51 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
26463133	22	Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide.	Institute Of Advanced Chemistry Of Catalonia (Iqac-Csic)
26241877	7	Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route.	Pharmaleads
24927250	18	New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment.	Pharmaleads
24767848	2	Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.	University Of Siena
24735644	19	Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-ß hydrolysis.	University Of Lille
18078750	76	Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.	Glaxosmithkline
	20	Dual metalloprotease inhibitors. III. utilization of bicyclic and monocyclic diazepinone based mercaptoacetyls	TBA
	26	Dual metalloprotease inhibitors. II. Effect of substitution and stereochemistry on benzazepinone based mercaptoacetyls	TBA
	30	Dual metalloprotease inhibitors. I. constrained peptidomimetics of mercaptoacyl dipeptides	TBA
21381769	56	Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.	Universite£
22861813	42	Novelß-amino acid derivatives as inhibitors of cathepsin A.	Sanofi-Aventis Deutschland
21780776	40	Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry.	Wroclaw University Of Technology
24900367	16	Proposed Bioactive Conformations of Opiorphin, an Endogenous Dual APN/NEP Inhibitor.	TBA
22224710	44	Structure-activity relationship study of opiorphin, a human dual ectopeptidase inhibitor with antinociceptive properties.	Institute Of Advanced Chemistry Of Catalonia (Iqac-Csic)
18160283	26	Targeting ACE and ECE with dual acting inhibitors.	Universit£
16220969	219	Designed multiple ligands. An emerging drug discovery paradigm.	Organon Laboratories
15658862	30	Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.	University Institute Of Pathology
12852763	20	Computer-aided selection of potential antihypertensive compounds with dual mechanism of action.	Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences
11585456	8	Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.	University Of Paris
9554884	72	Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme.	Novartis Pharmaceuticals
1348542	23	Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.	University Of Paris
	29	Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11	TBA
	15	Synthesis and evaluation of 2-(biphenylmethyl)glutaric acid amide derivatives as neutral endopeptidase inhibitors.	TBA
	65	Solid phase synthesis of phosphinic acid endothelin converting enzyme inhibitors	TBA
	66	Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme by N-phosphonomethyl and N-carboxyalkyl dipeptides	TBA
21937235	7	Structure-based design of dipeptide derivatives for the human neutral endopeptidase.	Kao
21515054	25	Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors.	Pfizer
19899765	69	Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.	Cea
	27	Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by tricyclic benzazepinone thiols	TBA
	8	Studies on the structural feature of S'1 subsite of neprilysin (EC.3.4.24.11): Stereochemical requirement for the enzyme-inhibitor docking process	TBA
	3	Non-peptidic inhibitors of neutral endopeptidase 24.11 2. Design and pharmacology of orally active phosphonate prodrugs	TBA
	2	Synthesis of 6-amino-5-oxo-7-phenyl-1,4-oxazepines as conformationally constrained gauche (−) dipeptide mimetics	TBA
18790648	317	Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.	University Of Athens
18507370	7	Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2.	Mount Sinai School Of Medicine
18243695	44	Thiol-based angiotensin-converting enzyme 2 inhibitors: P1' modifications for the exploration of the S1' subsite.	Glaxosmithkline
17070062	16	Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.	Pfizer
16821800	96	Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides.	Pfizer
11551755	18	Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.	British Biotech Pharmaceuticals
11384231	26	2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors.	F. Hoffmann-La Roche
9046341	44	Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.	Ciba-Geigy
9046340	23	Ortho-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.	Novartis Pharmaceuticals
8360886	4	A mechanism-based inactivation study of neutral endopeptidase 24.11.	Salk Biotechnology/Industrial Associates
8164250	54	New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension.	University Of Paris
28442252	62	Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.	Ranbaxy Laboratories
23339426	46	In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II.	Sakarya University
16458511	44	Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.	Bristol-Myers Squibb
17958342	12	The First Biologically Active Synthetic Analogues of FK228, the Depsipeptide Histone Deacetylase Inhibitor.	University Of Southampton
9514878	7	Discovery of nonsteroidal androgens.	University Of Tennessee At Memphis