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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM325499 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | JAK2 Inhibition Assay | ||
| IC50 | 55±n/a nM | ||
| Citation |  Allen, S; Boys, ML; Chicarelli, MJ; Fell, JB; Fischer, JP; Gaudino, J; Hicken, EJ; Hinklin, RJ; Kraser, CF; Laird, E; Robinson, JE; Tang, TP; Burgess, LE; Rieger, RA; Pheneger, J; Satoh, Y; Leftheris, K; Raheja, RK; Bennett, BL 4,6-substituted-pyrazolo[1,5-a]pyrazines as janus kinase inhibitors US Patent US10189845 Publication Date 1/29/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
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| BDBM325499 | |||
| n/a | |||
| Name | BDBM325499 | ||
| Synonyms: | US10189845, Example 161 | US10730880, Example 161 | US11028093, Example 161 | trans-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-6-yl)-1H-pyrazol-1-yl)cyclobutanol | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H25N7O | ||
| Mol. Mass. | 391.4695 | ||
| SMILES | CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1C[C@H](O)C1 |r,wU:26.30,wD:24.27,(-1.67,6.5,;-2.44,5.17,;-1.67,3.84,;-.13,3.84,;.64,5.17,;-2.44,2.5,;-1.96,1.04,;-3.21,.13,;-4.45,1.04,;-3.98,2.5,;-3.21,-1.41,;-1.87,-2.18,;-1.87,-3.72,;-3.21,-4.49,;-4.54,-3.72,;-6,-4.19,;-6.91,-2.95,;-6,-1.7,;-4.54,-2.18,;-.54,-4.49,;-.54,-6.03,;.93,-6.5,;1.83,-5.26,;.93,-4.01,;3.32,-4.86,;4.65,-5.63,;5.42,-4.3,;6.91,-3.9,;4.09,-3.53,)| | ||
| Structure | 
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