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TargetHuman immunodeficiency virus type 1 protease
LigandBDBM50127969
Substrate/Competitorn/a
Meas. Tech.ChEMBL_159455
IC50 0.030000±n/a nM
Citation Lu ZRaghavan SBohn JCharest MStahlhut MWRutkowski CASimcoe ALOlsen DBSchleif WACarella AGabryelski LJin LLin JHEmini EChapman KTata JR Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus. Bioorg Med Chem Lett 13:1821-4 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 protease
Name:Human immunodeficiency virus type 1 protease
Synonyms:Pol polyprotein
Type:Enzyme Subunit
Mol. Mass.:10781.16
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50127969
n/a
NameBDBM50127969
Synonyms:(R)-3-[(2R,4R)-2-Hydroxy-4-((3S,4S)-3-hydroxy-chroman-4-ylcarbamoyl)-5-phenyl-pentanoyl]-5,5-dimethyl-thiazolidine-4-carboxylic acid 2,6-dimethyl-benzylamide | CHEMBL52702
TypeSmall organic molecule
Emp. Form.C36H43N3O6S
Mol. Mass.645.808
SMILESCc1cccc(C)c1CNC(=O)[C@H]1N(CSC1(C)C)C(=O)[C@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)COc2ccccc12
Structure
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