| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase TEM |
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| Ligand | BDBM50518892 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1873666 (CHEMBL4374955) |
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| Ki | 14170±n/a nM |
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| Citation |  Wang, YL; Liu, S; Yu, ZJ; Lei, Y; Huang, MY; Yan, YH; Ma, Q; Zheng, Y; Deng, H; Sun, Y; Wu, C; Yu, Y; Chen, Q; Wang, Z; Wu, Y; Li, GB Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-?-lactamases. J Med Chem62:7160-7184 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase TEM |
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| Name: | Beta-lactamase TEM |
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| Synonyms: | BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla |
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| Type: | Enzyme |
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| Mol. Mass.: | 31512.33 |
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| Organism: | Escherichia coli |
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| Description: | P62593 |
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| Residue: | 286 |
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| Sequence: | MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRP
EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
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| BDBM50518892 |
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| n/a |
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| Name | BDBM50518892 |
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| Synonyms: | CHEMBL4453017 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H15BFNO3S |
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| Mol. Mass. | 271.116 |
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| SMILES | C[C@H](CS)C(=O)N[C@H](B(O)O)c1ccc(F)cc1 |r| |
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| Structure | 
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