| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fgr |
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| Ligand | BDBM50092081 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1498712 (CHEMBL3583125) |
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| IC50 | 5900±n/a nM |
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| Citation |  Choi, HS; Rucker, PV; Wang, Z; Fan, Y; Albaugh, P; Chopiuk, G; Gessier, F; Sun, F; Adrian, F; Liu, G; Hood, T; Li, N; Jia, Y; Che, J; McCormack, S; Li, A; Li, J; Steffy, A; Culazzo, A; Tompkins, C; Phung, V; Kreusch, A; Lu, M; Hu, B; Chaudhary, A; Prashad, M; Tuntland, T; Liu, B; Harris, J; Seidel, HM; Loren, J; Molteni, V (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors. ACS Med Chem Lett6:562-7 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Fgr |
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| Name: | Tyrosine-protein kinase Fgr |
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| Synonyms: | FGR | FGR_HUMAN | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC | SRC2 | p55-Fgr | p58-Fgr | p58c-Fgr |
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| Type: | protein |
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| Mol. Mass.: | 59469.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09769 |
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| Residue: | 529 |
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| Sequence: | MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA
INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL
SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY
SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP
CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP
KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV
DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF
PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP
PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
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| BDBM50092081 |
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| n/a |
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| Name | BDBM50092081 |
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| Synonyms: | CHEMBL3582442 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27FN6O |
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| Mol. Mass. | 458.5306 |
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| SMILES | OC1CCN(CC1)c1cc(ccn1)-c1cnc2ccc(nn12)N1CCC[C@@H]1c1cccc(F)c1 |r| |
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| Structure | 
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