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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Non-receptor tyrosine-protein kinase TYK2 | ||
| Ligand | BDBM502873 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Tyk2 Inhibition Assay | ||
| IC50 | <10±n/a nM | ||
| Citation |  Allen, S; Boys, ML; Chicarelli, MJ; Fell, JB; Fischer, JP; Gaudino, J; Hicken, EJ; Hinklin, RJ; Kraser, CF; Laird, E; Robinson, JE; Tang, TP; Burgess, LE; Rieger, RA; Pheneger, J; Satoh, Y; Leftheris, K; Raheja, RK; Bennett, BL 4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors US Patent US11028093 Publication Date 6/8/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Non-receptor tyrosine-protein kinase TYK2 | |||
| Name: | Non-receptor tyrosine-protein kinase TYK2 | ||
| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133666.03 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P29597 | ||
| Residue: | 1187 | ||
| Sequence: |
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| BDBM502873 | |||
| n/a | |||
| Name | BDBM502873 | ||
| Synonyms: | (1s,3 s)-1-methyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-6-yl)-1H-pyrazol-1-yl)cyclobutanol | US11028093, Example 162 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H27N7O | ||
| Mol. Mass. | 405.4961 | ||
| SMILES | CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1C[C@@](C)(O)C1 |r,wU:24.27,26.31,wD:26.30,(.5,8.74,;-.41,7.49,;.22,6.08,;1.75,5.92,;2.66,7.17,;-.69,4.84,;-.21,3.37,;-1.46,2.47,;-2.7,3.37,;-2.23,4.84,;-1.46,.93,;-.12,.16,;-.12,-1.38,;-1.46,-2.15,;-2.79,-1.38,;-4.26,-1.86,;-5.16,-.61,;-4.26,.63,;-2.79,.16,;1.21,-2.15,;2.62,-1.53,;3.65,-2.67,;2.88,-4.01,;1.37,-3.68,;3.5,-5.41,;4.94,-5.96,;4.39,-7.4,;3.62,-8.74,;5.16,-8.74,;2.95,-6.85,)| | ||
| Structure | 
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