The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28590753 |
162 |
The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A |
Universit£ |
| 28055204 |
74 |
Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A |
Advinus Therapeutics |
| 27842891 |
75 |
A |
Advinus Therapeutics |
| 28238512 |
54 |
Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A |
Advinus Therapeutics |
| 27933962 |
89 |
Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine Derivatives: New Highly Potent A |
Universit£ |
| 27718474 |
40 |
Synthesis and evaluation of N-substituted 2-amino-4,5-diarylpyrimidines as selective adenosine A |
Leiden University |
| 27933955 |
123 |
Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships. |
RhôNe-Poulenc Rorer |
| 27227326 |
156 |
Discovery of 7-(Prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A2A Adenosine Receptor: Prediction from Molecular Modeling. |
Julius-Maximilians-Universit£T W£Rzburg |
| 27485602 |
183 |
Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors. |
Jagiellonian University Medical College |
| 27161878 |
83 |
Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors. |
Universit£ |
| 26824742 |
43 |
Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes. |
Uppsala University |
| 26756468 |
44 |
Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity. |
University of Warwick |
| 26356532 |
39 |
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions. |
Georgia Institute of Technology |
| 26781932 |
109 |
Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists. |
Merck Research Laboratories |
| 26638043 |
66 |
Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor. |
Universit£ |
| 26717203 |
129 |
5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors. |
Universit£ |
| 26046697 |
46 |
One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists. |
Universit£ |
| 25780876 |
205 |
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor. |
Universit£ |
| 25699637 |
91 |
5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists. |
University of Camerino |
| 25633494 |
128 |
A facile and novel synthesis of N(2)-, C(6)-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists. |
National University of Singapore |
| 25063944 |
56 |
7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A1 and A(2A) adenosine receptors. Molecular modeling and pharmacological studies. |
Universit£ |
| 24972108 |
256 |
Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study. |
Universit£ |
| 24164628 |
186 |
Adenosine A2A receptor as a drug discovery target. |
Merck Research Laboratories |
| 24669958 |
39 |
Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines. |
Leiden University |
| 23427825 |
45 |
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation. |
Universit£ |
| 23245803 |
87 |
Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands. |
University of Bonn |
| 23231967 |
23 |
Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold. |
University of Santiago De Compostela |
| 23171656 |
23 |
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies. |
Universita' Di Firenze |
| 20371139 |
16 |
Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists. |
Universidade De A Coru£A |
| 20382540 |
9 |
In silico directed chemical probing of the adenosine receptor family. |
Universidade Do Minho |
| 20137957 |
35 |
Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists. |
Universidade De Porto |
| 19682912 |
80 |
Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists. |
Universidade De Santiago De Compostela |
| 19346133 |
58 |
Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A(2B) receptor antagonists. |
Universidade De A Coru£A |
| 16392813 |
329 |
Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor. |
Universit£ |
| 23098605 |
248 |
Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists. |
Universit£ |
| 22827545 |
11 |
Identifying novel adenosine receptor ligands by simultaneous proteochemometric modeling of rat and human bioactivity data. |
Leiden/Amsterdam Center For Drug Research |
| 21664729 |
142 |
Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones. |
Jagiellonian University Medical College |
| 22568637 |
158 |
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. |
Universit£ |
| 22703703 |
6 |
In search for new chemical entities as adenosine receptor ligands: development of agents based on benzo-¿-pyrone skeleton. |
Universidade Do Porto |
| 22677030 |
29 |
New chromene scaffolds for adenosine A(2A) receptors: synthesis, pharmacology and structure-activity relationships. |
Universidade Do Minho |
| 22432713 |
64 |
Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists. |
Monash University |
| 24900277 |
36 |
Development of Polar Adenosine A2A Receptor Agonists for Inflammatory Bowel Disease: Synergism with A2B Antagonists. |
TBA |
| 22257095 |
65 |
3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists. |
Universit£ |
| 22220592 |
27 |
Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design. |
Heptares Therapeutics |
| 21286238 |
9 |
Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine. |
Ewha Womans University |
| 21210664 |
74 |
Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist. |
H. Lundbeck |
| 20541935 |
131 |
4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: drug-like and non-xanthine based A2B adenosine receptor antagonists. |
Roche Research Center |
| 20408530 |
98 |
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation. |
Universit£ |
| 20188574 |
141 |
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. |
University of Bonn |
| 19569717 |
251 |
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. |
Institute |
| 19282184 |
195 |
8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. |
University of Camerino |
| 18637670 |
80 |
2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. |
Leiden/Amsterdam Center For Drug Research |
| 18407496 |
127 |
Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. |
Vernalis (R&D) |
| 18321039 |
144 |
Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases. |
Cv Therapeutics |
| 18321038 |
85 |
Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 18077171 |
108 |
1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists. |
Universit£ |
| 18226909 |
162 |
1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor. |
Universit£ |
| 17933541 |
145 |
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species. |
Universit£ |
| 17927167 |
107 |
5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists. |
Universit£ |
| 17306548 |
84 |
N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor. |
Universit£ |
| 17378544 |
121 |
Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 17228880 |
76 |
Synthesis and biological evaluation of novel 1-deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide derivatives as useful templates for the development of A2B adenosine receptor agonists. |
Universit£ |
| 16487705 |
107 |
N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists. |
University of Virginia |
| 16509587 |
72 |
Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations. |
Universit£ |
| 16250647 |
71 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. |
Universit£ |
| 15771453 |
22 |
Development of spin-labeled probes for adenosine receptors. |
University of Bonn |
| 15743197 |
37 |
Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. |
Universit£ |
| 15267242 |
54 |
Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor. |
Iiqab (Csic) |
| 15876531 |
28 |
A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential. |
Novartis Institutes For Biomedical Research |
| 15084123 |
24 |
Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative. |
University of Bonn |
| 14998332 |
328 |
Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists. |
Universit£ |
| 15239649 |
24 |
New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine. |
University of Leiden |
| 12646033 |
124 |
Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists. |
Universit£ |
| 12109910 |
8 |
N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. |
Universit£ |
| 11262085 |
92 |
Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists. |
Vrije Universiteit |
| 10841798 |
64 |
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists. |
National Institute of Diabetes |
| 10212124 |
26 |
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors. |
Leiden University |
| 11459663 |
19 |
Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor. |
Universit£ |
| 22148859 |
190 |
Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A2B adenosine receptor antagonists. |
University of Ferrara |
| 22204739 |
136 |
Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists. |
Universit£ |
| 21214204 |
100 |
Synthesis and Biological Evaluation of a New Series of 1,2,4-Triazolo[1,5-a]-1,3,5-triazines as Human A(2A) Adenosine Receptor Antagonists with Improved Water Solubility. |
Universita Di Trieste |
| 21908194 |
88 |
Does the combination of optimal substitutions at the C²-, N¿?¿- and N¿?¿-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A3 adenosine receptors? |
National University of Singapore |
| 21675777 |
139 |
New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists. |
Universit£ |
| 21388809 |
76 |
Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity. |
Roche Research Center |
| 24900298 |
100 |
Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist |
TBA |
| 21186795 |
142 |
Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists. |
University of Santiago De Compostela |
| 21055932 |
137 |
Discovery of novel quinolinone adenosine A2B antagonists. |
Ligand Pharmaceuticals |
| 20937560 |
54 |
Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands. |
Dipartimento Di Scienze Farmaceutiche |
| 20728355 |
47 |
Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists. |
Bayer Schering Pharma |
| 20537438 |
101 |
Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. |
East China University of Science and Technology |
| 20307065 |
122 |
The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition. |
National University of Singapore |
| 20304654 |
