Reaction Details |
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Target | Glucose-6-phosphate dehydrogenase |
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Ligand | BDBM50396489 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_862647 (CHEMBL2174120) |
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IC50 | 900±n/a nM |
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Citation | Preuss, J; Maloney, P; Peddibhotla, S; Hedrick, MP; Hershberger, P; Gosalia, P; Milewski, M; Li, YL; Sugarman, E; Hood, B; Suyama, E; Nguyen, K; Vasile, S; Sergienko, E; Mangravita-Novo, A; Vicchiarelli, M; McAnally, D; Smith, LH; Roth, GP; Diwan, J; Chung, TD; Jortzik, E; Rahlfs, S; Becker, K; Pinkerton, AB; Bode, L Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro. J Med Chem55:7262-72 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glucose-6-phosphate dehydrogenase |
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Name: | Glucose-6-phosphate dehydrogenase |
Synonyms: | Glucose-6-phosphate 1-dehydrogenase | PFG6PD |
Type: | PROTEIN |
Mol. Mass.: | 86360.63 |
Organism: | Plasmodium falciparum |
Description: | ChEMBL_862647 |
Residue: | 736 |
Sequence: | MNNYQNNYIYNEKTLDFINNDQDNDNLKYLKEYVYFTTTNQFDVRKRITVSLNLLANASS
KIFLLNSKDKLDLWKNMLIKSYIEVNYNLYPATYLIDTSCTNENVNINNNNNNNNKNKNN
YCYSNTTVISCGYENYTKYIEEIYDSKYALSLYSNSLNKEELLTIIIFGCSGDLAKKKIY
PALFKLFCNNSLPKDLLIIGFARTVQDFDTFFDKIVIYLKRCLLCYEDWSISKKKDLLNG
FKNRCRYFVGNYSSSESFENFNKYLTTIEEEEAKKKYYATCYKMNGSDYNISNNVAEDNI
SIDDENKTNEYFQMCTPKNCPDNVFSSNYNFPYVINSILYLALPPHIFISTLKKIIKKNC
LNSKGTDKILLEKPFGNDLDSFKMLSKQILENFNEQQIYRIDHYLGKDMVSGLLKLKFTN
TFLLSLMNRHFIKCIKITLKETKGVYGRGQYFDPYGIIRDVMQNHMLQLLTLITMEDPID
LNDESVKNEKIKILKSIPSIKLEDTIIGQYEKAENFKEDENNDDESKKNHSYHDDPHIDK
NSITPTFCTCILYINSINWYGVPIIFKSGKGLNKDICEIRIQFHNIMGSSDENMNNNEFV
IILQPVEAIYLKMMIKKTGCEEMEEVQLNLTVNEKNKKINVPEAYETLLLECFKGHKKKF
ISDEELYESWRIFTPLLKELQEKQVKPLKYSFGSSGPKEVFGLVKKYYNYGKNYTHRPEF
VRKSSFYEDDLLDINY
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BDBM50396489 |
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n/a |
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Name | BDBM50396489 |
Synonyms: | CHEMBL2170943 |
Type | Small organic molecule |
Emp. Form. | C23H24FN3O2S |
Mol. Mass. | 425.519 |
SMILES | CCN1CCC[C@@H]1CNC(=O)c1ccc2S\C(=C/c3ccccc3F)C(=O)Nc2c1 |r| |
Structure |
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