| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lyn |
|---|
| Ligand | BDBM50092079 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1498722 (CHEMBL3583135) |
|---|
| IC50 | 6400±n/a nM |
|---|
| Citation |  Choi, HS; Rucker, PV; Wang, Z; Fan, Y; Albaugh, P; Chopiuk, G; Gessier, F; Sun, F; Adrian, F; Liu, G; Hood, T; Li, N; Jia, Y; Che, J; McCormack, S; Li, A; Li, J; Steffy, A; Culazzo, A; Tompkins, C; Phung, V; Kreusch, A; Lu, M; Hu, B; Chaudhary, A; Prashad, M; Tuntland, T; Liu, B; Harris, J; Seidel, HM; Loren, J; Molteni, V (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors. ACS Med Chem Lett6:562-7 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Lyn |
|---|
| Name: | Tyrosine-protein kinase Lyn |
|---|
| Synonyms: | JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 58575.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07948 |
|---|
| Residue: | 512 |
|---|
| Sequence: | MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
|
|
|
|---|
| BDBM50092079 |
|---|
| n/a |
|---|
| Name | BDBM50092079 |
|---|
| Synonyms: | CHEMBL3582439 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18FN5 |
|---|
| Mol. Mass. | 359.3995 |
|---|
| SMILES | Fc1cccc(c1)[C@H]1CCCN1c1ccc2ncc(-c3ccccn3)n2n1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
