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TargetN-lysine methyltransferase SMYD2
LigandBDBM50180955
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1585277
IC50 27±n/a nM
Citation Eggert EHillig RCKoehr SStöckigt DWeiske JBarak NMowat JBrumby TChrist CDTer Laak ALang TFernandez-Montalvan AEBadock VWeinmann HHartung IVBarsyte-Lovejoy DSzewczyk MKennedy SLi FVedadi MBrown PJSanthakumar VArrowsmith CHStellfeld TStresemann C Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem 59:4578-600 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
N-lysine methyltransferase SMYD2
Name:N-lysine methyltransferase SMYD2
Synonyms:HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SMYD2
Type:Enzyme
Mol. Mass.:49689.57
Organism:Homo sapiens (Human)
Description:Q9NRG4
Residue:433
Sequence:
MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE
GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP
ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVN
CNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY
IDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGAL
QYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDH
PYISEIKQEIESH
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  Blast E-value cutoff:
BDBM50180955
n/a
NameBDBM50180955
Synonyms:CHEMBL3818617
TypeSmall organic molecule
Emp. Form.C22H20Cl2F2N6O3
Mol. Mass.525.335
SMILESCCN([C@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\Nc1cccc(OC(F)F)c1)=N/C#N)C(=O)CO |r,c:6|
Structure
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