Ki Summary

Reaction Details

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Target

Non-receptor tyrosine-protein kinase TYK2

Ligand

BDBM325457

Substrate/Competitor

n/a

Meas. Tech.

Tyk2 Inhibition Assay

IC50

<10±n/a nM

Citation

Allen, S; Boys, ML; Chicarelli, MJ; Fell, JB; Fischer, JP; Gaudino, J; Hicken, EJ; Hinklin, RJ; Kraser, CF; Laird, E; Robinson, JE; Tang, TP; Burgess, LE; Rieger, RA; Pheneger, J; Satoh, Y; Leftheris, K; Raheja, RK; Bennett, BL 4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors US Patent US11028093 Publication Date 6/8/2021

More Info.:

Get all data from this article, Assay Method

Non-receptor tyrosine-protein kinase TYK2

Name:

Non-receptor tyrosine-protein kinase TYK2

Synonyms:

Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2

Type:

Protein

Mol. Mass.:

133666.03

Organism:

Homo sapiens (Human)

Description:

P29597

Residue:

1187

Sequence:

MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC

BDBM325457

n/a

Name

BDBM325457

Synonyms:

US10189845, Example 119 | US10730880, Example 119 | US11028093, Example 119 | cis-3-(4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)pyrazolo[1,5- a]pyrazin-6-yl)-1H- pyrazol-1-yl)cyclobutanol

Type

Small organic molecule

Emp. Form.

C21H25N7O

Mol. Mass.

391.4695

SMILES

CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@H](O)C1 |r,wU:26.30,(1.23,4.45,;.14,3.36,;-1.35,3.76,;-1.75,5.25,;-.66,6.34,;-2.44,2.67,;-1.96,1.21,;-3.21,.3,;-4.45,1.21,;-3.98,2.67,;-3.21,-1.24,;-1.87,-2.01,;-1.87,-3.55,;-3.21,-4.32,;-4.54,-3.55,;-6,-4.03,;-6.91,-2.78,;-6,-1.53,;-4.54,-2.01,;-.54,-4.32,;-.54,-5.86,;.93,-6.34,;1.83,-5.09,;.93,-3.84,;3.32,-4.69,;4.65,-5.46,;5.42,-4.13,;6.91,-3.73,;4.09,-3.36,)|

Structure