The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28040393 |
7 |
Synthesis and biological evaluation of naphthoquinone-coumarin conjugates as topoisomerase II inhibitors.![EBI](/images/logo_chembl.png) |
Instituto Universitario De Bio-Org£Nica (Cibican) |
27521587 |
20 |
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIa, G-quadruplex binding and cytotoxic properties.![EBI](/images/logo_chembl.png) |
Universit£ |
26906637 |
2 |
Inhibition of human DNA topoisomerase IIa by two novel ellipticine derivatives.![EBI](/images/logo_chembl.png) |
Vanderbilt University School of Medicine |
26649766 |
2 |
Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors.![EBI](/images/logo_chembl.png) |
Sun Yat-Sen University |
25799376 |
2 |
Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents.![EBI](/images/logo_chembl.png) |
Taipei Medical University |
26216018 |
2 |
Imine/amide-imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole: Microwave-assisted synthesis and anticancer activity via selective topoisomerase-II-a inhibition.![EBI](/images/logo_chembl.png) |
Central University of Punjab |
26183545 |
47 |
4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIa targeting the ATP binding site.![EBI](/images/logo_chembl.png) |
National Institute of Chemistry |
25286019 |
18 |
Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization.![EBI](/images/logo_chembl.png) |
Astrazeneca |
25941559 |
1 |
Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIa Catalytic Inhibitors.![EBI](/images/logo_chembl.png) |
National Institute of Pharmaceutical Education and Research (NIPER) |
25453816 |
27 |
Monocyclic 4-amino-6-(phenylamino)-1,3,5-triazines as inhibitors of human DNA topoisomerase IIa.![EBI](/images/logo_chembl.png) |
National Institute of Chemistry |
15808469 |
32 |
Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure-activity relationships.![EBI](/images/logo_chembl.png) |
Kumamoto University |
23092389 |
5 |
Lanostanoids from fungi: a group of potential anticancer compounds.![EBI](/images/logo_chembl.png) |
TBA |
22483608 |
2 |
Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl)acetohydrazide derivatives as antitumor agents.![EBI](/images/logo_chembl.png) |
Sichuan University |
20371180 |
122 |
Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.![EBI](/images/logo_chembl.png) |
Stephen F. Austin State University |
20006518 |
2 |
A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II.![EBI](/images/logo_chembl.png) |
University of Manitoba |
11754608 |
6 |
Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity.![EBI](/images/logo_chembl.png) |
Osaka University of Pharmaceutical Sciences |
18321715 |
15 |
Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition.![EBI](/images/logo_chembl.png) |
Ewha Womans University |
18077363 |
314 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.![EBI](/images/logo_chembl.png) |
University of Oxford |
18083028 |
5 |
Synthesis and biological evaluation of bengacarboline derivatives.![EBI](/images/logo_chembl.png) |
Universit£ |
8765520 |
3 |
Design, synthesis, and biological evaluation of ellipticine-estradiol conjugates.![EBI](/images/logo_chembl.png) |
Purdue University |
22014228 |
10 |
Catalytic inhibition of eukaryotic topoisomerases I and II by flavonol glycosides extracted from Vicia faba and Lotus edulis.![EBI](/images/logo_chembl.png) |
University of Thessaly |
22014547 |
2 |
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.![EBI](/images/logo_chembl.png) |
University of Cagliari |
21644529 |
2 |
N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIa and induce apoptosis in G1/S phase.![EBI](/images/logo_chembl.png) |
National Institute of Pharmaceutical Education and Research (NIPER) |
21600681 |
4 |
Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.![EBI](/images/logo_chembl.png) |
Sun Yat-Sen University |
21391686 |
12 |
Role of metalation in the topoisomerase IIa inhibition and antiproliferation activity of a series ofa-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes.![EBI](/images/logo_chembl.png) |
Memorial Sloan-Kettering Cancer Center |
20353152 |
1 |
A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.![EBI](/images/logo_chembl.png) |
Chinese Academy of Sciences |
19595598 |
2 |
7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents.![EBI](/images/logo_chembl.png) |
Universit£ |
19457675 |
8 |
The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds.![EBI](/images/logo_chembl.png) |
University of Manitoba |
19560355 |
2 |
Discovery of a new class of catalytic topoisomerase II inhibitors targeting the ATP-binding site by structure based design. Part I.![EBI](/images/logo_chembl.png) |
Novartis Institutes For Biomedical Research |
19364657 |
11 |
Synthesis, cytotoxic activity, DNA topoisomerase-II inhibition, molecular modeling and structure-activity relationship of 9-anilinothiazolo[5,4-b]quinoline derivatives.![EBI](/images/logo_chembl.png) |
Universidad Nacional AutóNoma De MéXico |
18258442 |
9 |
The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds.![EBI](/images/logo_chembl.png) |
University of Manitoba |
12444693 |
5 |
Triterpenoid constituents isolated from the bark of Abies sachalinensis.![EBI](/images/logo_chembl.png) |
Osaka University of Pharmaceutical Sciences |
11678653 |
1 |
Catalytic inhibition of topoisomerase IIalpha by demethylzeylasterone, a 6-oxophenolic triterpenoid from Kokoona zeylanica.![EBI](/images/logo_chembl.png) |
University of Arizona |
