| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 8 [30-404] |
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| Ligand | BDBM225230 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HMT Assay |
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| IC50 | >1.0e+4±n/a nM |
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| Citation |  Qi, W; Zhao, K; Gu, J; Huang, Y; Wang, Y; Zhang, H; Zhang, M; Zhang, J; Yu, Z; Li, L; Teng, L; Chuai, S; Zhang, C; Zhao, M; Chan, H; Chen, Z; Fang, D; Fei, Q; Feng, L; Feng, L; Gao, Y; Ge, H; Ge, X; Li, G; Lingel, A; Lin, Y; Liu, Y; Luo, F; Shi, M; Wang, L; Wang, Z; Yu, Y; Zeng, J; Zeng, C; Zhang, L; Zhang, Q; Zhou, S; Oyang, C; Atadja, P; Li, E An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. Nat Chem Biol13:381-388 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 8 [30-404] |
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| Name: | Mitogen-activated protein kinase kinase kinase 8 [30-404] |
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| Synonyms: | COT | ESTF | M3K8_HUMAN | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) |
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| Type: | Protein |
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| Mol. Mass.: | 42506.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human MAP3K8 truncation (30-404 aa) |
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| Residue: | 375 |
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| Sequence: | MENLYASEEPAVYEPSLMTMCQDSNQNDERSKSLLLSGQEVPWLSSVRYGTVEDLLAFAN
HISNTAKHFYGQRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAF
GKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEA
GEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLV
DFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVK
RYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALN
PPREDQPRCQSLDSA
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| BDBM225230 |
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| n/a |
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| Name | BDBM225230 |
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| Synonyms: | EED226 | US11013745, Compound EED226 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15N5O3S |
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| Mol. Mass. | 369.398 |
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| SMILES | CS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2ccco2)n2cnnc12 |
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| Structure | 
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