265 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28213282	57	Design, synthesis and biological evaluation of thienopyrimidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.	Chinese Academy of Sciences
28109947	424	Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitors.	Washington University
28337317	30	Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity.	Wayne State University
28057407	76	Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.	Georgia Institute of Technology
27717544	75	Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors.	Integral Biosciences
27665180	14	Design and synthesis of novel HDAC8 inhibitory 2,5-disubstituted-1,3,4-oxadiazoles containing glycine and alanine hybrids with anti cancer activity.	Acharya Nagarjuna University
27606546	218	Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.	University of Navarra
27377864	55	Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.	Broad Institute of Mit and Harvard
27190592	24	Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs.	Irbm Science Park
27177826	2	Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.	Yale University
26443078	108	Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.	Sichuan University
26890114	56	Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.	Shanghai Institute of Materia Medica
26681404	40	Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors.	Washington University
26814680	71	Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.	Shenyang Pharmaceutical University
26804233	38	Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.	Massachusetts General Hospital
26706171	138	Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.	Shenyang Pharmaceutical University
26689485	18	Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.	Orchid Chemicals & Pharmaceuticals
26629860	58	Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.	European Institute of Oncology
26753813	22	Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.	University of Minnesota
26331334	99	Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.	Guangzhou Institute of Biomedicine and Health
26086931	38	Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.	Shandong University
26264503	46	Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.	University of Minnesota
26211462	71	Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors.	The Walter and Eliza Hall Institute of Medical Research
25637120	94	Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).	St. Jude Children'S Research Hospital
22344701	30	Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).	Novartis Institutes For Biomedical Research
25147612	25	Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.	University of Florida
25261927	80	Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors.	The Walter and Eliza Hall Institute of Medical Research
26054247	48	Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.	Colorado State University
26100440	6	Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitors.	Shandong University
25974739	17	Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release.	University of California
25906087	14	Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.	Shandong University
25905694	24	Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.	Istituto Ortopedico Rizzoli (Ior)
25805446	30	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.	East China Normal University
25070421	33	Evaluation of class I HDAC isoform selectivity of largazole analogues.	Duke University
25042254	7	Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.	H�Pital Kirchberg
24864038	112	Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors.	Nippon Pharmaceutical Chemicals
25563890	49	Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.	R&D Sigma-Tau Industrie Farmaceutiche Riunite
25462271	33	Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.	Shandong University
25454270	82	Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.	TBA
25380299	61	Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles.	Technical University of Denmark
25238284	52	Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.	Roche Pharmaceutical Research and Early Development
25233084	247	ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.	R&D Sigma-Tau Industrie Farmaceutiche Riunite
25218912	103	Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.	Chinese Academy of Sciences
24944733	101	Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors.	Chinese National Center For Drug Screening
24900838	30	Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.	Merck Research Laboratories
24742384	90	Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.	Universit£
24694055	35	Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.	Shandong University
24261862	23	Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.	Biofocus
24328302	94	Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.	Heinrich-Heine-Universit£T D£Sseldorf
24095018	24	The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase.	East China Normal University
24035339	4	Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.	Colorado State University
23964961	9	Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform.	Millennium Pharmaceuticals
23627282	10	Development and therapeutic implications of selective histone deacetylase 6 inhibitors.	University of Illinois At Chicago
23906422	1	Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents.	Translational Drug Development
24015327	42	Development of a chimeric c-Src kinase and HDAC inhibitor.	University of Michigan
23644210	5	Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors.	Congenia
23602523	5	The discovery of colchicine-SAHA hybrids as a new class of antitumor agents.	East China Normal University
23591111	2	A cyclodextrin-capped histone deacetylase inhibitor.	University of Sussex
23672185	3	Discovery of the first histone deacetylase 6/8 dual inhibitors.	Broad Institute of Mit and Harvard
23368884	80	Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.	Broad Institute of Mit and Harvard
23493449	8	Development of	Shandong University
24900575	31	Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry.	Chinese Academy of Sciences
23089527	6	The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.	Wayne State University
23061376	63	Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.	Roche R & D Center China
23009203	39	Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.	University of Illinois At Chicago
23010266	24	Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.	University of Illinois At Chicago
