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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM502821 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | JAK2 Inhibition Assay | ||
| IC50 | <10±n/a nM | ||
| Citation |  Allen, S; Boys, ML; Chicarelli, MJ; Fell, JB; Fischer, JP; Gaudino, J; Hicken, EJ; Hinklin, RJ; Kraser, CF; Laird, E; Robinson, JE; Tang, TP; Burgess, LE; Rieger, RA; Pheneger, J; Satoh, Y; Leftheris, K; Raheja, RK; Bennett, BL 4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors US Patent US11028093 Publication Date 6/8/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
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| BDBM502821 | |||
| n/a | |||
| Name | BDBM502821 | ||
| Synonyms: | US11028093, Example 118 | trans-4-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-6-yl)-1H-pyrazol-1-yl)cyclohexanol | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H29N7O | ||
| Mol. Mass. | 419.5227 | ||
| SMILES | CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1CC[C@H](O)CC1 |r,wU:24.27,wD:27.31,(-1.81,6.37,;-2.71,5.12,;-2.09,3.72,;-.56,3.56,;.35,4.8,;-2.99,2.47,;-2.52,1.01,;-3.76,.1,;-5.01,1.01,;-4.53,2.47,;-3.76,-1.44,;-2.43,-2.21,;-2.43,-3.75,;-3.76,-4.52,;-5.1,-3.75,;-6.56,-4.22,;-7.47,-2.98,;-6.56,-1.73,;-5.1,-2.21,;-1.1,-4.52,;-.94,-6.05,;.57,-6.37,;1.34,-5.04,;.31,-3.89,;2.87,-4.88,;3.5,-3.47,;5.03,-3.31,;5.94,-4.55,;7.47,-4.39,;5.31,-5.96,;3.78,-6.12,)| | ||
| Structure | 
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