Reaction Details | |||
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Target | Non-receptor tyrosine-protein kinase TYK2 | ||
Ligand | BDBM325507 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Tyk2 Inhibition Assay | ||
IC50 | 55±n/a nM | ||
Citation | Allen, S; Boys, ML; Chicarelli, MJ; Fell, JB; Fischer, JP; Gaudino, J; Hicken, EJ; Hinklin, RJ; Kraser, CF; Laird, E; Robinson, JE; Tang, TP; Burgess, LE; Rieger, RA; Pheneger, J; Satoh, Y; Leftheris, K; Raheja, RK; Bennett, BL 4,6-substituted-pyrazolo[1,5-a]pyrazines as Janus kinase inhibitors US Patent US10730880 Publication Date 8/4/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Non-receptor tyrosine-protein kinase TYK2 | |||
Name: | Non-receptor tyrosine-protein kinase TYK2 | ||
Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (TYK2) | TYK2 | TYK2_HUMAN | Tyrosine-protein kinase TYK2 | ||
Type: | Protein | ||
Mol. Mass.: | 133666.03 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P29597 | ||
Residue: | 1187 | ||
Sequence: |
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BDBM325507 | |||
n/a | |||
Name | BDBM325507 | ||
Synonyms: | (1r,3r)-N,N-dimethyl-3-(4- (4-(1-(pentan-3-yl)-1H- pyrazol-4-yl)pyrazolo[1,5- a]pyrazin-6-yl)-1H- pyrazol-1- yl)cyclobutanecarboxamide | US10189845, Example 169 | US10189845, Example 170 | US10730880, Example 169 | US11028093, Example 170 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H30N8O | ||
Mol. Mass. | 446.548 | ||
SMILES | CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@@H](C1)C(=O)N(C)C |r,wU:26.32,(-.02,5.16,;-1.1,4.07,;-2.59,4.47,;-2.99,5.96,;-1.9,7.05,;-3.68,3.38,;-3.2,1.92,;-4.45,1.01,;-5.7,1.92,;-5.22,3.38,;-4.45,-.53,;-3.12,-1.3,;-3.12,-2.84,;-4.45,-3.61,;-5.78,-2.84,;-7.25,-3.31,;-8.15,-2.07,;-7.25,-.82,;-5.78,-1.3,;-1.78,-3.61,;-1.78,-5.15,;-.32,-5.62,;.59,-4.38,;-.32,-3.13,;2.13,-4.38,;3.22,-5.47,;4.3,-4.38,;3.22,-3.29,;5.84,-4.38,;6.61,-3.05,;6.61,-5.71,;5.84,-7.05,;8.15,-5.71,)| | ||
Structure |