22642300	160	Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.	Kyoto Prefectural University of Medicine
22738629	47	CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design.	Chinese Academy of Sciences
22541394	30	Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.	Guru Ghasidas University
21874153	54	Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.	Broad Institute of Harvard and Mit
20472442	25	On the inhibition of histone deacetylase 8.	University of Notre Dame
20452225	49	Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.	Mcgill University
19705846	100	Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.	The Scripps Research Institute
18809328	64	Optimization of a series of potent and selective ketone histone deacetylase inhibitors.	Irbm/Merck Research Laboratories
17956988	14	Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.	Istituto Di Ricerche Di Biologia Molecolare
18182289	127	Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).	Merck Research Laboratories
18247554	134	Histone deacetylase inhibitors: from bench to clinic.	Menarini Ricerche
16987657	45	A series of novel, potent, and selective histone deacetylase inhibitors.	Irbm/Merck Research Laboratories
21417419	5	Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.	Dac
21721525	8	In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).	Harvard Medical School
21889343	6	The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity.	Wayne State University
21634430	218	Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.	S*Bio
21745740	10	Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors.	East China Normal University
21696956	243	A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.	Broad Institute of Harvard and Mit
21080647	27	Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor.	Chroma Therapeutics
21417297	220	Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.	Universita` Degli Studi Di Siena
21256006	11	Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors.	Yonsei University
21145737	12	Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy.	Roche R & D Center China
21073160	143	Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity	TBA
21080629	153	Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.	University of Regensburg
19966789	40	Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.	The Scripps Research Institute
20637529	15	Design and synthesis of novel isoxazole-based HDAC inhibitors.	Università
20223566	23	Inside HDAC with HDAC inhibitors.	Universit£
20451378	107	Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.	S*Bio
20381359	17	Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222.	Universit£
20205394	44	Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).	Novartis Institutes For Biomedical Research
20143840	28	Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring.	Umr Cnrs 6026-Universit£
20055418	78	Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.	University of Illinois At Chicago
20143778	70	Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.	Curis
19906529	22	Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.	Ortho-Biotech Oncology Research & Development
19359173	51	Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.	Sigma-Tau Research and Development
19362838	16	Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors.	The Scripps Research Institute
19441846	35	Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.	Irbm/Merck Research Laboratories
19419863	58	Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.	University of Illinois At Chicago
19410459	33	Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.	Irbm/Merck Research Laboratories
19285395	66	N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.	R&D Sigma-Tau
19268585	30	Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).	Merck Research Laboratories
19181524	46	N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.	S*Bio
19114304	44	SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).	Methylgene
18952417	50	Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors.	Irbm-Merck Research Laboratories Rome
18951790	109	SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).	Merck Research Laboratories
18930398	117	2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.	Irbm-Merck Research Laboratories Rome
18672316	41	Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.	Institute of Organic Synthesis
18642892	76	Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.	University of Illinois At Chicago
18060775	67	Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).	Merck Research Laboratories
17761416	53	The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.	Merck Research Laboratories
17691763	20	2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.	University of Regensburg
17606370	2	Trithiocarbonates: exploration of a new head group for HDAC inhibitors.	Altana Pharma
17555962	26	Design of novel histone deacetylase inhibitors.	Merck Research Laboratories
32113841	19	Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors.	Irbm
32787077	23	Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.	Sichuan University
32631504	29	Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors.	Sichuan University
32331932	180	Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.	Merck
32470298	42	-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting	Helmholtz Institute For Pharmaceutical Research Saarland (Hips) - Helmholtz Centre For Infection Research (Hzi
32247729	23	Environment-sensitive fluorescent inhibitors of histone deacetylase.	Shandong University
32672458	164	Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting.	University of Toronto Mississauga
32435414	24	Design of First-in-Class Dual EZH2/HDAC Inhibitor: Biochemical Activity and Biological Evaluation in Cancer Cells.	Sapienza University of Rome
32383881	93	Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation.	The University of Queensland
27774131	32	Development of a Potent and Selective HDAC8 Inhibitor.	Boston University
30597327	32	A novel class of anthraquinone-based HDAC6 inhibitors.	Keimyung University
30245394	363	HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors.	Indian Csir-Central Drug Research Institute
30629434	64	Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy.	TBA
31630054	335	Synthesis and structure activity relationship of 1, 3-benzo-thiazine-2-thiones as selective HDAC8 inhibitors.	University of Applied Sciences
32212730	206	Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors.	National Center For Advancing Translational Sciences
