F; Messer, JA; Somers, DO; Ajakane, M; Arico-Muendel, CC; Beljean, A; Belyanskaya, SL; Bingham, R; Blazensky, E; Boullay, AB; Boursier, E; Chai, J; Carter, P; Chung, CW; Daugan, A; Ding, Y; Herry, K; Hobbs, C; Humphries, E; Kollmann, C; Nguyen, VL; Nicodeme, E; Smith, SE; Dodic, N; Ancellin, N Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors. ACS Med Chem Lett7:379-84 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Branched-chain-amino-acid aminotransferase, mitochondrial |
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Name: | Branched-chain-amino-acid aminotransferase, mitochondrial |
Synonyms: | BCAT(m) | BCAT2 | BCAT2_HUMAN | BCATM | BCATM | BCT2 | Branched-chain-amino-acid aminotransferase, mitochondrial | ECA40 | PP18 | Placental protein 18 |
Type: | PROTEIN |
Mol. Mass.: | 44297.81 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109874 |
Residue: | 392 |
Sequence: | MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV
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BDBM50173923 |
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n/a |
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Name | BDBM50173923 |
Synonyms: | CHEMBL3810317 |
Type | Small organic molecule |
Emp. Form. | C24H23BrN4O2S2 |
Mol. Mass. | 543.499 |
SMILES | CNC(=O)c1ccc2n([C@@H]3CCC[C@@H](C3)NC(=O)c3ccc(Br)s3)c(nc2c1)-c1cccs1 |r| |
Structure |
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