| Reaction Details |
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 | Report a problem with these data |
| Target | L-lactate dehydrogenase B chain |
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| Ligand | BDBM50534329 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1928157 (CHEMBL4431229) |
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| IC50 | 57±n/a nM |
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| Citation |  Purkey, HE; Robarge, K; Chen, J; Chen, Z; Corson, LB; Ding, CZ; DiPasquale, AG; Dragovich, PS; Eigenbrot, C; Evangelista, M; Fauber, BP; Gao, Z; Ge, H; Hitz, A; Ho, Q; Labadie, SS; Lai, KW; Liu, W; Liu, Y; Li, C; Ma, S; Malek, S; O'Brien, T; Pang, J; Peterson, D; Salphati, L; Sideris, S; Ultsch, M; Wei, B; Yen, I; Yue, Q; Zhang, H; Zhou, A Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett7:896-901 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| L-lactate dehydrogenase B chain |
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| Name: | L-lactate dehydrogenase B chain |
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| Synonyms: | L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46 |
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| Type: | Oxidoreductase; homotetramer |
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| Mol. Mass.: | 36635.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 334 |
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| Sequence: | MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLK
GEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKF
IIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLG
IHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAY
EVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG
LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
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| BDBM50534329 |
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| n/a |
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| Name | BDBM50534329 |
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| Synonyms: | CHEMBL4521960 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16ClNO3S2 |
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| Mol. Mass. | 429.94 |
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| SMILES | OC1=C(Sc2ccccc2Cl)C(=O)NC(C1)(c1ccsc1)c1ccc(O)cc1 |c:1| |
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| Structure | 
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