| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-lysine N-methyltransferase SMYD3 |
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| Ligand | BDBM50502416 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1807501 (CHEMBL4306860) |
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| IC50 | 170±n/a nM |
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| Citation |  Huang, C; Liew, SS; Lin, GR; Poulsen, A; Ang, MJY; Chia, BCS; Chew, SY; Kwek, ZP; Wee, JLK; Ong, EH; Retna, P; Baburajendran, N; Li, R; Yu, W; Koh-Stenta, X; Ngo, A; Manesh, S; Fulwood, J; Ke, Z; Chung, HH; Sepramaniam, S; Chew, XH; Dinie, N; Lee, MA; Chew, YS; Low, CB; Pendharkar, V; Manoharan, V; Vuddagiri, S; Sangthongpitag, K; Joy, J; Matter, A; Hill, J; Keller, TH; Foo, K Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3. ACS Med Chem Lett10:978-984 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-lysine N-methyltransferase SMYD3 |
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| Name: | Histone-lysine N-methyltransferase SMYD3 |
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| Synonyms: | SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 49101.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H7B4-2 |
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| Residue: | 428 |
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| Sequence: | MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM
RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES
EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL
DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW
KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE
CDANIRAS
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| BDBM50502416 |
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| n/a |
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| Name | BDBM50502416 |
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| Synonyms: | CHEMBL4472455 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26ClN3O3 |
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| Mol. Mass. | 451.945 |
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| SMILES | CCCOC(=O)N1CCN(C[C@H]1C)C(=O)c1ccc2c(Cl)cc(nc2c1)-c1ccccc1 |r| |
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| Structure | 
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