79 |
Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process. |
National University of Singapore |
| 20138516 |
29 |
Discovery of potent and selective bicyclic A(2B) adenosine receptor antagonists via bioisosteric amide replacement. |
RhôNe-Poulenc Rorer |
| 20137946 |
81 |
Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists. |
RhôNe-Poulenc Rorer |
| 19733067 |
84 |
Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor. |
Vernalis (R&D) |
| 20031406 |
85 |
Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists. |
Novartis Institutes For Biomedical Research |
| 20202853 |
12 |
Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors. |
Universidad De M£Laga |
| 19743865 |
22 |
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition. |
Universit£ |
| 19501513 |
474 |
Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites. |
Universit£ |
| 19362836 |
83 |
Antagonists of the human A(2A) receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides. |
Vernalis (R+D) |
| 19398343 |
48 |
1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships. |
Universidade De Santiago De Compostela |
| 19317449 |
76 |
N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice. |
University of Camerino |
| 19140664 |
82 |
N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy. |
Neurocrine Biosciences |
| 19072055 |
224 |
Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines. |
Vernalis R&D |
| 19006671 |
136 |
Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists. |
Università |
| 18938084 |
78 |
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships. |
Università |
| 18226896 |
129 |
Selective, high affinity A(2B) adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines. |
Cv Therapeutics |
| 18189346 |
21 |
Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy. |
Neurocrine Biosciences |
| 17827019 |
86 |
Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: structure-activity relationships as adenosine A(1) and A(2A) receptor ligands. |
Jagiellonian University Medical College |
| 17689079 |
36 |
Dual acting antioxidant A1 adenosine receptor agonists. |
Monash University (Parkville Campus) |
| 17469811 |
45 |
Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist. |
Almirall |
| 17300165 |
39 |
2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. |
Leiden/Amsterdam Center For Drug Research |
| 17236762 |
23 |
Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines. |
Schering-Plough Research Institute |
| 17125265 |
49 |
Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists. |
Biogen Idec |
| 17125264 |
60 |
Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists. |
Biogen Idec |
| 17045477 |
136 |
N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists. |
Cv Therapeutics |
| 16821798 |
62 |
A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists. |
University of Bonn |
| 16821770 |
78 |
Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. |
Università |
| 16789747 |
71 |
4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies. |
Università |
| 16759111 |
149 |
Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists. |
Cv Therapeutics |
| 16697192 |
59 |
New pyrrolopyrimidin-6-yl benzenesulfonamides: potent A2B adenosine receptor antagonists. |
RhôNe-Poulenc Rorer |
| 16289820 |
14 |
Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety. |
National Institute of Diabetes and Digestive and Kidney Diseases |
| 16275090 |
136 |
Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists. |
Cv Therapeutics |
| 16250640 |
7 |
Molecular modeling and molecular dynamics simulation of the human A2B adenosine receptor. The study of the possible binding modes of the A2B receptor antagonists. |
M.V. Lomonosov Moscow State University |
| 16033279 |
47 |
New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. |
Università |
| 16000006 |
59 |
New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists. |
Università |
| 15664822 |
101 |
The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma. |
Cv Therapeutics |
| 15294001 |
88 |
Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
Biogen Idec |
| 15203160 |
124 |
Structure-activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma. |
Otsuka Pharmaceutical Factory |
| 15177485 |
2 |
A mild, efficient and alpha-selective glycosidation by using potassium dodecatungstocobaltate trihydrate as catalyst. |
University of Isfahan |
| 14761205 |
56 |
Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. |
University of Bonn |
| 13678407 |
57 |
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation. |
Università |
| 12166943 |
81 |
1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands. |
Nutrition Research Institute |
| 12166930 |
21 |
Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist. |
TBA |
| 12014951 |
139 |
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. |
National Institute of Diabetes & Digestive & Kidney Diseases |
| 11906291 |
129 |
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. |
University of Bonn |
| 11831890 |
278 |
