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TargetNT-3 growth factor receptor
LigandBDBM50092085
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1498687
IC50 3.0±n/a nM
Citation Choi HSRucker PVWang ZFan YAlbaugh PChopiuk GGessier FSun FAdrian FLiu GHood TLi NJia YChe JMcCormack SLi ALi JSteffy ACulazzo ATompkins CPhung VKreusch ALu MHu BChaudhary APrashad MTuntland TLiu BHarris JSeidel HMLoren JMolteni V (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors. ACS Med Chem Lett 6:562-7 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NT-3 growth factor receptor
Name:Neurotrophic tyrosine kinase receptor
Synonyms:GP145-TrkC | Neurotrophic tyrosine kinase receptor type 3 | Trk-C | TrkC tyrosine kinase | Tyrosine kinase receptor C (Trk-C)
Type:Enzyme
Mol. Mass.:94428.15
Organism:Homo sapiens (Human)
Description:Q16288
Residue:839
Sequence:
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL
KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI
VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA
SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF
CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI
ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
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  Blast E-value cutoff:
BDBM50092085
n/a
NameBDBM50092085
Synonyms:CHEMBL3582438
TypeSmall organic molecule
Emp. Form.C23H18FN5
Mol. Mass.383.4209
SMILESFc1cccc(c1)[C@H]1CCCN1c1ccc2ncc(-c3ccc(cc3)C#N)n2n1 |r|
Structure
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