| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 3 |
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| Ligand | BDBM50250636 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1681996 (CHEMBL4032273) |
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| EC50 | 9300±n/a nM |
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| Citation |  Kurata, H; Kusumi, K; Otsuki, K; Suzuki, R; Kurono, M; Komiya, T; Hagiya, H; Mizuno, H; Shioya, H; Ono, T; Takada, Y; Maeda, T; Matsunaga, N; Kondo, T; Tominaga, S; Nunoya, KI; Kiyoshi, H; Komeno, M; Nakade, S; Habashita, H Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P J Med Chem60:9508-9530 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 3 |
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| Name: | Sphingosine 1-phosphate receptor 3 |
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| Synonyms: | C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42278.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99500 |
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| Residue: | 378 |
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| Sequence: | MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMV
LIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFV
ALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLH
NLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMA
LLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTL
ASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
SSCIMDKNAALQNGIFCN
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| BDBM50250636 |
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| n/a |
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| Name | BDBM50250636 |
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| Synonyms: | CHEMBL4085321 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H35NO4 |
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| Mol. Mass. | 449.5818 |
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| SMILES | COc1cc(CC(C)C)ccc1COc1ccc2C(C)=C(CN3CC(C3)C(O)=O)CCc2c1 |t:20| |
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| Structure | 
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