| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 3 |
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| Ligand | BDBM50000102 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_976653 (CHEMBL2417028) |
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| IC50 | 41200±n/a nM |
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| Citation |  Nakada, K; Yoshikawa, M; Ide, S; Suemasa, A; Kawamura, S; Kobayashi, T; Masuda, E; Ito, Y; Hayakawa, W; Katayama, T; Yamada, S; Arisawa, M; Minami, M; Shuto, S Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports. Bioorg Med Chem21:4938-50 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent GABA transporter 3 |
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| Name: | Sodium- and chloride-dependent GABA transporter 3 |
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| Synonyms: | GABA transporter 3 | GABT3 | GAT-3 | GAT3 | S6A11_HUMAN | SLC6A11 | Solute carrier family 6 member 11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70607.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1454198 |
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| Residue: | 632 |
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| Sequence: | MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFV
LSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGIT
CWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENC
VEFQKLNVSNYSHVSLQNATSPVMEFWEHRVLAISDGIEHIGNLRWELALCLLAAWTICY
FCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWV
DAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMA
YEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVT
AVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVA
IFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKY
NNIYTYPAWGYGIGWLMALSSMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKL
GVSPRMVTVNDCDAKLKSDGTIAAITEKETHF
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| BDBM50000102 |
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| n/a |
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| Name | BDBM50000102 |
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| Synonyms: | 3-aminopropanoic acidbeta-alanine | Alanine-beta | CHEMBL297569 | beta-alanine | beta-aminopropionic acid | omega-aminopropionic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C3H7NO2 |
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| Mol. Mass. | 89.0932 |
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| SMILES | NCCC(O)=O |
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| Structure | 
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