30776234	32	Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.	University of Toronto Mississauga
30735902	69	Histone deacetylase 3 inhibitors in learning and memory processes with special emphasis on benzamides.	Jadavpur University
31223439	25	Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling.	Umr Cnrs 7285
30802729	29	Design, synthesis and biological evaluation of novel isoindolinone derivatives as potent histone deacetylase inhibitors.	Northwest A&F University
30476825	37	1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase.	Taipei Medical University
31120744	17	Hydroxamic Acid Derivatives of ?-Carboline/Hydroxycinnamic Acid Hybrids Inducing Apoptosis and Autophagy through the PI3K/Akt/mTOR Pathways.	Nantong University
31938464	93	Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.	University of Toronto Mississauga
31655430	56	N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-? induced PD-L1 expression.	Taipei Medical University
31561937	32	Recent advances in class IIa histone deacetylases research.	Heinrich-Heine-Universit£T D£Sseldorf
31306905	42	Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors.	Fudan University
31855601	73	Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors.	Chinese Academy of Sciences
32321249	138	Design of Hydrazide-Bearing HDACIs Based on Panobinostat and Their p53 and FLT3-ITD Dependency in Antileukemia Activity.	Ocean University of China
32267687	37	Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma.	Shandong University
32153186	118	Discovery of Thieno[2,3-	Sichuan University and Collaborative Innovation Center of Biotherapy
31536895	27	Indole: A privileged scaffold for the design of anti-cancer agents.	Hunan University of Science and Technology
30851694	33	?-Carboline and N-hydroxycinnamamide hybrids as anticancer agents for drug-resistant hepatocellular carcinoma.	Nantong University
30418766	35	Kinase and Histone Deacetylase Hybrid Inhibitors for Cancer Therapy.	Qingdao University
30482621	4	Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro.	Irbm Science Park
31415174	44	Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases.	University of Naples Federico Ii
31050421	48	Overview of Recent Strategic Advances in Medicinal Chemistry.	Shandong University
31627059	29	Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.	National University of Singapore
31413795	57	Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors.	Shandong University
26611919	21	Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates.	University of Geneva
26613635	23	Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids.	Mcgill University
30179749	30	HDAC3 is a potential validated target for cancer: An overview on the benzamide-based selective HDAC3 inhibitors through comparative SAR/QSAR/QAAR approaches.	Jadavpur University
30385227	22	Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimer's disease.	Sun Yat-Sen University
29670692	29	Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors.	East China University of Science and Technology
29289885	9	Structural and biological characterization of new hybrid drugs joining an HDAC inhibitor to different NO-donors.	Goethe University
29288941	25	Development of novel ?-carboline-based hydroxamate derivatives as HDAC inhibitors with antiproliferative and antimetastatic activities in human cancer cells.	Nantong University
29150330	54	The structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity.	Wayne State University
30122227	113	Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.	Nestle Skin Health R&D
30115492	47	A series of camptothecin prodrugs exhibit HDAC inhibition activity.	East China Normal University
29567459	49	1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC.	Taipei Medical University
30028616	101	5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes.	Taipei Medical University
29549837	151	Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.	University of Navarra
29787262	64	Discovery of Novel Pazopanib-Based HDAC and VEGFR Dual Inhibitors Targeting Cancer Epigenetics and Angiogenesis Simultaneously.	Shandong University
30045621	55	Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents.	East China University of Science and Technology
29454918	12	Design, synthesis, and biological evaluation of novel amide and hydrazide based thioether analogs targeting Histone deacteylase (HDAC) enzymes.	Ahram Canadian University
29776742	55	Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11.	Forma Therapeutics
28648462	47	Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells.	The Scripps Research Institute
28648461	20	The structural requirements of histone deacetylase inhibitors: SAHA analogs modified at the C5 position display dual HDAC6/8 selectivity.	Wayne State University
28368585	18	Exploring Derivatives of Quinazoline Alkaloid l-Vasicine as Cap Groups in the Design and Biological Mechanistic Evaluation of Novel Antitumor Histone Deacetylase Inhibitors.	Csir-Indian Institute of Integrative Medicine
27886544	46	3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity.	Taipei Medical University
28771357	50	Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD).	Universit£
28511906	18	Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups.	Shandong University
28453994	118	Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors.	Ghent University
28549219	30	Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.	Novartis Institutes For Biomedical Research
28415009	51	Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study.	Shandong University
28336407	8	Development of N-hydroxycinnamamide-based HDAC inhibitors with improved HDAC inhibitory activity and in vitro antitumor activity.	Shandong University
28196613	34	Potent and Selective EphA4 Agonists for the Treatment of ALS.	Sanford Burnham Prebys Medical Discovery Institute
8437101	20	Expression and characterization of the rat D3 dopamine receptor: pharmacologic properties and development of antibodies.	University of Pennsylvania
1586393	43	Localization and function of the D3 dopamine receptor.	U. 109
1554381	19	Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase.	National Institutes of Diabetes and Digestive and Kidney Diseases
1501121	12	Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist.	Sanofi Recherche
282646	50	Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine.	TBA
37098	14	Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors.	TBA
18291323	20	Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites.	University of Amsterdam
17825569	48	The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.	Polish Academy of Sciences