| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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| Ligand | BDBM50523271 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1889413 (CHEMBL4391167) |
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| IC50 | 41±n/a nM |
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| Citation |  Oukoloff, K; Coquelle, N; Bartolini, M; Naldi, M; Le Guevel, R; Bach, S; Josselin, B; Ruchaud, S; Catto, M; Pisani, L; Denora, N; Iacobazzi, RM; Silman, I; Sussman, JL; Buron, F; Colletier, JP; Jean, L; Routier, S; Renard, PY Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. Eur J Med Chem168:58-77 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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| Name: | Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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| Synonyms: | Glycogen synthase kinase-3 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 2105817 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | Glycogen synthase kinase 3 beta | Glycogen synthase kinase-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46774.42 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_939732 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTMVATPGQGPDRPQEVSYTDAK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQTNNTASASASNST
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| Component 2 |
| Name: | [Tau protein] kinase |
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| Synonyms: | GSK3A | Glycogen synthase kinase 3 alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51010.29 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_117799 |
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| Residue: | 483 |
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| Sequence: | MSGGAPSGGGPGGSGRARTSSFAEHGGGGGGSGGGPGGSASGPGGGGGGKPSVGAMGGGV
GASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLADTRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPIIYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATGYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAITLCSSLLEYTPSSRLSPLEACAHNFFDELRCPGTQLPNNRPLP
PLFNFSPGELTIQPSLNAILIPPHLRSPAGTASLTSSSQALSETPTGPDWQSTDATTPLT
NSS
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| BDBM50523271 |
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| n/a |
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| Name | BDBM50523271 |
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| Synonyms: | CHEMBL4566076 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18N4O2 |
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| Mol. Mass. | 346.3825 |
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| SMILES | O=C(Nc1cc(ccn1)C#C)Nc1cccc2C(=O)N3CCCCC3c12 |
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| Structure | 
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