| Reaction Details |
|---|
 | Report a problem with these data |
| Target | L-lactate dehydrogenase A chain |
|---|
| Ligand | BDBM50534318 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1928156 (CHEMBL4431228) |
|---|
| IC50 | 3.0±n/a nM |
|---|
| Citation |  Purkey, HE; Robarge, K; Chen, J; Chen, Z; Corson, LB; Ding, CZ; DiPasquale, AG; Dragovich, PS; Eigenbrot, C; Evangelista, M; Fauber, BP; Gao, Z; Ge, H; Hitz, A; Ho, Q; Labadie, SS; Lai, KW; Liu, W; Liu, Y; Li, C; Ma, S; Malek, S; O'Brien, T; Pang, J; Peterson, D; Salphati, L; Sideris, S; Ultsch, M; Wei, B; Yen, I; Yue, Q; Zhang, H; Zhou, A Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett7:896-901 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| L-lactate dehydrogenase A chain |
|---|
| Name: | L-lactate dehydrogenase A chain |
|---|
| Synonyms: | Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36694.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00338::PDB Code: 4ajp |
|---|
| Residue: | 332 |
|---|
| Sequence: | MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
|
|
|
|---|
| BDBM50534318 |
|---|
| n/a |
|---|
| Name | BDBM50534318 |
|---|
| Synonyms: | CHEMBL4576717 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H20ClFN2O2S2 |
|---|
| Mol. Mass. | 523.041 |
|---|
| SMILES | OC1=C(Sc2ccccc2Cl)C(=O)NC(C1)(c1ccsc1)c1cccc(Nc2ccc(F)cc2)c1 |c:1| |
|---|
| Structure | 
|
|---|
Search and Browse
