| Reaction Details |
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 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
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| Ligand | BDBM50267928 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1704128 (CHEMBL4055361) |
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| IC50 | 1.2±n/a nM |
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| Citation |  Imamura, K; Tomita, N; Kawakita, Y; Ito, Y; Ono, K; Nii, N; Miyazaki, T; Yonemori, K; Tawada, M; Sumi, H; Satoh, Y; Yamamoto, Y; Miyahisa, I; Sasaki, M; Satomi, Y; Hirayama, M; Nishigaki, R; Maezaki, H Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents. Bioorg Med Chem25:3768-3779 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stearoyl-CoA desaturase |
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| Name: | Stearoyl-CoA desaturase |
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| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41537.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00767 |
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| Residue: | 359 |
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| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
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| BDBM50267928 |
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| n/a |
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| Name | BDBM50267928 |
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| Synonyms: | CHEMBL4066506 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17F6N5OS |
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| Mol. Mass. | 489.437 |
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| SMILES | OCc1nsc(n1)-c1ccc(nn1)N1CCC(CC1)(c1ccc(cc1)C(F)(F)F)C(F)(F)F |
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| Structure | 
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