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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM325501 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | JAK2 Inhibition Assay | ||
| IC50 | <10±n/a nM | ||
| Citation |  Allen, S; Boys, ML; Chicarelli, MJ; Fell, JB; Fischer, JP; Gaudino, J; Hicken, EJ; Hinklin, RJ; Kraser, CF; Laird, E; Robinson, JE; Tang, TP; Burgess, LE; Rieger, RA; Pheneger, J; Satoh, Y; Leftheris, K; Raheja, RK; Bennett, BL 4,6-substituted-pyrazolo[1,5-a]pyrazines as Janus kinase inhibitors US Patent US10730880 Publication Date 8/4/2020 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
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| BDBM325501 | |||
| n/a | |||
| Name | BDBM325501 | ||
| Synonyms: | US10189845, Example 163A | US10189845, Example 164B | US10730880, Example 164 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H27N7O2 | ||
| Mol. Mass. | 421.4955 | ||
| SMILES | CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@](O)(CO)C1 |r,wU:26.30,wD:26.31,(-.1,19.14,;-.87,17.8,;-.1,16.47,;1.44,16.47,;2.21,17.8,;-.87,15.13,;-.39,13.67,;-1.64,12.77,;-2.88,13.67,;-2.41,15.13,;-1.64,11.23,;-.3,10.46,;-.3,8.92,;-1.64,8.15,;-2.97,8.92,;-4.44,8.44,;-5.34,9.69,;-4.44,10.93,;-2.97,10.46,;1.03,8.15,;2.49,8.62,;3.4,7.38,;2.49,6.13,;1.03,6.61,;2.89,4.64,;2.12,3.31,;3.46,2.54,;5,2.54,;3.85,1.05,;5.34,.65,;4.23,3.87,)| | ||
| Structure | 
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