Ki Summary

Reaction Details

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Target

Inward rectifier potassium channel 13

Ligand

BDBM155928

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1515522 (CHEMBL3615703)

IC50

>10000±n/a nM

Citation

Walsh, SP; Shahripour, A; Tang, H; Teumelsan, N; Frie, J; Zhu, Y; Priest, BT; Swensen, AM; Liu, J; Margulis, M; Visconti, R; Weinglass, A; Felix, JP; Brochu, RM; Bailey, T; Thomas-Fowlkes, B; Alonso-Galicia, M; Zhou, X; Pai, LY; Corona, A; Hampton, C; Hernandez, M; Bentley, R; Chen, J; Shah, K; Metzger, J; Forrest, M; Owens, K; Tong, V; Ha, S; Roy, S; Kaczorowski, GJ; Yang, L; Parmee, E; Garcia, ML; Sullivan, K; Pasternak, A Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation. ACS Med Chem Lett6:747-52 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Inward rectifier potassium channel 13

Name:

Inward rectifier potassium channel 13

Synonyms:

Inward rectifier K(+) channel Kir7.1 | KCJ13_HUMAN | KCNJ13 | Potassium channel, inwardly rectifying subfamily J member 13

Type:

PROTEIN

Mol. Mass.:

40527.12

Organism:

Homo sapiens (Human)

Description:

ChEMBL_105176

Residue:

360

Sequence:

MDSSNCKVIAPLLSQRYRRMVTKDGHSTLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVF
SASFVVHWLVFAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTI
GYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAH
MDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGKLYQTSVDFHLDGISSDECPFFIFP
LTYYHSITPSSPLATLLQHENPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHCFA
SLLTRGSKGEYQIKMENFDKTVPEFPTPLVSKSPNRTDLDIHINGQSIDNFQISETGLTE

BDBM155928

n/a

Name

BDBM155928

Synonyms:

US9018211, 52

Type

Small organic molecule

Emp. Form.

C24H28N4O5

Mol. Mass.

452.5029

SMILES

COc1cc(ncc1C#N)[C@@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1 |r|

Structure