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists. |
Università |
| 11754583 |
112 |
7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility. |
Università |
| 32241719 |
68 |
New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A |
Universit£ |
| 32165041 |
52 |
Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A |
Universit£ |
| 11495585 |
16 |
Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies. |
Università |
| 32573250 |
63 |
Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A |
Uppsala University |
| 11170626 |
55 |
2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor. |
Eisai |
| 11123985 |
176 |
Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen. |
Università |
| 11087559 |
7 |
Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography. |
University of Milano-Bicocca |
| 30808606 |
240 |
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies. |
Jagiellonian University Medical College |
| 27658798 |
376 |
8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors. |
University of Bonn |
| 30576906 |
92 |
Novel non-xanthine antagonist of the A |
Bayer Pharmaceuticals |
| 10737749 |
182 |
Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. |
National Institute of Diabetes |
| 31557025 |
100 |
Trifluorinated Pyrimidine-Based A |
Uppsala University |
| 10669571 |
24 |
Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists. |
University of WüRzburg |
| 31306001 |
117 |
Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity. |
Universit£ |
| 31280999 |
29 |
2-Aryladenine derivatives as a potent scaffold for A |
Universidade Do Minho |
| 31738058 |
154 |
Structure-Based Optimization of Coumarin hA |
University of Porto |
| 30605331 |
236 |
Design and in Vivo Characterization of A |
Medical College of Wisconsin |
| 30835463 |
202 |
A |
Rheinische Friedrich-Wilhelms-Universitat Bonn |
| 9667972 |
119 |
Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes. |
National Institute of Diabetes |
| 30638876 |
108 |
Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity. |
Universit£ |
| 31453698 |
97 |
Antioxidant-Conjugated 1,2,4-Triazolo[4,3- |
Universit£ |
| 24556147 |
52 |
Novel 8-(p-substituted-phenyl/benzyl)xanthines with selectivity for the A2A adenosine receptor possess bronchospasmolytic activity. |
Panjab University |
| 24518296 |
119 |
Discovery of simplified Nē-substituted pyrazolo[3,4-d]pyrimidine derivatives as novel adenosine receptor antagonists: efficient synthetic approaches, biological evaluations and molecular docking studies. |
National University of Singapore |
| 24139167 |
419 |
1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases. |
University of Bonn |
| 24900602 |
32 |
Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists. |
University of Santiago De Compostela |
| 24189496 |
67 |
8-(2-Furyl)adenine derivatives as A?A adenosine receptor ligands. |
University of Camerino |
| 23685887 |
80 |
New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides. |
B.V. Patel Pharmaceutical Education and Research Development |
| 23631427 |
212 |
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones. |
University of Bonn |
| 18249548 |
62 |
Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines. |
University of Santiago De Compostela |
| 30144700 |
176 |
[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A |
Universit£ |
| 29525433 |
41 |
The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A |
Universit£ |
| 28835798 |
68 |
Discovery of Potent and Selective A |
Advinus Therapeutics |
| 29681156 |
71 |
Fluorescent-Labeled Selective Adenosine A |
University of Bonn |
| 29909340 |
90 |
Structure-activity relationship studies and pharmacological characterization of N |
Universit£ |
| 29614417 |
110 |
New potent and selective A |
University of Camerino |
| 28528302 |
15 |
Nanomolar anti-sickling compounds identified by ligand-based pharmacophore approach. |
Universidade Estadual De Feira De Santana |
| 29880250 |
84 |
Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A |
Universit£ |
| 29792714 |
32 |
Docking Screens for Dual Inhibitors of Disparate Drug Targets for Parkinson's Disease. |
Uppsala University |
| 28447789 |
134 |
Exploring the Role of N |
University of Camerino |
| 28368607 |
26 |
Enantiospecific Recognition at the A |
Uppsala University |
| 29446948 |
82 |
A Structure-Activity Relationship Study of Bitopic N |
Monash University |
| 28792759 |
22 |
Effect of Nitrogen Atom Substitution in A |
Uppsala University |
| 29257884 |
75 |
Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A |
University of Camerino |
| 28415011 |
54 |
Design and synthesis of novel xanthine derivatives as potent and selective A |
Advinus Therapeutics |
| 28949521 |
88 |
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor. |
Abbvie |
| 26440714 |
28 |
Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives. |
Quaid-I-Azam University |
| 12110997 |
380 |
In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs. |
WestfÄLische Wilhelms-UniversitÄ |
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