Reaction Details |
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Target | Renin |
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Ligand | BDBM17950 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_853461 (CHEMBL2155358) |
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IC50 | 8±n/a nM |
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Citation | Nakamura, Y; Fujimoto, T; Ogawa, Y; Sugita, C; Miyazaki, S; Tamaki, K; Takahashi, M; Matsui, Y; Nagayama, T; Manabe, K; Mizuno, M; Masubuchi, N; Chiba, K; Nishi, T Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. ACS Med Chem Lett3:754-758 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_MACFA |
Type: | PROTEIN |
Mol. Mass.: | 45012.96 |
Organism: | Macaca fascicularis |
Description: | ChEMBL_979177 |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLALGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNILSQGVLKEDVFSFYYNRDSENAQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM17950 |
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n/a |
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Name | BDBM17950 |
Synonyms: | (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide | ALISKIREN FUMARATE | Aliskiren | Aliskiren Hemifumarate | CHEMBL1639 | Rasilez | TEKTURNA |
Type | Small organic molecule |
Emp. Form. | C30H53N3O6 |
Mol. Mass. | 551.7583 |
SMILES | COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)ccc1OC |r| |
Structure |
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