| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-alpha |
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| Ligand | BDBM50305487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_604018 (CHEMBL1049546) |
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| IC50 | 543±n/a nM |
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| Citation |  Hu, B; Bernotas, R; Unwalla, R; Collini, M; Quinet, E; Feingold, I; Goos-Nilsson, A; Wilhelmsson, A; Nambi, P; Evans, M; Wrobel, J Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration. Bioorg Med Chem Lett20:689-93 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxysterols receptor LXR-alpha |
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| Name: | Oxysterols receptor LXR-alpha |
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| Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50403.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13133 |
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| Residue: | 447 |
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| Sequence: | MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
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| BDBM50305487 |
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| n/a |
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| Name | BDBM50305487 |
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| Synonyms: | 8-chloro-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)quinoline-3-carboxamide | CHEMBL593267 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H17ClN2O4S |
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| Mol. Mass. | 452.91 |
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| SMILES | CS(=O)(=O)c1cccc(Oc2cccc(c2)-c2c(cnc3c(Cl)cccc23)C(N)=O)c1 |
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| Structure | 
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