Ki Summary

Reaction Details

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Target

Non-receptor tyrosine-protein kinase TYK2

Ligand

BDBM325500

Substrate/Competitor

n/a

Meas. Tech.

Tyk2 Inhibition Assay

IC50

<10±n/a nM

Citation

Allen, S; Boys, ML; Chicarelli, MJ; Fell, JB; Fischer, JP; Gaudino, J; Hicken, EJ; Hinklin, RJ; Kraser, CF; Laird, E; Robinson, JE; Tang, TP; Burgess, LE; Rieger, RA; Pheneger, J; Satoh, Y; Leftheris, K; Raheja, RK; Bennett, BL 4,6-substituted-pyrazolo[1,5-a]pyrazines as Janus kinase inhibitors US Patent US10730880 Publication Date 8/4/2020

More Info.:

Get all data from this article, Assay Method

Non-receptor tyrosine-protein kinase TYK2

Name:

Non-receptor tyrosine-protein kinase TYK2

Synonyms:

Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2

Type:

Protein

Mol. Mass.:

133666.03

Organism:

Homo sapiens (Human)

Description:

P29597

Residue:

1187

Sequence:

MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC

BDBM325500

n/a

Name

BDBM325500

Synonyms:

(1s,3s)-1-methyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-6-yl)-1H-pyrazol-1-yl)cyclobutanol | US10189845, Example 162 | US10730880, Example 162

Type

Small organic molecule

Emp. Form.

C22H27N7O

Mol. Mass.

405.4961

SMILES

CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@](C)(O)C1 |r,wU:26.31,wD:26.30,(.46,9.04,;-.31,7.71,;.46,6.38,;2,6.38,;2.77,7.71,;-.31,5.04,;.17,3.58,;-1.08,2.67,;-2.33,3.58,;-1.85,5.04,;-1.08,1.13,;.25,.36,;.25,-1.18,;-1.08,-1.95,;-2.41,-1.18,;-3.88,-1.65,;-4.78,-.41,;-3.88,.84,;-2.41,.36,;1.59,-1.95,;3.05,-1.47,;3.96,-2.72,;3.05,-3.96,;1.59,-3.49,;3.45,-5.45,;4.78,-6.22,;4.01,-7.56,;3.24,-8.89,;4.41,-9.04,;2.68,-6.79,)|

Structure