| Reaction Details |
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 | Report a problem with these data |
| Target | Mineralocorticoid receptor |
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| Ligand | BDBM50167790 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304692 (CHEMBL876472) |
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| IC50 | >10000±n/a nM |
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| Citation |  Smith, CJ; Ali, A; Balkovec, JM; Graham, DW; Hammond, ML; Patel, GF; Rouen, GP; Smith, SK; Tata, JR; Einstein, M; Ge, L; Harris, GS; Kelly, TM; Mazur, P; Thompson, CM; Wang, CF; Williamson, JM; Miller, DK; Pandit, S; Santoro, JC; Sitlani, A; Yamin, TT; O'Neill, EA; Zaller, DM; Carballo-Jane, E; Forrest, MJ; Luell, S Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity. Bioorg Med Chem Lett15:2926-31 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mineralocorticoid receptor |
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| Name: | Mineralocorticoid receptor |
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| Synonyms: | MCR_RAT | MR | Mineralocorticoid Receptor (MR) | Mineralocorticoid receptor | Mlr | Nr3c2 | Nuclear receptor subfamily 3 group C member 2 | mineralocorticoid |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 106748.15 |
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| Organism: | RAT |
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| Description: | mineralocorticoid 0 RAT::P22199 |
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| Residue: | 981 |
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| Sequence: | METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTTENNYMEIVNVSCVSGAIPNNST
QGSSKEKHELLPYIQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVRDAEYTYD
QQNQQGSLSPTKIYQNMEQLVKFYKENGHRSSTLSAMSRPLRSFMPDSAASMNGGALRAI
VKSPIICHEKSSSVSSPLNMASSVCSPVGINSMSSSTTSFGSFPVHSPITQGTSLTCSPS
VENRGSRSHSPTHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVPLRSSVSSP
ANLNNSRCSVSSPSNNTNNRSTLSSPTASTVGSIGSPISNAFSYATSGASAGAGAIQDVV
PSPDTHEKGAHDVPFPKTEEVEKAISNGVTGPLNIVQYIKSEPDGAFSSSCLGGNSKISP
SSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPG
FDGSCEDSAFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSP
RDQSFQHLSSFPPVNTLVESWKPHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRP
SKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACR
LQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSAL
VPQLTSITHALTPSPAMILENIEPETVYAGYDNSKPDTAESLLSTLNRLAAKQMIQVVKW
AKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQLLYFAPDLVFNEEKMHQS
AMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKEL
RKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEI
ITDQLPKVESGNAKPLYFHRK
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| BDBM50167790 |
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| n/a |
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| Name | BDBM50167790 |
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| Synonyms: | 1-(4-fluorophenyl)-4',4a,6'-trimethyl-(4'S,4aS,6'S)-spiro[1,4,4a,5,6,7-hexahydrocyclopenta[f]indazole-5,2'-(dihydro-4'H-[1,3]dioxane)] | CHEMBL434183 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25FN2O2 |
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| Mol. Mass. | 368.4445 |
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| SMILES | C[C@H]1C[C@H](C)O[C@@]2(CCC3=Cc4c(C[C@]23C)cnn4-c2ccc(F)cc2)O1 |t:9| |
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| Structure | 
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