11430001 |
72 |
Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.![EBI](/images/logo_chembl.png) |
Kumamoto University |
10757727 |
2 |
Three new triterpenoids from Peganum nigellastrum.![EBI](/images/logo_chembl.png) |
Toho University |
9544566 |
1 |
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia.![EBI](/images/logo_chembl.png) |
Ohio State University |
15149679 |
6 |
Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs.![EBI](/images/logo_chembl.png) |
University of Maryland |
32527548 |
7 |
Synthesis and evaluation of novel sulfonamide analogues of 6/7-aminoflavones as anticancer agents via topoisomerase II inhibition.![EBI](/images/logo_chembl.png) |
Prof John Barnabas Post Graduate School of Biological Studies |
31096154 |
39 |
Structure-guided optimization of 4,6-substituted-1,3,5-triazin-2(1H)-ones as catalytic inhibitors of human DNA topoisomerase II?.![EBI](/images/logo_chembl.png) |
Slovenia |
29870668 |
8 |
Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.![EBI](/images/logo_chembl.png) |
Shandong University |
31494471 |
15 |
Natural dimers of coumarin, chalcones, and resveratrol and the link between structure and pharmacology.![EBI](/images/logo_chembl.png) |
Nagasaki International University |
30959322 |
47 |
Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone.![EBI](/images/logo_chembl.png) |
University of Iowa |
32196342 |
20 |
Design, Synthesis, Dynamic Docking, Biochemical Characterization, and ![EBI](/images/logo_chembl.png) |
Istituto Italiano Di Tecnologia |
30962087 |
21 |
Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.![EBI](/images/logo_chembl.png) |
Glaxosmithkline |
31618025 |
2 |
Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.![EBI](/images/logo_chembl.png) |
European Biomedical Research Institute of Salerno (Ebris) |
31675229 |
45 |
Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.![EBI](/images/logo_chembl.png) |
Colorado State University |
30698430 |
32 |
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria.![EBI](/images/logo_chembl.png) |
Chinese Academy of Sciences |
28157593 |
6 |
Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains.![EBI](/images/logo_chembl.png) |
Alma Mater Studiorum-University of Bologna |
25083189 |
8 |
Selective Inhibition of Bacterial Topoisomerase I by alkynyl-bisbenzimidazoles.![EBI](/images/logo_chembl.png) |
Clemson University |
24363888 |
32 |
Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors.![EBI](/images/logo_chembl.png) |
University of Hawai'I At Hilo |
24456578 |
1 |
Isochromans and ?-pyrones from Penicillium corylophilum.![EBI](/images/logo_chembl.png) |
Carleton University |
24063907 |
14 |
Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents.![EBI](/images/logo_chembl.png) |
Universit£ |
24060488 |
6 |
Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors.![EBI](/images/logo_chembl.png) |
Virginia Commonwealth University |
24013413 |
9 |
3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase II? catalytic inhibitor with low DNA damage.![EBI](/images/logo_chembl.png) |
Ewha Womans University |
23968711 |
2 |
Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors.![EBI](/images/logo_chembl.png) |
Sun Yat-Sen University |
23920485 |
2 |
Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity.![EBI](/images/logo_chembl.png) |
National Institute of Pharmaceutical Education and Research |
7769390 |
7 |
Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships.![EBI](/images/logo_chembl.png) |
University of Illinois At Chicago |
8158166 |
2 |
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.![EBI](/images/logo_chembl.png) |
Virginia Polytechnic Institute and State University |
8383731 |
2 |
A new bastadin from the sponge Psammaplysilla purpurea.![EBI](/images/logo_chembl.png) |
University of Hawaii |
29885574 |
14 |
Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors.![EBI](/images/logo_chembl.png) |
Al-Azhar University |
29519604 |
22 |
Synthesis and biological evaluation of histone deacetylase and DNA topoisomerase II-Targeted inhibitors.![EBI](/images/logo_chembl.png) |
Kindai University |
28619446 |
13 |
Design, synthesis, and evaluation of DNA topoisomerase II-targeted nucleosides.![EBI](/images/logo_chembl.png) |
Kyoto University |
28406299 |
46 |
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.![EBI](/images/logo_chembl.png) |
Actelion Pharmaceuticals |
28919339 |
8 |
Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase II?.![EBI](/images/logo_chembl.png) |
Alma Mater Studiorum-University of Bologna |
27689733 |
11 |
Synthesis, evaluation, and CoMFA study of fluoroquinophenoxazine derivatives as bacterial topoisomerase IA inhibitors.![EBI](/images/logo_chembl.png) |
University of Hawaii At Hilo |
28462840 |
1 |
Synthesis and biological evaluation of N-(carbobenzyloxy)-l-phenylalanine and N-(carbobenzyloxy)-l-aspartic acid-?-benzyl ester derivatives as potent topoisomerase II? inhibitors.![EBI](/images/logo_chembl.png) |
Hebei University |
29077404 |
7 |
Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity.![EBI](/images/logo_chembl.png) |
Istituto Italiano Di Tecnologia |
28342691 |
9 |
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase II? inhibitors and antiproliferative agents.![EBI](/images/logo_chembl.png) |
National and Kapodistrian University of Athens |
18022567 |
34 |
Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth.![BDB](/images/logo_bindingdb.png) |
Vanderbilt University |