Reaction Details |
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Target | Ephrin type-B receptor 4 |
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Ligand | BDBM50329055 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_674154 (CHEMBL1274251) |
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IC50 | 205±n/a nM |
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Citation | Bardelle, C; Barlaam, B; Brooks, N; Coleman, T; Cross, D; Ducray, R; Green, I; Brempt, CL; Olivier, A; Read, J Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors. Bioorg Med Chem Lett20:6242-5 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ephrin type-B receptor 4 |
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Name: | Ephrin type-B receptor 4 |
Synonyms: | EPHB4 | EPHB4_HUMAN | Ephrin receptor | Ephrin type-B receptor 4 precursor (Tyrosine-protein kinase receptor HTK). | HTK | Hepatoma transmembrane kinase | MYK1 | TYRO11 | Tyrosine-protein kinase TYRO11 | VHL/Ephrin type-B receptor 4 |
Type: | Enzyme |
Mol. Mass.: | 108273.51 |
Organism: | Homo sapiens (Human) |
Description: | P54760 |
Residue: | 987 |
Sequence: | MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEV
CDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDA
DTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQD
QGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCR
EDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSA
VCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALR
CRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPV
PFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPS
SVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLAL
IAGTAVVGVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHGTKVYIDPFTYEDPN
EAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRRE
FLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGM
LRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGG
KIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLP
PPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLD
QRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKK
ILASVQHMKSQAKPGTPGGTGGPAPQY
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BDBM50329055 |
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n/a |
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Name | BDBM50329055 |
Synonyms: | CHEMBL1270671 | N4-(benzofuran-7-yl)-N2-(3-(methylsulfonyl)phenyl)pyrimidine-2,4-diamine |
Type | Small organic molecule |
Emp. Form. | C19H16N4O3S |
Mol. Mass. | 380.42 |
SMILES | CS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4ccoc34)n2)c1 |
Structure |
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