| Reaction Details |
|---|
 | Report a problem with these data |
| Target | N-lysine methyltransferase SMYD2 |
|---|
| Ligand | BDBM50180978 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1585280 |
|---|
| IC50 | 6000±n/a nM |
|---|
| Citation |  Eggert, E; Hillig, RC; Koehr, S; Stöckigt, D; Weiske, J; Barak, N; Mowat, J; Brumby, T; Christ, CD; Ter Laak, A; Lang, T; Fernandez-Montalvan, AE; Badock, V; Weinmann, H; Hartung, IV; Barsyte-Lovejoy, D; Szewczyk, M; Kennedy, S; Li, F; Vedadi, M; Brown, PJ; Santhakumar, V; Arrowsmith, CH; Stellfeld, T; Stresemann, C Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem59:4578-600 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| N-lysine methyltransferase SMYD2 |
|---|
| Name: | N-lysine methyltransferase SMYD2 |
|---|
| Synonyms: | HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49689.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NRG4 |
|---|
| Residue: | 433 |
|---|
| Sequence: | MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE
GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP
ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVN
CNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY
IDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGAL
QYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDH
PYISEIKQEIESH
|
|
|
|---|
| BDBM50180978 |
|---|
| n/a |
|---|
| Name | BDBM50180978 |
|---|
| Synonyms: | CHEMBL3819515 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18ClF2N7O2 |
|---|
| Mol. Mass. | 473.863 |
|---|
| SMILES | FC(F)Oc1cccc(N\C(=N\C#N)N2CC(N3CNCC3=O)C(=N2)c2ccc(Cl)cc2)c1 |c:24| |
|---|
| Structure | 
|
|---|
Search and Browse
