Reaction Details |
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Target | Reverse transcriptase protein |
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Ligand | BDBM50479470 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_798903 (CHEMBL1943410) |
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Ki | 0.390000±n/a nM |
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Citation | Gomez, R; Jolly, SJ; Williams, T; Vacca, JP; Torrent, M; McGaughey, G; Lai, MT; Felock, P; Munshi, V; Distefano, D; Flynn, J; Miller, M; Yan, Y; Reid, J; Sanchez, R; Liang, Y; Paton, B; Wan, BL; Anthony, N Design and synthesis of conformationally constrained inhibitors of non-nucleoside reverse transcriptase. J Med Chem54:7920-33 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase protein |
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Name: | Reverse transcriptase protein |
Synonyms: | Reverse Transcriptase | Reverse Transcriptase (A62V) | Reverse Transcriptase (F61A) |
Type: | Protein |
Mol. Mass.: | 30203.56 |
Organism: | Human immunodeficiency virus 1 |
Description: | Q9WJQ2 |
Residue: | 259 |
Sequence: | PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWT
VQPIVLPEKDSWTVNDIQK
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BDBM50479470 |
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n/a |
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Name | BDBM50479470 |
Synonyms: | CHEMBL489586 | MK-4965 |
Type | Small organic molecule |
Emp. Form. | C20H13Cl2N5O2 |
Mol. Mass. | 426.256 |
SMILES | Nc1ccc2c(COc3ccc(Cl)c(Oc4cc(Cl)cc(c4)C#N)c3)n[nH]c2n1 |
Structure |
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