Reaction Details |
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Target | Prostaglandin G/H synthase 2 |
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Ligand | BDBM50137419 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_159595 |
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IC50 | 450±n/a nM |
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Citation | Li, J; DeMello, KM; Cheng, H; Sakya, SM; Bronk, BS; Rafka, RJ; Jaynes, BH; Ziegler, CB; Kilroy, C; Mann, DW; Nimz, EL; Lynch, MP; Haven, ML; Kolosko, NL; Minich, ML; Li, C; Dutra, JK; Rast, B; Crosson, RM; Morton, BJ; Kirk, GW; Callaghan, KM; Koss, DA; Shavnya, A; Lund, LA; Seibel, SB; Petras, CF; Silvia, A Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine. Bioorg Med Chem Lett14:95-8 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 2 |
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Name: | Prostaglandin G/H synthase 2 |
Synonyms: | Cyclooxygenase-2 | Prostaglandin G/H synthase-2 |
Type: | PROTEIN |
Mol. Mass.: | 68982.35 |
Organism: | Canis familiaris |
Description: | ChEMBL_344386 |
Residue: | 604 |
Sequence: | MLARALVLCAALAVVRAANPCCSHPCQNQGICMSTGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLYLKPTPNTVHYILTHFKGVWNIVNNIPFLRNTIMKYVLTSRSHLIESPPTYNVNY
GYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGKKELPDSKEIVEKFLLRRKFIPDPQGT
NMMFAFFAQHFTHQFFKTDHKRGPAFTKGLGHGVDLNHVYGETLDRQHKLRLFKDGKMKY
QVIDGEVYPPTVKDTQVEMIYPPHVPEHLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIAAEFNTLYHWHPLLPDTLQIDDQEYNFQQFIYNNSILLEHGLTQFVESFSRQIAGRV
AGGRNVPAAVQQVAKASIDQSRQMKYQSLNEYRKRFRLKPYTSFEELTGEKEMAAGLEAL
YGDIDAMELYPALLVEKPRPDAIFGETMVEMGAPFSLKGLMGNPICSPDYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTAFSVQDGQLTKTVTINASSSHSGLDDINPTVLLKER
STEL
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BDBM50137419 |
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n/a |
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Name | BDBM50137419 |
Synonyms: | 2-[5-(4-Bromo-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-5-methanesulfonyl-pyridine | CHEMBL174586 |
Type | Small organic molecule |
Emp. Form. | C16H11BrF3N3O2S |
Mol. Mass. | 446.242 |
SMILES | CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Br)cc1)C(F)(F)F |
Structure |
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